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    25 May 2016, Volume 37 Issue 5
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    Acetylbritannilactone exerts the neuroprotective effect on ischemic cerebral tissues by inhibiting the inflammatory responses
    WENYa,DONGLi-peng,ZHAOJing-ru,ZHUChun-hua
    2016, 37(5):  497-500,505.  doi:10.3969/j.issn.10073205.2016.05.001
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    [
    Abstract ] Objective Thisstudyistoexploretheprotectiveroleand mechanism of
    Acetylbritannilactone ( ABL ) oninflammatoryresponsesinducedbyfocalcerebralischemiain
    mice.Methods MaleCD1 miceweresubjectedtopermanentmiddlecerebralarteryocclusion
    ( MCAO ) .Themicewererandomlydividedintosham-operatedgroup , MCAOgroup , ABL-L
    group ( 10mg
    /
    kg
    ) andABL-Hgroup (
    30mg
    /
    kg
    ) .ABLwasinjectedintraperitoneally30minutes
    priortoMCAOoperation.Micewereanesthetizedandsacrificedat24hafterstroke.Western
    blottingandRT-PCRwereusedtoexaminetheexpressionoftumornecrosisfactor-α ( TNF-α ),
    interleukin-1 β ( IL-1 β ), Toll-likereceptor4 ( TLR4 ), tumornecrosisreceptorassociatedfactor6
    ( TRAF6 ) andnuclearfactor-kappaB ( NF-κB ) .Andtheneurologicaldeficitscores , brainwater
    contentandinfarctvolumewereexplored.Results Comparedtoshamgroup , theexpressionsof
    TNF-α , IL-1 β , TLR-4 , TRAF6andNF-κBweresignificantlyincreasedin MCAOgroup ( P <
    0.05 ) .ABLtreatmentmarkedlydown-regulatedexpressionsofTNF-α , IL-1 β , TLR4 , TRAF6 ,andNF-κB ( P <0.05 ) .Theneurologicaldeficitscores , infarctvolumeandbrainwatercontent
    werealleviatedcomparedto MCAOgroup ( P <0.05 ) .Conclusion ABLtreatmenteffectively
    ameliorates neurological defect , brain edema and brain infarct volume.ABL decreases
    inflammatory responses by suppressing the expression of the proinflammatory signaling
    moleculesTLR4 , TRAF6
    Effects of combination of Butylphthalide and edaravone on mental status and cognitive function in delayded encephalopathy after acute carbon monoxide poisoning patients
    FANG Jian-fei1， WANG Fang2， XU Jie1， LI Wei1， LU Yan1
    2016, 37(5):  501-505.  doi:10.3969/j.issn.10073205.2016.05.002
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    [
    Abstract ] Objective Toinvestigatetheeffectsofcombination ofButylphthalideand
    edaravoneonmentalstatusandcognitivefunctionindelayedencephalopathyafteractuecarbon
    monoxidepoisoning ( DEACMP ) patients.Methods Atotalof100casesDEACMPpatientswere
    randomlydividedintocontrolgroupandobservationgroup , with50casesineachgroup.The
    controlgroupofpatientswereappliedconventionaltreatment , theobservationgroupweretreated
    withButylphthalideandedaravoneonthebasisofconventionaltreatment.Theefficiencyoftwo
    groupswereobservedafter3treatmentcourses.Beforetreatmentandintreatmentcourse1 , 2 ,
    3 , the patients were evaluated with simple-mental assessment scale ( mini-mental state
    examination , MMSE ) .Beforeandaftertreatment , theefficiencywasevaluatedwithNational
    InstitutesofHealthStrokeScale ( NIHSS ), Barthelindex ( BI ) and HasegawaDementiaScale
    ( HDS ) .Results Theclinicaleffectofobservationgroupwassignificantlybetterthanthatof
    controlgroup (χ
    2 =5.741 ,
    P <0.05 ); MMSEscoreincontrolgroupandinobservationgroupaftertreatment were higherthanthosein groups beforetreatment.Withtheprogressof
    treatment , MMSEscorewasincreased.TheMMSEscoreinobservationgroupwashigherthan
    thoseincontrolgroupateachtimepoint.Thedifferencewasstatisticallysignificantbetween
    groupsanddifferenttime , alsoatdifferenttimepointsinteraction ( P <0.05 ) .TheNIHSSscore
    oftheobservationgroupwaslowerthanthoseincontrolgroupateachtimepoint.TheNIHSS
    scorewassignificantlylowerthanthoseingroupsbeforetreatment , BIscoresandHDSscores
    wassignificantlyincreasedbeforetreatment.NIHSSscoreinobservationgroupwaslowerthan
    thoseinthecontrolgroup , BIscoreandHDSscoreswerehigherthanthoseinthecontrolgroup
    (
    P <0.05 ) .Conclusion ApplicationofButylphthalideandedaravoneinthetreatmentofdelayed
    encephalopathyafteracutecarbonmonoxidepoisoningcansignificantlyimprovementalstateand
    cognitivedysfunction , alsocanimprovethecognitiveabilityanddailylifeability.Thetreatment
    wassafeandeffective , andworthyofpopularizationandapplicationinclinic.
