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    25 April 2016, Volume 37 Issue 4
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    Short-termeffectoflargedosageiodinecontrastonthyroidfunctionand morphologyindiagnosisandtreatmentofcoronaryheartdisease
    WANGYa-ling,LIYong-jun,WANG Mei
    2016, 37(4):  373-376.  doi:10.3969/j.issn.10073205.2016.04.001
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    [
    Abstract ] Objective Toobserveshort-termeffectoflargedosageiodinecontrastonthyroid
    functionandmorphologyindiagnosisandtreatmentofcoronaryheartdisease.Methods Fifty
    patientswith normalthyroidfunction underwentcoronaryangiography.Fifty patients with
    normalthyroidfunction underwentpercutaneouscoronaryintervention .Thebloodfreetri-
    iodothyronine ( FT 3 ), freethyroxine ( FT 4 ), totaltri-iodothyronine ( TT 3 ), totalthyroxine ( TT 4 ),
    thyroid-stimulating hormone ( TSH ), thyroid peroxidase ( TPO ), thyro globulin antibody
    ( TGAB ), thyroidstimulatingantibody ( TSAB ) weremeasuredandthyroid morphologywere
    measuredbyultrasonographybeforeangiographyandtwoweeksafterthetherapy.Results
    ThereweresignificantchangesofTSHandFT 3 comparedwithbeforetherapyaftertwoweeks
    (
    P <0.05 ) .Buttherewasnosignificantchangebetweentwoguoups.Therewerenosignificant
    changesofFT 4 , TT 3 , TT 4 , TPO , TSAB , TGABafterthe2 weekscompared withbefore
    therapy ( P >0.05 ) .Andtherewasnochangebetweentwogroups.Therewasnoobviouschange onthyroidmorphologymeasuredbyultrasonographyafter2weeks.Conclusion Therehasrisk
    ofsubclinicalthyroidfunctionhyperfunctionwithlargedosageiodinecontrastindiagnosisand
    treatmentofcoronary heartdiseaseinthenearfuture.Therehasnoinfluenceonthyroid
    morphologywithlargedosageiodinecontrastindiagnosisandtreatmentofcoronaryheartdisease
    inthenearfuture.
    TheroleofRIPK3overexpressioninregulationofthetranscriptionofmTORanddownstreamgenes
    ZHANG Guo-lu1, CHENG Shi-xiang1, XU Zhong-wei2, YI Tai-long1，TU Yue1*, ZHANG Sai1
    2016, 37(4):  377-381.  doi:10.3969/j.issn.10073205.2016.04.002
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    [
    Abstract ] Objective Theaimofthisstudyistoinvestigatethedownstream pathwayof
    receptor-interactingproteinkinase3 ( RIPK3 ) .Methods SH-SY5Y wasstablytransfectedwith
    pCMV6-RIPK3recombinantplasmidtoup-regulateexpressionofRIPK3 , whilecontrolgroup
    wastransfectedwithemptyvector.RIPK3levelintransfectedSH-SY5Ycellsweredetermined
    usingwesternblot.Cellproliferationactivitywasmeasuredby MTTtodetecttheactivityof exogenousRIPK3.Thedifferentiallytranscriptedgenesbetweentwogroupswereidentifiedby
    RNAseq.Ingenuitypathwayanalysis ( IPA ) revealedagreatroleofRIPK3anditsdownstream
    signalpathwaysandthekeymoleculemammaliantargetofrapamycin ( mTOR ) .Dropletdigital
    PCR ( ddPCR ) analysiswasusedtofurtherconfirmexpressionofmTOR.Results PlasmidDNA
    wasintegratedintothecellgenome.WesternblottingresultssuggestedthatexogenousRIPK3
    wasexpressedinexperimentalgroup.MTTresultsshowedthatexogenousRIPK3couldinhibit
    cellviability.RNAseqandIPAshownthatoverexpressionofRIPK3upregulatedthetranscription
    levelsof mTOR , andaffected downstream genessuch assterol-response binding proteins
    (
    SREBPs ), p70ribosomalS6proteinkinases ( S6K ), eukaryoticinitiationfactor4E-binding
    proteins ( 4E-BPs ) andunc-51-likekinase (
    ULK ) .ddPCRanalysisshowthatthechangeofthe
    expressionlevelofmTORwasthesameasthatofRNAseq.Conclusion RIPK3couldregulate
    transcriptionofmTORsignalcascadeandplayanimportantroleindevelopment , inflammation
    andtumorigenesisofthenervoussystem.
