Abstract: Objective The model eyes were implanted with four kinds of intraocular lens (IOL) with different spherical aberration, including spherical IOL, 0 μm aspheric IOL, -0.1 μm aspheric IOL, -0.26 μm aspheric IOL.The 10% better and 10% worse Modulation transfer function (MTF) values of each IOL at 3 mm, 4 mm and 5 mm pupil diameters were compared using Monte Carlo analysis, and the imaging quality and anti-decentration performance were compared. 
Methods For experimental study, four kinds of IOL with different spherical aberration were inserted into the model eye under the condition of pupil diameter of 3 mm, 4 mm and 5 mm, respectively. In the computer optical simulation system, the Monte Carlo analysis method was used to design four kinds of IOL with random 0-0.5 mm decentration, and 1 000 random simulations were performed respectively. The experimental studies with the 10% better and 10% worse image quality of the four IOL were compared. 
Results In the case of random decentration, under the 3 mm pupil diameter, the MTF values of -0.1 μm aspherical IOL, -0.26 μm aspherical IOL and 0 μm aspherical IOL were higher than spherical IOL at the best 10%, and the MTF value of -0.1 μm aspherical IOL was higher than -0.26 μm aspherical IOL and spherical IOL at the worst 10%. Under the 4 mm pupil diameter, the MTF values of -0.1 μm aspherical IOL and -0.26 μm aspherical IOL 10% were higher than -0 μm aspherical IOL and spherical IOL at the best 10%, and the MTF values of -0.1 μm aspherical IOL were higher than those of -0.26 μm aspherical IOL and spherical IOL at the worst 10%. Under the 5 mm pupil diameter, the MTF value of -0.1 μm aspherical IOL was higher than 0 μm aspherical IOL and spherical IOL at the best 10%, and the MTF value of -0.1 μm aspherical IOL was higher than that of the other three IOL at the worst 10%. 
Conclusion -0.1 μm aspherical IOL has good tolerance to decentration and high stability of image quality. 

Key words: cataract, lenses, artificial, Monte Carlo analysis