    EffectsofD-galactoseoncognitivequalityandexpressionofGABAR1andNMDAR2BinhippocampusinSDrats
    LU Lanhong1, LI Xiuqing2, LIU Yuanyuan1, SUI Yuelin1*, LIU Jianhui1, LU Ning3
    2016, 37(5):  506-509.  doi:10.3969/j.issn.10073205.2016.05.003
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    [
    Abstract ] Objective ToexplortheeffectsofD-galactoseonthecognitivequalitydecline
    andtheneuronalplasticityintheprocessofagingbyobservingthechangesoflearningand
    memoryqualityandtheexpressionofgamma-aminobutyricacidreceptor1 ( GABAR1 ) andN-
    methyl-D-aspartatereceptor2B ( NMDAR2B ) inrats.Methods MaleSDratswererandomly
    dividedintoexperimentalgroup ( 10 ) andcontrolgroup ( 20 ) .D-galactose ( 15mg ·
    kg
    -1 · d -1 )
    wassubcutaneouslyinjected for 10 weeksin experimental group and the same dose of
    physiologicalsalinewasgiventocontrolgroup.Morriswater mazetestwasperformedafter
    modelprepared.ThenthebraintissuewascollectedandthemRNAtranscriptionandprotein
    expression of GABAR1 and NMDAR2B were detected by in situ hybridization and
    immunohistochemistrymethods.Results Thelatencywassignificantlylongerandthefrequencyofpassingthroughthetargetwassignificantlylessinexperimentalgroupthanthoseinthe
    controlgroup ( P <0.05 ) .GABAR1andNMDAR2BwerepositivelyexpressedatthemRNAand
    proteinlevelineachgroup.Theproteinexpressionand mRNAtranscriptionofNMDAR2Bin
    experimentalgroupwereweakerthanthoseinthecontrolgroup.Buttheproteinexpressionand
    mRNAtranscriptionofGABAR1werehigherinexperimentgroupthanincontrolgroup , the
    differencewasstatisticallysignificant ( P <0.05 ) .Conclusion Thelearningandmemoryquality
    declinewererelatedtotheexpressionchangeofneurotransmitterreceptorssuchasNMDAR2B
    andGABAR1inhippocampusinthebrainagingprocessofSDrats.
    SUDOSCAN technology to screen kidney disease in patients with type 2 diabetes
    HUANG Xue1, ZHAO De-ming2, SHI Lin-tao2, SHEN Bai-yu1, YANG Yueying2, LIU Yan-jun2*
    2016, 37(5):  510-515.  doi:10.3969/j.issn.10073205.2016.05.004
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    [
    Abstract ] Objective ToexplorethefeasibilityandaccuracyofSUDOSCANinscreening
    kidneydiseaseinpatientswithtype2diabetesmellitus ( T2DM ) .Methods Twohundredand
    ninety-sevenpatientswithT2DM wererecruitedinourstudy.Thepatientsweredividedintothe
    normalkidneyfunctiongroup ( controlgroup ) anddiabetickidneydisease ( DKD ) groupaccording
    toestimatedglomerularfiltrationrate ( eGFR ) andurinaryalbumintocreatinineratio ( UACR )Results Serum creatinine ( SCr ), Bloodureanitrogen ( BUN ), UACRin DKD group were
    significantlyhigherthancontrolgroupandeGFRwassignificantlylowerthancontrolgroup ( P <
    0.05 ) .Therewerenostatisticaldifferencesintotalcholesterol ( TC ), triglyceride ( TG ), low-
    densitylipoprotein cholesterol ( LDL-C ) and high-densitylipoprotein cholesterol ( HDL-C )
    betweenthetwogroups ( P >0.05 ) .HESC , FESCandSUDOSCAN-MDRDinDKDgroupwere
    significantlylowerthancontrolgroup ( P <0.05 ) .HESC wasnegativelycorrelatedwithage ,
    diseasedurationand HbA 1 c , butwaspositivelycorrelatedwitheGFR ( P <0.05 ) .FESC was
    negativelycorrelatedwithage , diseaseduration , systolicbloodpressure ( SBP ) andHbA 1 c , but
    waspositivelycorrelatedwitheGFR ( P <0.05 ) .SUDOSCAN-MDRD wasnegativelycorrelated
    withage , diseaseduration , SBPandBUN , butwaspositivelycorrelatedwitheGFR ( P <0.05 ) .