    Bilateral standard large trauma craniotomy combined with mild hypothermia hibernation therapy for acute traumatic brain swelling
    CHEN Hong-you, CAO Zuo-wei
    2016, 37(4):  382-384,389.  doi:10.3969/j.issn.10073205.2016.04.003
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    [
    Abstract ] Objective Toinvestigatetheeffectofbilateralstandardlargetraumacraniotomy
    combinedwithmildhypothermiahibernationtherapyinthetreatmentofacutetraumaticbrain
    swelling.Methods Onehundred-twelvecasesofpatientswithacutetraumaticbrainswelling
    werechosentobeobservedandrecordedtheprognosis.Amongthem , 68casesasexperimental
    groupweretookbilateralstandardlargetraumacraniectomycoupled with mildhypothermia
    therapy , 44casesascontrolgroupweretreatedwithconventionaldecompressivecraniectomyand
    routinetreatment.Results Theclinicalefficacyoftheexperimentalgroup wassignificantly
    betterthanthatofthecontrolgroup , thedifferencewasstatisticallysignificant ( Uc =3.839 , P =
    0.001 ) .Theeffectiverateoftheexperimentalgroupwas ( 67.6% ), significantlyhigherthanthat
    ofthecontrolgroup ( 27.3% ), thedifferencewasstatisticallysignificant
    (
    P <0.01 ) .Conclusion
    Theeffectsofbilateralstandardtraumalargeboneflapdecompressioncombined with mild
    hypothermiahibernationtherapyforacutetraumaticbrainswellingwassignificant , theprognosis
    isbetterthanconventionaltreatment
    Effectsofbutylphthalidecombinedwithedaravoneonblood-brainbarrierpermeability#br# andoccludinexpressionsincortexoffocalcerebralinfarctioninrats
    WANGLi-na1, WANGLi-juan 2,HUZhen-fang 3,LIUShi-yan1,LIU Yong-liang1, WANGPeng 1
    2016, 37(4):  385-388.  doi:10.3969/j.issn.10073205.2016.04.004
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    [
    Abstract ] Objective Toexploretheeffectsofbutylphthalidecombinedwithedaravoneon
    blood-brainbarrierpermeabilityandoccludinexpressionsincortexoffocalcerebralinfarctionin
    rats.Methods Sixtysprague-dawleymaleratswererandomlydividedintofourgroups : control
    group , modelgroup , butylphthalidegroupandbutylphthalidecombinedwithedaravonegroup ,
    with15ratsineachgroup.Themodelwasestablishedbasedontheprincipleofphotochemical
    initiationofthrombosis.At72hafterinjury , evansblueextravsationmethodwasusedtodetect
    theblood-brain barrierpermeability.Immunohistochemistryand western blot wereusedto
    examinethecortexoccludinexpressionaroundtheinfarctionarea.Results Comparedwiththe
    controlgroup , theblood-brainbarrierpermeabilitiesinthemodelgroup
    , butylphthalidegroup
    andthebutylphthalidecombined withedaravonegroup wereincreasedsignificantly.Andthe
    occludinexpressionsaroudtheinfarction wereupregulatedsignificantly.Compared withthe
    modelgroup : evans blueextravsationsin cortexin the butylphthalide group andin the butylphthalidecombined withedaravonegroup weredecreased , andtheoccludinexpressions
    aroudtheinfarctionareawereincreased.Comparedwiththethebutylphthalidegroup : evansblue
    extravsationincortexinthebutylphthalidecombinedwithedaravonegroupwasdecreased , and
    theoccludinexpressionaroudtheinfarction wasincreased.Conclusion Butylphthalidecould
    protectthebolld-brainbarrier , andincreasetheexpressionofoccludin.Theeffectwas more
    obviousbyusingthecombinationofbutylphthalideandedaravone.
