Abstract: Objective To investigate the effect of failure model and effect analysis (FMEA) combined with PDCA management tool in 1-h antibiotic use in patients with septic shock. 
Methods In total, 177 patients with septic shock and 32 medical staff were selected as research subjects in the Second Hospital of Hebei Medical University. The medical staff were grouped according to different time periods, with the same medical staff in each group. A total of 87 patients with septic shock and 32 medical staff from January 2022 to June 2022 were selected as control group. A total of 90 patients with septic shock and 32 medical staff from July 2022 to December 2022 were selected as the observation group. The control group was given conventional management, while the observation group was given FMEA combined with PDCA. The general data, risk priority number (RPN) value, compliance rate of 1-h antibiotic use, 28-day mortality rate and cooperation satisfaction of medical staff were compared between the two groups, and the factors affecting the compliance rate of 1-h antibiotic use were analyzed. 
Results There was no significant difference in general information and 28-day mortality between the two groups (P＞0.05). The compliance rate of 1-h antibioticuse and satisfaction degree of medical cooperation of septic shock patients in the observation group were significantly higher than those in the control group, and the RPN values of the first 5 failure modes were significantly lower than those in the control group, with statistical significance (P＜0.05). The results of multivariate analysis showed that the underlying disease (OR=0.585, 95%CI: 0.405-0.845, P＜0.05), antibiotic use grade (OR=0.272, 95%CI: 0.134-0.551, P＜0.05) and family education level (OR=2.484, 95%CI: 1.100-5.611, P＜0.05) were independent risk factors affecting the compliance rate of 1-h antibiotic use. 
Conclusion FMEA combined with PDCA management tools can standardize the process of 1-h antibiotic use in patients with septic shock, improve the compliance rate of 1-h antibiotic use, and strengthen medical cooperation. 

Key words: shock, failure mode and effect analysis, PDCA management tool, anti-bacterial agents