    PredictingkidneydiseasewithSUDOSCAN-MDRD wasbetterthanotherindicators.Thebest
    cut-offvalueofSUDOSCAN-MDRD was57.50uSi.TheareaunderthecurveforDKD was
    67.7%.Thesensitivitywas60.0% , thespecificitywas75.0% , accuracywas68.7% , positive
    predictivevaluewas63.6%andnegativepredictivevaluewas72.1%.Conclusion SUDOSCAN
    indexeswerecorrelatedwithkidneydamageandmaybeusedforearlyriskscreeningforDKD
    amongT2DMpatients
    Clinical observations of bifidobacterium tetravaccine tablets(live) in treatment of thirtytwo cases of diabetic enteropathy
    ZHANG Xiao-juan, ZHANG Jie, LOU Ping-ping, SONG Qing-fang*, WANG Zhan-jian, LIU Kuan-zhi
    2016, 37(5):  516-519.  doi:10.3969/j.issn.10073205.2016.05.005
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    [ Abstract ] Objective Toexploretheclinicaleffectsandsideeffectsofbifidobacterium
    tetravaccinetablets ( live ) inthetreatmentofdiabeticenteropathy.Methods Accordingtothe
    clinicalsymptoms , thirty-twopatientswithdiabeticenteropathyweredividedintotwogroups :
    astrictiongroup ( n =19 ) anddiarrhoeagroup (
    n =13 ) .Exceptroutingtherapy , allofthepatients
    weregivenbifidobacteriumtetravaccinetablets ( live ) .After10daystreatment , thenumberof
    cacation , cacationtime , stoolcharacteristics , cacationwithsimultaneousphenomenonandother
    parameterswerecompared.Results Aftertreatment , alloftheindicesofcacationinastriction
    groupanddiarrhoeagroupwereimprovedascomparedwithpre-treatment ( P <0.05 ) .Thetotal
    efficienciesintheastriction group andinthe diarrhoea group were84.21% and 100% ,
    respectively.Conclusion Theclinicaleffectofbifidobacteriumtetravaccinetablets ( live ) onthe
    diabeticenteropathyisaffirmedwithhighefficiencyandsafety.
    The correlated analysis of serum magnesium levels with type 2 diabetes mellitus complicated with acute cerebral infarction
    XU Jin-xiu，GUO Ning-ning，ZHANG Yun-na，WANG Lin-xia
    2016, 37(5):  520-522,527.  doi:10.3969/j.issn.10073205.2016.05.006
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    [ Abstract ] Objective This study aimsto evaluatethe relationship between serum
    magnesiumlevelsandtype2diabetesmellituscomplicatedwithacutecerebralinfarction , andto
    providesreferenceforthepreventionandtreatmentofdiabeticcomplications.Methods In
    collected81casesfromJanuary2013toDecember2014atthecentralhospitalofCangzhou , type2
    diabetesmellituscomplicated withacutecerebralinfarction ( n =43 ) werechosenasdiabetes
    mellitusandcerebralinfarctim ( DACI ) group , patientswithT2DMandwithoutacuteorchronic
    complicationsinducedbyT2DM ( n =38 ) werechosenasT2DM group , 40healthyindividuals
    wereregardedasnormalcontrolgroup.Theserum magnesium levelsforallpatients were
    detected , thelevelsofbloodpressure ( BP ), fastingbloodglucose ( FBG ), hemoglobin A 1 c
    ( HbA 1 c ), triglyceride ( TG ), totalcholesterol ( TC ), low-densitylipoproteincholesterol (
    LDL-C ),
    high-densitylipoproteincholesterol ( HDL-C ) andBMIweremeasuredaswell.Results Compared
    withcontrolgroup , thelevelofserum magnesiuminDACIgroupandT2DM wereobviously
    decreased ( all P <0.05 ) andthelevelinT2DMgroupswaslowerthanthatinDACIgroup ( P <
    0.05 ) .CorrelatedanalysisofeveryfactorinDACIgroupshowedthattheserum magnesiumlevel wasnegativerelatedwithBP , FPG , HbA 1 c , TC , TG , LDL-C ( all P <0.05 ) andnotrelatedwith
    BMIandHDL-C ( all P >0.05 ) .MultivariateLogisticregressionanalysisrevealedthattheserum
    magnesiumlevels , BP , FBG , HbA 1 careriskfactorsfordiabetespatientswithacutecerebral
    infarction ( P <0.05 ) .Conclusion Hypomagnesemiaisanimportantriskfactorfor T2DM
    patientswithacuteischemiccerebrovasculardisease.
    Effects of Helium-Oxygen Mechanical Ventilationin in patients with acute exacerbation of chronic obstructive pulmonary disease
    ZHU Shuai-jun1， CHEN Dong-mei1， HE Xin-min2， WONG Qin-yong1*
    2016, 37(5):  523-527.  doi:10.3969/j.issn.10073205.2016.05.007
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    [
    Abstract ] Objective Toinvestigatetheeffectofhelium-oxygenmechanicalventilationon
    peakairwaypressure ( Ppeak ), partialpressureofcarbondioxide ( PaCO 2 ), partialpressureof
    oxygen ( PaO 2 ), Interleukin8 ( IL-8 ) andtumornecrosisfactorα ( TNF-α ) inpatientswithacute
    exacerbationofchronicobstructivepulmonarydisease ( AECOPD ) .Methods Sixtycasesof
    mechanicalventilationwereselectedandrandomlydividedintotheexperimentalgroupandthe
    controlgroup , with30casesineachgroup.Allpatients weretreated with modifiedclosed
    ventilator.Experimentalgroup wastreated with helium-oxygen mechanicalventilation ( 60%
    helium vs 40%oxygen ) .Controlgroupwastreatedwithnitrogen-oxygenmechanicalventilation
    (
    60% nitrogen vs 40% oxygen ), ThechangesofPpeak , PaO 2 , PaCO 2 wereobservedbefore treatment , 30min , 90min , 120minaftertreatment.Enzymelinkedimmunosorbentassaywere
    usedtodetectserumconcentrationsofIL-8andTNF-αatfourtimepointsin2groupsofpatients.