    Clinical analysis with 21 cases of primary hyperparathyroidism
    JI Hong1, QI Jin-chun2, XUE Wen-yong2, WANG Dong-bin2, LI Qing-huai1*
    2016, 37(4):  389-391,396.  doi:10.3969/j.issn.10073205.2016.04.005
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    [
    Abstract ] Objective Toinvestigateclinicalmanifestations , diagnosis methodandearly
    detectionmeasuresand misdiagnosisreasonsofprimaryhyperparathyroidism ( PHPT ) andto
    raiseawarenessofparathyroiddisease.Methods Theclinicaldataof21casesofpatientswith
    PHPTwerecollectedandtheirclinicalfeatureswereanalyzed.Results Atotalof21PHPT
    patientswerepathologicallydiagnosedwithparathyroidadenoma.Theirclinicalmanifestations
    includedbonepain , osteoporosis , pathologicfractures , urinarycalculiandsoon.Beforesurgery ,
    elevatedintactparathyroidhormonelevels werefoundin19cases ( 90.1% ), elevatedblood
    calcium werefoundin18cases ( 85.7% ), reducedbloodphosphorus wasfoundin13cases
    (
    61.9% ) andelevatedbloodalkalinephosphatasewerefoundin11cases ( 52.4% ) .Thelesion
    detectionratewas81.0% ( 17 / 21 ) byneckcolorDopplerultrasound.Thelesiondetectionratewas
    53.3% ( 8 / 15 ) byneck CT.Thelesiondetectionrate was100.0% ( 21 / 21 ) byparathyroid
    radionuclideimagingand95.2% ( 20 / 21 ) by neck ultrasoundcombined with bloodcalcium
    examination.Allpatientsunderwentparathyroidresectioninaffectedside.Allthe21cases
    appearedperioralandlimb numbness postoperatively and 5 cases ( 23.9% ) appearedlimb
    convulsion.Conclusion Cliniciansshouldraiseawarenessofparathyroiddiseases.Theuseof neckcolorultrasoundcombined with bloodcalcium examinationhelpsthescreeningofthe
    disease.Surgeryistheonlymeansoftreatingthedisease , andaccuratepositioningpreoperatively
    isconducivetonarrowsurgeryproberangeandtominimizedamagetosurroundingtissues.
    Relationship between high expression of intercellular adhesion molecule-1 and early acute lung injury of rats with severe acute pancreatitis
    LI Xin-jiang, FANG Yan-wei, WEI Hao-fei, SUN Hai-bin, WANG Chuan, ZHAO Jian-hui
    2016, 37(4):  392-396.  doi:10.3969/j.issn.10073205.2016.04.006
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    [
    Abstract ] Objective Toinvestigatetherelationship betweenthe high expression of
    intercellularadhesionmolecule-1 ( ICAM-1 ) andearlyacutelunginjuryofratswithsevereacute
    pancreatitis.Methods FortyhealthyadultmaleSDratsweredividedintotwogroupsaccording
    toarandomnumbertable : studygroup ( n =30 ) andcontrolgroup ( n =10 ) .Thestudygroupof
    ratweregiven0.1 mL / 100g4% sodiumtaurocholateuniformlyinjectedthroughbileduct ,
    whilethecontrolgroupofratsweregiveninjectsalineuniformlyinjectedthroughbileduct , and
    thenthebloodamylaseenzymesandbloodgaschanges , pulmonary watercontainingrate ,
    myeloperoxidase ( MPO ) activity , lungandpancreatichistologicalscores , theexpressionof
    ICAM-1inlungofthetwogroupsofratswereanalyzed.Results Incomparisonwithcontrol
    groups , bloodamylase , partialpressureofcarbondioxideinarterialblood
    ( PaCO 2 ) levels ,
    pulmonarywatercontainingrate , MPOactivity , lungandpancreatichistologicalscores , lung ICAM-1integratedopticaldensityvaluesinthestudygroupat3h , 6h , 12hweregradually
    increased ( P <0.05 ), theoxygenationindex , PaO 2 levels weredecreased ( P <0.05 ); In
    comparisonwithcontrolgroups , theserumamylase , PaCO 2 level , pulmonarywatercontaining
    rate , MPOactivity , lungandpancreatichistologicalscoresandareaoflungICAM-1inthestudy
    groupweresignificantlyhigherthanthatincontrolgroup ( P <0.01 ), However , theoxygenation
    index , PaO 2 , integratedopticaldensityvaluesweresignificantlyreducedinstudygroup ( P <
    0.01 ) .Conclusion HighexpressionofICAM-1caneasilyleadtoearlyacutelunginjuryofrats
    withsevereacutepancreatitis.