    Results ThePpeakandPaCO 2 inexperimentalgroupweredecreasedsignificantly30minafter
    treatmentandthenremainedstability.Butthecontrolgroupdidnotimprovedsignificantly.The
    PaO 2 inexperimentalgroupwasincreasedsignificantly30minaftertreatmentandthenremained
    stability.Butthe controlgroup did notimproved significantly.TheIL-8 and TNF-αin
    experimentalgroupdecreasedsignificantly120minaftertreatment , whilethecontrolgroupdid
    notimprovedsignificantly.Conclusion Helium-oxygen mechanicalventilationcansignificantly
    reduceAECOPD patientsairway pressure , improveoxygenationandreducecarbon dioxide
    retention.Whenthetreatmentreachesacertaintime , theheliumoxygenmechanicalventilation
    canreduceconcentrationsofIL-8andTNF-α , whichhasacertainregulatingeffectonchronic
    airwayinflammation.Atthesametime , Theimprovedventilatorcanbeachievedusingthe
    heliumcycle , whichgreatlysavesthecostoftreatment.
    Evaluation of predictive nursing care in the prevention of unplanned extubation in the ICU
    BI Juan1， TANG Li-mei2， WANG Juan3
    2016, 37(5):  528-530,536.  doi:10.3969/j.issn.10073205.2016.05.008
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    [
    Abstract ] Objective Toexploretheclinicalpracticeeffectofpredictivenursingprocedure
    onpreventionoftheneurologyunscheduledtubedrawing.Methods Basedonthemethodof
    conveniencesampling , 200ICUpatientsfromnerveinternalmedicinewererandomlydividedinto
    controlgroupandinterventiongroupwithrandomnunbertable , eachof100.Interventiongroup
    patientswereappliedpredictiveunscheduledextubationnursingprocess.Controlgrouppatients
    weregivenroutinehealthcare.Thenuscheduleddecannulationrateandsatisfactionofthe
    patientswereassessed.Results Theunscheduleddecannulationrate was3% and15% in
    observationgroupandinthecontrolgroup , respectively.Thedifferencebetweentwogroupswas
    statisticallysignificant ( P <0.05 ) .Thedifferenceofsatisfactionofthepatientsbetweentwo
    groups wasstatisticallysignificant ( P <0.05 ) .Conclusion Theimplementionofpredictive
    nursingprocedurecanreducetheunscheduleddecannulationrateinneurologyICUandimprove
    satisfactionofpatients.
    Study on the efficiencies of the mobilization， collection and the safety of the transplantation of autologous peripheral blood stem cell for myocardial infarction patients
    LI Qiang1, LIU Yan-chao1, LIU chao2, MENG Zi-li1, WANG Wei3*, LIU Yonghui1
    2016, 37(5):  531-536.  doi:10.3969/j.issn.10073205.2016.05.009
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    [
    Abstract ] Objective Toinvestigatetheefficienciesof mobilization andcollection of
    autologousperipheralbloodstemcell ( APBSC ) formyocardialinfarctionpatients.Andtostudy
    thesafetyandfeasibilityofmyocardialinfarctiontreatmentviatheautologousperipheralblood
    stemcelltransplantation ( APBSCT ) .Methods Forty-sixmyocardialinfarctionpatientswiththe herapyofconventionaldrugweregivenrecombinanthumangranulocytecolonystimulatingfactor
    (
    rhG-CSF ) 450 μ g / d ( ≤65kg ) or600 μ g / d ( >65kg ) bysubcutaneousinjectionatfivedays
    beforecoronaryarterybypassgraft ( CABG ), accordingtopatient'sbodymass , thenwerecarried
    onthe APBSC mobilizationandexpansion.APBSCs werecollected24hbeforeCABG.All
    patientsunderwentCABGwithnon-cardiopulmonaryby-pass , andtheAPBSCswereinjectedvia
    thebridgecoronary vesselsandsub-epicardially.Beforeandafter APBSC mobilizationand
    collection , mononuclearcell ( MNC ) andCD34
    +
    cellfromtheperipheralbloodweretested , and
    thebloodpressure , heartrate , respiratory , whitebloodcell ( WBC ), redbloodcell ( RBC ),
    hemoglobin ( Hb ), hematocrit ( Hct ), platelet ( Plt ) andserum Ca
    2+
    werealsotested.Adverse
    reactionsintheprocessofAPBSC mobilization , collectionandtransplantation wereobserved.
    Results ThenumbersofWBC , MNCandCD34
    +
    cellsinperipheralbloodwereallsignificantly
    increased ( P <0.01 ) after APBSC mobilizationthanthatbefore APBSC mobilization.After
    APBSCcollection , thenumbersofMNCandCD34
    + cellsweresignificantlyincreased (
    P <0.01 ) .
    Nosignificanceexistedinthebloodpressure , heartrate , respiratory , WBC , RBC , Hb , Hctand
    serum Ca
    2+
    ( P >0.05 ) .ThenumberofPlt wassignificantly ( P <0.01 ) decreasedafter
    collection.Adversereactionsoccurredin20casesduring APBSC mobilization , collectionand
    transplantation , includingtheadversereactionof17.4% ( 8 / 46 ) inAPBSCmobilization , 10.9%
    (
    5 / 46 ) inAPBSCcollection , and15.2% ( 7 / 46 ) intransplantation.Conclusion TheMNCand
    CD34
    +
    cellscanbegreatlyincreasedafterAPBSC mobilizationandcollection , indicatingsafty
    andfeasibilityofAPBSCTformyocardialinfarction.
    The treatment strategies on ctitical neurosurgical patients complacatied with severe lung infection
    CHEN Hong-you1， CAO Zuo-wei1， ZHAO Jia-hui2
    2016, 37(5):  537-539,543.  doi:10.3969/j.issn.10073205.2016.05.010
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    [
    Abstract ] Objective Toinvestigatethefeaturesandtreatmentstrategiesofctitical
    neurosurgicalpatientsthatgotseverepulmonaryinfection.Methods Atotalof82casesof
    neurosurgicalpatientscomplicated with severe pulmonaryinfection patientstreatedin our
    departmentfrom2010-2014wereselected.Sedationandmusclerelaxationagentstocooperate
    with mechanicalventilationtocontrolbreathing , combinedempiricalantibiotictherapyand
    pathogenicbacteriatargettherapy , andactivesupporttherapywereused.Results Themortality
    rateof82casesofcriticalneurosurgicalpatientswithseverepulmonaryinfectionwas14. 6% ( 12 /
    82 ) aftertreatment.Conclusion Criticalneurosurgicalpatientswithseverepulmonaryinfection
    couldgeteffectivecontrolwithactiveandeffectivecomprehensivetreatment.

    Expression and significance of miR221 in patients with thyroid diseases
    JI Hong, DI Wang, YAN Li, ZHANG Lin-lei, LI Qing-huai*
    2016, 37(5):  540-543.  doi:10.3969/j.issn.10073205.2016.05.011
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    [
    Abstract ] Objective TostudytheexpressionofmiR-221inbiopsytissueofthyroiddisease
    andperipheralblood.Methods Specimenswereobtainedbyultrasoundguidedcore-needlein51
    casesofpatientsdiagnosedwiththyroidnodules.Peripheralbloodsampleswerecollectedbefore
    operation.QuantitativePCRmethodwasusedtodetecttheexpressionofmiR-221levelsintissue
    andplasma.Results ThedifferenceoftheexpressionofmiR-221inbenignlesionsandnormal
    tissuewasnotstatisticallysignificant ( P >0.05 ) .Inthyroidcancercases , miR-221expression
    levelincanceroustissueweresignificantlyhigherthanthatinnormaltissueadjacenttothyroid
    leisions ( P <0.05 ) .ThereweresignificantdifferencesintheexpressionofmiR-221indifferent
    pathologicalstagesofthyroidcarcinomaandinlymphnodemetastasis ( P <0.05 ) .Thelevelof
    miR-221inperipheralbloodofpatientswiththyroidcancerwassignificantlyhigherthanthatin
    healthycontrolgroupandinbenignthyroiddiseasegroup ( P <0.05 ) .Conclusion Thehigh
    expressionofmiR-221iscloselyrelatedtotheprogressionofthyroidcarcinoma.
    , whichcan
    providenovelideaswithpreoperativediagnosisandindividualizedtreatmentforthyroidcancer.
    Clinical study of sequential end-to-side pancreatojejunostomy in patients with pancreatic and duodenal resection
    BIAN Wei， DU Cheng-xu, LI Dong-rui, LIU San-guang, WANG Wen-bin, LIU Jian-hua
    2016, 37(5):  544-546.  doi:10.3969/j.issn.10073205.2016.05.012
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    [
    Abstract ] Objective Tocomparethepancreaticleakageratesoftwopancreatojejunostomy
    methods applied in pancreatoduodenectomy , which are traditional end-to-end
    pancreatojejunostomy and end-to-side pancreatojejunostomy with external drainage of the
    pancreaticduct.Methods Theclinicaldataof95patientswhowereadmittedinourdepartment
    andhadpancreatoduodenectomywereretrospectivelyanalysed.The95patientsweredividedinto
    2groupsaccordingtothetypesofanastomosis , including65patientsinthetraditionalgroup
    ( end-to-end
    pancreatojejunostomy ) and 30 in the modified group
    ( end-to-side
    pancreatojejunostomywithexternaldrainageofthepancreaticduct ) .Thepancreaticleakagerates