    Expression and significance of Glypican-3 in prostate cancer
    LIYong,ZHAOXin-hong,MENGXiao-dong, CHENTao,LiuJian,QIUJian-hong*
    2016, 37(4):  397-399.  doi:10.3969/j.issn.10073205.2016.04.007
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    [
    Abstract ] Objective Toinvestigatetheexpressionandsignificanceofglypican-3 ( GPC-3 ) in
    prostatecancer.Methods Atotalof30casesofprostatecancertissuesand30casesofbenign
    prostatichyperplasiatissues wereincludedinthestudy withtheimmunohistochemicalS-P
    methodtodetecttheexpressionofGPC-3inprostatecancerandbenignprostatichyperplasia.
    Results ThepositiveratesofGPC-3expressioninprostatecancertissueswassignificantlyhigher
    thanthatin benign prostatichyperplasiatissues ( P <0.05 ) .Thepositiveratesof GPC-3
    expressioninprostatecancertissueswithgleasonscoreequaltoormorethan7wassignificantly
    higherthanthatwithgleasonscorelessthan7 ( P <0.05 ) .Conclusion HighexpressionofGPC-
    3inprostatecancermayplayanimportantroleindevelopmentofprostatecancer.
    The therapeutic effect observation of the ultrapulsed CO2 laser in combination with Q-switch 532 nm laser on the treatment of the seborrheic keratosis
    HAN Lan-qin， ZHANG Chui, ZHANG Jia-yu
    2016, 37(4):  400-403.  doi:10.3969/j.issn.10073205.2016.04.008
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    [
    Abstract ] Objective Toevaluatethetherapeuticeffectandthesafetyofultra-pulsedCO 2
    laserincombinationwiththeQ-switch532nmlaseronthetreatmentoftheseborrheickeratosis.
    Methods Threehundredandseventy-fivecasesofoutpatientsdiagnosedasseborrheickeratosis
    weredividedintothreegroupsequally , with125casesineachgroup.Treatmentgroupwastreated
    withtheultra-pulseCO 2 laserandQ-switch532nmlaser.Controlgroup1wastreatedwiththe
    ultra-pulseCO 2 .Controlgroup 2 wastreated with the multifunctionalelectricion therapy
    apparatus.Results Theone-timecurerateintreatmentgroupwas96.8% , higherthanthatof
    83.2%incontrolgroup1and78.4%incontrolgroup2 , thedifferencewasstatisticallysignificant
    (
    P <0.05 ) .Generalcomplicationswerelowerintreatmentgroupthanthatcontrolgroup2 ( P <
    0.05 ) .Thenumberoftotalcasesofcomplicationsintreatmentgroup waslessthancontrol
    group.Andsuperficialscarincidencewas0.0% intreatmentgroup , which wassignificantly
    lowerthanthatof7. 2%incontrolgroup2 , orthatof4.8%incontrolgroup1.Thedifference
    wasstatisticallysignificant ( P <0.05 ) .Theincidenceoftemporarypigmentationwasstatistically
    significantdifferenceamong3groups ( P <0.05 ), butthedifferencebetweentwogroupswasnot
    statisticallysignificant ( P >0.05 ) .Theincidenceofpigmentlossrateamong3groupswasnot
    statisticallysignificantdifference ( P >0.05 ) .Conclusion UltrapulseCO 2 lasercombinedwiththe
    Q-switch532nmlaserintreatmentofseborrheickeratosisisasafeandeffectivemethod , which showsasignificantreducedincidencerateofsideeffects.
    One stage debridement for the treatment of lumbar vertebral tuberculosis
    DONG Zhao-liang1,YAO Xiao-wei1, LIU Feng-sheng1, YAO Li-ming1，LI Ye-tong2, JIA Chen-guang1* 
    2016, 37(4):  404-406,411.  doi:10.3969/j.issn.10073205.2016.04.009
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    [
    Abstract ] Objective Toevaluatetheclinicalvalueofonestagedebridementforthe
    treatmentoflumbarvertebraltuberculosis.Methods Twenty-onepatientswithsinglevertebral
    spinaltuberculosisweretreatedbyone-stagefocidebridement , whosetreatmentandefficacy
    werereviewedretrospectively.Results Allpatientswerefollowedupwellforanaverageof18. 5
    months.Thespinaltuberculosisof21patientswereallcuredwithoutrelapse.Thefusiontimeof
    intervertebralgraftwererangedfrom3to10months , withaveraged5. 2±1.3months.After2
    weeksandthelastfollow-up , VASscoreanderythrocytesedimentationratewerestatistically
    significant ( P <0.01 ) .Conclusion Thecurativeeffectofonestagedebridementforthetreatment
    oflumbarvertebraltuberculosisispositive , andtherecoveryisfast.Onestagedebridement
    treatmentoflumbarvertebraltuberculosisisaneffective methodfortreatmentoflumbar
    vertebraltuberculosis , itisworthyofclinicalapplication.