    ofthesetwogroupswerecompared.Results Fourteenoutof95patientshadpancreaticleakage ,
    including13casesintraditionalgroupand1casesinmodifiedgroup.Conclusion Thepancrearic
    leakage rate can be reduced in pancreatoduodenectomy
    by applying
    end-to-side
    pancreatojejunostomywithexternaldrainageofthepancreaticduct
    Analysis of the application effect of detachable patient pants in patients after transurethral resection of prostate
    XU Hui, AN Shu-hui, SHI Lei, CHEN Jun-xiao, HU Ran
    2016, 37(5):  547-549.  doi:10.3969/j.issn.10073205.2016.05.013
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    [
    Abstract ] Objective Toinvestigatetheapplication ofdetachably patientpantsafter
    transurethralresectionofprostate.Methods Twohundredandtenpost-prostatectomypatients
    wererandomlydividedintoexperimentalgroupandcontrolgroup.Eachgroupwasassignedwith
    105patients.Patientsinexperimentalgroup weardetachablepatientpants , andpatientsin
    controlgroupweartraditionalpatientpants.Patientsatisfaction , theincidenceofurinarytract
    infectionandthenurseworkingefficiency , hospitalizationtimeandpostoperativerecoverytime
    wereobservedafterapplication.Results Theurinarytractinfectionsinexperimentalgroupwas
    significantlylowerthanthatinthecontrolgroup ( 21.9% vs 35.2% , P <0.05 ) .Perinealcaretime
    inexperimentalgroupwassignificantlylowerthanthatinthecontrolgroup ( 7. 13±1.48 ) min vs
    (
    7. 82± 1.39 ) min ( P < 0.05 ) .Hospitalization time and postoperative recovery timein
    experimentalgroupwassignificantlyshorterthanthatinthecontrolgroup ( 10. 2±2.3 ) d vs
    (
    12. 1±2.5 ) d ,( 7. 2±2.1 ) d vs ( 8. 4±1.9 ) d ( all P <0.05 ) .Patientsatisfactioninexperimental
    groupwassignificantlyhigherthanthatinthecontrolgroup ( 93.3% vs 79.0% , P <0.05 ) .
    Conclusion Thedetachablepatientpantsachievehighrecognition , whileimprovingpatient
    satisfaction.Furthermore , thedetachablepatientpantssavenursestime , shortenthehospital
    stayandpostoperativerecoverytime , reducechanceforurinarytractinfections.
    Clinical study on the therapeutic scheme and curative effect of retreating postoperative spinal tuberculosis
    YAO Li-ming1, ZHAO Qian2, LIU Feng-sheng1, LI Zhuo1, DONG Zhao-liang1, JIA Chen-guang1*
    2016, 37(5):  550-554.  doi:10.3969/j.issn.10073205.2016.05.014
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    [
    Abstract ] Objective Toinvestigatethetherapeuticschemeandcurativeeffectofretreating
    postoperativespinaltuberculosis.Methods Atotalof35patientswithpostoperativerecurrence
    ofspinaltuberculosis underwentindividualtreatment , which werestudied retrospectively.
    Individualoperation wasperformed : 10cases withdebridementandsinusresection , 5 with
    debridementandinterbodyfusion , 8 withdebridement , interbodyfusionandanteriorinernal
    fixation , 7withdebridement , interbodyfusionanddislodgmentofinternalfixator , 5withone
    stagedebridement , interbodyfusion , dislodgmentofprimaryinternalfixator , combinedanterior
    or posterior internal fixation. All patients were followed regularly , and treated by
    antituberculosischemotherapyfor18~24months.Clinicaleffect , focusheelingandbonefusion
    wereevaluatedatfollow-upperiod.Theoutcomeswereretrospectivelyanalysedbypreoperative
    andpostoperativeVisualAnalogueScale ( VAS ) scoresand Oswestry DisabilityIndex ( ODI )
    scores.Results Thefollow-upperiod wererangedfrom 28to48 months.Allcases were recovered , andtherehadnorecurrence.Allhadgoodhealingofbonegraftafteroperation.After
    admissiontheVASscoreswasdecreasedfrom6. 41±2.56offirstdayafteradmissionto3. 20±
    1.48ataweekafteroperation ( P <0.05 ) .ThereweresignificentimprovementsofODIscores
    from65. 34±25.48preoperativelyto15. 42±7.56atthefinalfollow-up ( P <0.01 ) .Conclusion
    Thecurativeeffectofretreatingpostoperativespinaltuberculosiswasmultifactoriallyeffectedby
    manycomplicatedfactors.Theadequatepreoperativeevaluation , individualantituberculosis
    chemotherapyandoperationaccordingtoprevioustherapeuticschemecouldimprovethepain.
    Thefunctionalongwithqualityoflifewerekeytoimprovingthecurativeeffect.