    Effects of 2-Methoxyestradiol on growth, invasion and migration of malignant melanoma B16cells
    HU Cai-xia1, FENG Jia2, LV Li-jing1, GAO Shun-qiang1, WANG Wen-qing1, ZHANG Guo-qiang1*
    2016, 37(4):  407-411.  doi:10.3969/j.issn.10073205.2016.04.010
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    [
    Abstract ] Objective Toobservetheeffectsof2-methoxyestradiol ( 2-ME ) onproliferation ,
    invasion , migrationofmalignantmelanoma ( MM ) B16cells.Methods MMB16cellsculturedin
    vitrowereregardedasthecontrolgroup.MMB16cellsweretreatedwithdifferentconcentrations
    of2-ME ( 10 , 20 , 40 μ mol
    / L ) .MMB16cellswererecordedinMMB16-negativecellswithoutany
    treatment.MorphologicalchangesofMMB16cellswereobservedbyinvertedmicroscopeafter48
    h.Theplatecolonyassaywasusedtotestifythecolony-formationabilityofMMB16cellstreated
    with2-methoxyestradiolfor2 weeks.Thetranswellassay wasusedtodetectthecapacityof
    invasion and migration of MM B16 cells treated with 2-methoxyestradiolin different
    concentrations.ThewoundhealingassaywasusedtotestifythecapacityofmigrationofMMB16
    cellstreatedwith2-MEattheconcentrationsof10 μ mol
    / Lfor24h.Results Comparedwiththe
    controlgroupthecolony-formationabilityofMM B16cellstreatedwith2-MEwassignificantly inhibited ( P <0.05 ) .ThecapacityofinvasionandmigrationofMM B16cellstreatedwith2-ME
    wasinhibitedcomparedwiththecontrolgroup ( P <0.05 ) .Thecellsinthecontrolgroupalmost
    migratedtoallthescratches.Onlysomescratchesareaswereoccupiedbycellsinthe10 μ mol
    / L
    experimentalgroup.Conclusion 2-MEcouldinhibittheproliferationofMM B16cellinatime-
    dose-dependentmanner.2-MEcouldinhibitthecloningabilityof MM B16cell.2-MEcould
    inhibitthecapacityofinvasionandmigrationofMMB16cell.
    Influence of different concentrations of contrast agents on the image quality by prospective ECG-gated 256-slice coronary CTA technique
    YIN Lan-ying， LI Meng-ya， LI Cai-ying*， KOU Chen-guang， WANG Ceng, HUANG Ya-fei
    2016, 37(4):  412-415.  doi:10.3969/j.issn.10073205.2016.04.011
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    [ Abstract ] Objective Toevaluatetheinfluenceofdifferentconcentrationsofcontrastagents
    onimagequalitybyprospectiveECG-gated256-slicecoronaryCTangiography ( CTA ) .Methods
    NinetypatientssuspectedcoronaryheartdiseaseunderwentprospectiveECG-gated256-slice
    coronaryCTA.Thosepatients wererandomlydividedintothreegroups : group A ( Iohexol
    injection300mgI / mL ), groupB ( Iohexolinjection320mgI / mL ) andgroupC ( Iohexolinjection
    350mgI / mL ) .Thedosageofcontrastagentwas0.8 mL / kgbody weight.Coronaryimage
    quality , imagesignalnoiseratio ( SNR ), imagecarriertonoiseratio ( CNR ) andamountof
    contrastagentwerecomparedamongthreegroups.Results There were371 , 368and365
    coronarysegmentsingroupA , BandC , respectively.GroupCwassignificantbetterinsubjective
    imagescore , theevaluationrateofcoronarysegmentsandexcellentrateofimagequality ( P <
    0.01 ), andwashigherinaorticCTvalueandinCNRthanthoseingroupAandB ( P <0.05 )However , therewasnotsignificantdifferenceinSNRamongthreegroups ( P >0.05 ) .Thetotal
    mediumdosageofcontrastagentingroupA wassignificantlowerthanthatingroupC ( P <
    0.05 ) .Conclusion LowconcentrationsofcontrastagentswithprospectiveECG-gated256slice
    coronaryCTAisfeasibleinpatients , whichcanreducetheradiationdoseandsideeffectsof
    contrastagentaswellasmaintaindiagnosticimagequality.