    The long-term therapeutic effect of two operation methods on early breast cancer patients#br#
    MIAOJiang-yu,GUOBing-xun,ZHANGJing,MAJian-ting
    2016, 37(5):  555-557.  doi:10.3969/j.issn.10073205.2016.05.015
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    [ Abstract ] Objective To analysisthelong-term clinicalresults of modified radical
    mastectomyversuspartialmastectomywithaxillarylymphnodedissectiononphaseⅠ , Ⅱbreast
    cancerpatients.Methods BreastcancerpatientsinphaseⅠ , Ⅱ ( n =100 ) weredividedintotwo
    groups : modifiedradicalmastectomygroup (
    controlgroup , n =50 ) andpartialmastectomywith
    axillarylymphnodedissectiongroup ( observationgroup , n =50 ) .Survivalrate , transferrate ,
    recurrentrate , performancestatusandscoresofsurvivalqualitybetweenthetwogroupswere
    compared.Results Therewerenosignificantdifferencebetweenthetwogroupsintermsof
    survivalrate , transferrateandrecurrentratebetweenthetwogroups ( P >0.05 ) .Thereisan
    increasingtrendintheperformancestatusinthetwogroups , andtheincreasedegreein
    observationgroupsishigherthancontrolgroup.Scoresofqualityoflifeofthe2groupswereall
    decreased.Theobservationgroupwaslowerthanthecontrolgroupandthedescendrangeinthe
    observationgroupissmallerthancontrolgroup.Therewerestatisticallysignificantdifferencesin
    theinteractionofthetwogroupsatthesametimebetweenthetwogroups , thedifference
    betweenthetwogroups , andthedifferencebetweenthetwogroups ( P <0.05 ) .Conclusion
    Breastsectionexcisionandaxillarylymphnodedissectioninthetreatmentofearlybreastcancer
    issuperiortobreastcancermodifiedradicalmastectomy.Itisworthyofclinicalapplication.
    Study on the enzymatic reaction kinetics of epimeric isomers of budesonide in rat liver microsomes by HPLC
    LIU Yan-shuang1, GUO Wei2
    2016, 37(5):  558-561,566.  doi:10.3969/j.issn.10073205.2016.05.016
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    [
    Abstract ] Objective Toidentifythedifferencesoftheenzymaticreactionkineticsoftwo
    epimericisomersofbudesonideinratliver microsomes.Methods Theratliver microsomes
    ( RLM ) wasprepared by ultracentrifugation , andtheconcentration ofepimericisomersof
    budesonideco-incubatedwithRLM weredeterminedbyhighperformanceliquidchromatography.
    Results Themetabolicdifferencesoftwoisomersofbudesonidewereobservedafterbudesonide
    incubatedwithRLM.Themetabolismof22R-budesonidewasfasterthanthatof22S-isomerin
    theearlystageofincubationsoratlowconcentrationofmicrosomalenzymeused.However , with
    theprolongation ofincubationtimeorincreasedconcentration of microsomalenzyme , the
    metabolismof22S-budesonidewasobviouslyfasterthan22R-isomer.ThevaluesforK m andV max
    of22R-budesonidewereabout2timesgreaterthanthoseoftheepimer ( 22S ) .Conclusion The
    higheraffinityfor22R-budesonideandwithasmallvalueofV max , wasthemainreasonforthe
    presentedmetabolicprofileofepimericisomersofbudesonide.
    Evaluation of clinical value of PET/CT and MRI and combination in differential diagnosis of benign and malignant pancreatic lesions
    ZHENG Li-chun1, ZHANG Wen-jun1, LIU Gui-chao1, LI Xiang-chun2, YIN Jun3, ZHANG Xiao-ming1*
    2016, 37(5):  562-566.  doi:10.3969/j.issn.10073205.2016.05.017
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    [
    Abstract ] Objective Toevaluatethediagnosticvalueofpositronemissiontomography /
    computedtomography ( PET / CT ) and magneticresonanceimaging ( MRI ) andcombinationof
    bothmethodsinbenignandmalignantpancreaticlesions.Methods Retrospectiveanalysisofthe
    patientswithpancreaticlesionswhohadexaminedPET / CTandMRI ( timeintervalof2weeksor
    less ) wasusedinthisstudy.Theresultswereconfirmedbypathologyorfollow-upwithclinic
    imaging ( follow-upfor1yearormore
    ), thediagnosticsensitivity , specificity , accuracy , positive
    andnegativepredictivevalue wweregotten bythestatisticsofthetwo methodsandtheir
    combinationinbenignandmalignantpancreaticlesions.Results In67pancreaticlesions , the
    resultsofpathologyorfollow-upwere41malignantand26benign.Thesensitivity , specificity  accuracy , positivepredictivevalueandnegativepredictivevaluewereshownrespectively
    : PET /
    CT was85.37% , 80.77% , 83.58% , 87.50% and77.78% , MRI was80.49% , 76.92% ,
    79.10% , 84.62%and71.43% , PET / CT+MRIwas90.24% , 84.62% , 88.06% , 90.24%and
    84.62%.Therewasnosignificantdifferenceindiagnosticaccuracybetweenthe3methods ( P >
    0.05 ) .Conclusion PET / CTand MRIhashighdiagnosticvalueindifferentiatingbenignand
    malignantlesionsofthepancreas.Ifnecessary , bothofthem canimprovetheaccuracyof
    diagnosisofbenignandmalignantpancreaticdiseases.