    Diagnostic significance of arterial spin labeling in the assessment of tumor grade in brain
    WANG Yu-fang, HOU Bo, ZHANG Xiao-rui, ZHANG Min, YANG Su-jun, XIANG Shi-feng
    2016, 37(4):  416-421.  doi:10.3969/j.issn.10073205.2016.04.012
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    [
    Abstract ] Objective Toassessthearterialspinlabeling ( ASL ) perfusionimagingmeasurement
    ofcerebralbloodflow ( CBF ) inpatientswithbraintumors , andassessingpreoperativetumorgradein
    brain.Methods PubMed , WebofScience , Embase , ChinaBioMedicine ( CBM ), CINAHL ,
    CochraneLibrary , andChinaNationalKnowledgeInfrastructure (
    CNKI ) databaseswerechosen
    toevaluatetheassociationsbetweenASLandbraincancer.Thequalityoftheincludedtrialswas
    evaluated.Standardizedmeandifference ( SMD ) at95% confidenceinterval ( 95% CI ) wasalso
    calculated.Results FourhundredsandseventyfivepatientswereenrolledintothisMeta-analysis
    from12eligiblestudiesandwereselectedforstatisticalanalysis.Resultsshowedthatrelative
    tumorbloodflow ( rTBF ) andrelativecerebralbloodflow ( rCBF ) inhigh-gradebraincancer
    patientswerefasterthanthoseinlow-gradebraincancerpatients.Subgroupanalysisstratifiedby
    countryimpliedthatASL maybethe mainpredictionofincreasedrTBFinhigh-gradebrain
    cancerpatientsamongUSA , KoreaandChina ; andrCBFwasfasterinhigh-gradebraincancer
    usingASLinUSAandinChina.Furtherreferencebytissue-stratifiedanalysisrevealedapositive
    associationofrTBF withhigh-gradebraincancerbyutilizationofASLinalltheexperimental
    subgroups , whilerCBF wasonlycorrelatedin whitesubgroups.Conclusion TheseresultsshowedthatrTBFandrCBFwerefasterinhigh-gradebraincancerpatients , suggestingthatASL
    mayprovidesuitablemeasurementforthedifferentialdiagnosisoftumorgradeinbrain.
    Myelin and axonal injury in patients with obstructive sleep apneahypopnea syndrome
    CAO Qi-zhen, NIU Cai-hong, QI Jin-chong, WEI Rong-chen, YANG Ji-ping*, GENG Zuo-jun
    2016, 37(4):  422-426.  doi:10.3969/j.issn.10073205.2016.04.013
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    [
    Abstract ] Objective Theaim ofthisstudywastoexplorethebrain myelinandaxonal
    injuryinpatientswithobstructivesleepapnea-hypopneasyndrome ( OSAHS ) using magnetic
    resonancediffusiontensorimaging ( DTI ) .Methods Twenty-sixmalepatientswithOSAHSand
    twenty-twomalehealthycontrolsmatchedforageandgenderwereincludedinthisstudy.Two
    groupswereallmales.Conventionalbrainmagneticresonanceimaging ( MRI ) andDTIscanswere
    performed.TheDTIdatawereprocessedwiththeDTIStudio , thesoftwareofRESTandSPM8
    onthe Matlab.Weusedvoxel-basedanalysis ( VBA ) todeterminethedifferencesofaxial
    diffusivity ( AD ) andradialdiffusivity (
    RD ) valuesbetweentotwogroups.Andatlast , itwas
    concludedthebrainreqionsandclustersizeswithstatisticallysignificantdifferencebetweeninthe
    twogroups.Results Comparedwiththecontrolgroup , ADandRDvaluesofexperimentalgroup inthebrainregionsweresignificantlydecreased ( P <0.01 ) .TheregionsdecreasedADvalues
    weremainlylocatedinthefrontalgyrus , parietallobule , anteriorcingulate , posteriorcingulate ,
    brainstem , ventrallateralnucleus , corpuscallosum , hippocampus , cerebellumandsoon.The
    regionsofdecreasedRDvaluesweremainlylocatedinthefrontalgyrus , parietallobule , temporal
    lobe , posteriorcingulate , brainstem , ventrallateralnucleus , corpuscallosum , hippocampus ,
    cerebellum , insula , precuneusandsoon.Conclusion TheADandRDvaluesofmultiplebrain
    regionswithOSAHSpatientsweresignificantlylowerthanthoseinnormalvolunteers , which
    confirmedthatthewhitematterhadawiderangeofdamage.Thewhitemattermicrostructure
    couldbequalitativelyanalyzedusingDTIbasedontheVBA method , whichcouldevaluatebrain
    whitematterlesioninOSAHSpatiens
    Clinical study of dualsource CT perfusion imaging in liver metastases before and after treatment of TACE
    JIA Yan-bin1， WANG shu-hang1, QI Xiao-hui2， LIU Jing2， WANG Wei-na1, SHI Gao-feng2*
    2016, 37(4):  427-430.  doi:10.3969/j.issn.10073205.2016.04.014
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    [ Abstract ] Objective Tostudytheapplicationofdual-sourceCT perfusionimagingin
    evaluatingthe effect oftranscatheter hepatic arterialchemoembolization ( TACE ) ofliver
    Metastases , byanalyzingtheparameterofhemodynamiccharacteristicbeforeandafterTACE.
    Methods 28patientswithhepaticmetastaseswereincludedinthestudy.Allthepatientswere
    underwentduai-sourceCTperfusionimagingscansbeforeandafterTACE ( rangefrom25-35d ) .
    TheCTperfusionparametersoflivermetastasesandsurroundingnormalliverparenchymabefore
    andafterTACE weremeasured.Results BeforeTACEthehepaticarterialperfusion ( ALP ),
    hepaticperfusionindex ( HPI ), portalveinperfusion ( PVP ) ofthelivermetastaseswerehigher
    thanthatofsurroundingnormalliverparenchyma , whilethebloodflow ( BF ), bloodvolume
    (
    BV ), permeabilitysurface ( PMB ) werelower ( P <0.05 ) .AfterTACEtheBF , BV , PM , ALP
    oflivermetastaseswerelowerthanthatofbeforeTACE , andthePVP , HPIoflivermetastases
    werehigherthanthatofbefore TACE ( P <0.05 ) .After TACE , the PVP , HPIofliver metastaseswerehigherthanthatofsurroundingnormalliverparenchyma , whiletheBF , BV ,
    PMB , ALPwerelower ( P <0.05 ) .Conclusion Dual-sourceCTperfusionimagingcanobjectively
    reflectthehemodynamiccharacteristicsoflivermetastases , andevaluatethebloodsupplyofliver
    metastasesbeforeandafterhepaticarteryembolismchemotherapy , providingvaluableguidance
    forclinicaltreatment.
    Diagnosticvalueof 18 F-FDGPET / CTinbenignandmalignantpancreaticlesions
    ZHENG Li-chun1, ZHANG Wen-jun1, OUYANG Xiang-liu2， LIU Gui-chao1, ZHANG Zhi-yong3, ZHANG Xiao-ming1*
    2016, 37(4):  431-434,439.  doi:10.3969/j.issn.10073205.2016.04.015
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    [
    Abstract ] Objective Toinvestigatethediagnosticvalueofpositronemissiontomography /
    computedtomography ( PET / CT )
    18 F-fluorodeoxyglucose ( 18 F-FDG )
    indiagnosisofbenignand
    malignantpancreaticlesions.Methods Retrospectiveanalysisfor53pancreaticpatientswith57
    lesionswhohadbeenexaminedby
    18 F-FDGPET
    / CTwasperformed.Theresultswereconfirmed
    bypathology orfollow-up with clinicandimaging.Maximum standardized uptake values
    (
    SUVmax ) ofbenignand malignantpancreaticlesionswerecompared , andreceiveroperating
    characteristic ( ROC ) curveofSUVmaxindiagnosisofmalignantpancreaticlesionswereanalyzed.