    Significance of meglumine diatrizoate gastrointestinal angiography combined with multi-slice computed tomography in diagnosis and treatment of intestinal obstruction
    GAO Lei
    2016, 37(5):  567-570,578.  doi:10.3969/j.issn.10073205.2016.05.018
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    [
    Abstract ] Objective Todiscusstheapplicationofmegluminediatrizoategastrointestinal
    angiographycombinedwithmulti-slicecomputedtomography ( MSCT ) indiagnosisandtreatment
    ofintestinalobstruction.Methods Retrospectiveanalysiswasperformedontheclinicaldataof60
    patientswithintestinalobstruction , where36casesadmittedfrom2008to2012onlyreceived
    abdominalMSCT scan ( controlgroup ) and24casesadmittedfrom 2013to2014received
    combineddiagnosisofmegluminediatrizoategastrointestinalangiographyandMSCT ( meglumine
    diatrizoategroup ) .Comparisonandanalysiswereperformedontheaccuracyofthetwomethods
    indiagnosingandlocatingintestinalobstruction.Results Forthe36casesincontrolgroup , 3
    caseshadtheirsymptomsofintestinalobstructionrelievedaftergastrointestinaldecompression ,
    andtherestof33caseswithunrelievedintestinalobstructionallreceivedsurgicaltreatment ,
    wherethecoincidencerateofpreoperativeimageologicalexaminationforobstructionsiteis
    69.7% ( 23 / 33 ); forthe24casesin megluminediatrizoategroup , aftermegluminediatrizoate
    gastrointestinalangiography , X-raytrackingradiographyoferectandsupinepositionsonA-P
    projectionindicatedthat7caseshadtheirsymptomsofintestinalobstructionrelievedwithin48
    hours ( in5casesthecontrast mediaenteredthecolon within24hours ; 2caseshadtheir symptomsofobstructionrelievedin24~48hours ), whiletherestof17caseswithunrelieved
    intestinalobstructionallreceivedsurgicaltreatmentwherethecoincidencerateofpreoperative
    imageologicalexaminationforobstructionsiteis94.1% ( 16 / 17 ) .Successrateofnon-surgical
    treatmentandcoincidencerateofobstructionsiteinmegluminediatrizoategroupishigherthan
    thatofthecontrolgroup ( P <0.05 ) .Conclusion Meglumine diatrizoate gastrointestinal
    angiographycombinedwithmulti-slicecomputedtomographyisofgreatsignificanceindiagnosis
    andtreatmentofintestinalobstruction
    Effects of different doses of ketamine on rocuronium induced injection pain and cardiovascular responses
    LIFan
    2016, 37(5):  571-574.  doi:10.3969/j.issn.10073205.2016.05.019
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    [ Abstract ] Objective Toinvestigatetheeffectsofdifferentdosesofketamineonrocuronium
    inducedinjectionpainandhemodynamicresponseduringanesthesiainduction.Methods One
    hundredandsixtycasesoftrachealintubationpatientswererandomlydividedintofourgroups :
    normalsaline2 mL ( group A ), injection0.1 mg / kgketamine2 mL ( groupB ), 0.2 mg /
    kg
    ketamine2 mL ( groupC ), 0.3 mg / kgketamine2 mL ( group D ) .Afterpretreatmentwith
    experimentaldrugbydoubleblindedmethods , 10mgofrocuronium wasthenadministered30s
    later.Thepainseveritywasscoredaccordingtothescaleoffourpointchiarella.Hemodynamic
    parameterswerethencollectedatbaselineat0 min , 1 min , 2 minfollowinginjectionofall
    anesthetics , aswellasat0 min , 1 min , 3 minaftertrachealintubation.Results Therewas
    significantdifferenceintheincidenceofinjectionpainbetweenthe4groups ( P <0.01 ) .The
    incidenceofinjectionpainingroupCandgroupDwassignificantlylowerthanthatingroupA
    (
    P <0.05 ) .TheincidenceofinjectionpainingroupDwassignificantlylowerthanthatingroup
    B ( P <0.05 ) .The4groupsofpatientswith MAP , SBP , DBP werefirstdecreasedandthen
    increased.HRshowedagraduallyincreasingtrend.Andwiththeincreaseofthedosageofthe drug , thechangerangewassignificantlydecreased.Thereweresignificantdifferencesinthe
    interactionbetweenthegroups , thetimepointandthetime between groups ( P <0.05 ) .
    Conclusion Pretreatmentwithketaminecanrelievetheinjectionpaininducedbyrocuronium
    dosage-dependently.Withtheincrease ofthe dose , hemodynamics was morestable , side
    reactionswasless.Itisworthyofclinicalapplication.
    Application of quality control circle in PIVAS optimizing prescription-checking
    FEGN Rui, ZHENG Ying, LIU Jiang*, DU Wen-li, GAO Ya-qian, LI Dong
    2016, 37(5):  575-578.  doi:10.3969/j.issn.10073205.2016.05.020
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    [
    Abstract ] Objective Tooptimizeworkflowandensuredrugsafetybyqualitycontrolcircle
    ( QCC ) inpharmacyintravenousadmixtureservices ( PIVAS ) .Methods Toplan , implement ,
    verifyandhandleinaccordancewiththeQCCSteps.Thenumberofweeklyprescriptionsfor
    errorwascomparedbeforeandafterQCCactivity , theachievablerateandprogressiveratewere
    calculated.TheeffectsofQCCactivitywasstandardized , reviewedandimproved.Results The
    prescriptionsforerrorswerereducedfrom23 / weekto9 / week , andtheemployeemotivationand
    responsibilitywereincreased.Conclusion ThedevelopmentofQCCactivityinPIVASfindsand
    solvestheinternalproblem , reducestheprescriptionsforerrors , improvesteamcohesiveforce
    andthepharmacyservicequality.