    Thesensitivity , specificity , accuracy , positiveandnegativepredictivevalueof
    18 F-FDGPET
    / CT
    indiagnosisofbenignandmalignantpancreaticlesionswerecalculated.Results Therewere35
    malignant ( 35 / 57 , 61.40% ) and22benign ( 22 / 57 , 38.60% ) in57pancreaticlesions.TheSUVmax ofmalignantandbenignpancreaticlesionswere3. 88±2.04and2. 09±0.94 , respectively ( t =
    4.481 , P <0.01 ) .TheROCareaundercurveforSUVmaxindiagnosisofmalignantpancreatic
    lesionswas0.872 ( 95% CI : 0. 771~0.973 , P <0.01 ) .WhentheSUVmaxwas2.42 , thesumof
    thesensitivityandthespecificitywasmaximumof1.709.Thesensitivity , specificity , accuracy ,
    positivepredictivevalueandnegativepredictivevalueof
    18 F-FDG PET
    / CTin diagnosisof
    malignantpancreaticlesionswere85.71% ( 30 / 35 )、 81.82% ( 18 / 22 )、 84.21% ( 48 / 57 )、 88.24%
    (
    30 / 34 )、 78.26% ( 18 / 23 ), respectively.Conclusion  18 F-FDG PET / CTisagoodtechniquein
    diagnosisofbenignandmalignantpancreaticlesions.
    Effect of 5% multiple electrolytic and invert sugar injection on the energy metabolism in patients of elective craniotomy
    LIU Yue1， LI Xiao-yun1， KANG Rong-tian1*， HAN Jin-li2
    2016, 37(4):  435-439.  doi:10.3969/j.issn.10073205.2016.04.016
    Asbtract ( 499 )   PDF (394KB) ( 137 )  
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    [
    Abstract ] Objective Toobservetheeffectofmultipleelectrolyticandinvertsugarinjection
    onbloodglucose , insulin , C-peptide , baseexcess ( BE ), freefattyacidsinpatientsundergoing
    operationofneurosurgery.Toevaluatetheeffectonenergymetabolisminpatientsandprovide
    experienceforclinicalapplication.Methods Sixtypatients , ASA Ⅰ-Ⅱ , anesthetictimemore
    than6hoursundergoingelectivecraniotomywererandomlydividedintothreegroups : invert sugar ( IS ) group , glucose ( GS ) group , normalsaline ( NS ) group ( n =20 ) .Thepatients'vitalsigns
    weremonitoredsuchasnon-invasivebloodpressure , heartrate ( HR ), electrocardiogram , oxygen
    saturation , thedepthofanesthesia ( BIS ) inoperatingroom.Afteropenningtheveinliquidpath ,
    theanesthesia wasinduced.The patients underwent trachealintubation and mechanical
    ventilation.Therightfemoralveinwaspunctured , anddorsalispedisarterypunctureofinvasive
    arterialbloodpressurewasmonitored.Afterthecirculationstability , GS , IS , NSgroupswere
    givensodiumchlorideandcextroseinjection500mL , 5% multipleelectrolyticandinvertsugar
    injection500mLand500mLphysiologicalsalineinonehour , thennosugaryliquidwasgiven.
    Bloodglucose , bloodinsulin , C-peptide , freefattyacidconcentrationsand BE value were
    measuredatthetimeof0hour ( T 0 ) beforethecorrespondingfluidinfusion , infusionof250mL
    ( T
    1 ), 0hourafterinfusion ( T 2 ), 1hoursafterinfusion ( T 3 ), 3hoursafterinfusion ( T 4 ) .Ifthe
    measuredbloodglucoseconcentrationishigherthan10 mmol
    / LatT
    3 , thenthatcasewillbe
    excludedinthestudyandwillbetreatedwithinsulinformeasuringbloodglucose.Thepatients'
    gender , age , weight , BMI , blood pressure , HR , BISimmediatelyatdrawing blood were
    recorded.Bleedingandinfusion withliquidin operation wereamounted.Thenumberand
    percentageofpatientswhogotadditionalinsulinwasamounted.Results Thebloodglucosewas
    increasedfromT 0 , reachedthepeakatT 1 andwasdecreasedtoT 4 inthethreegroups.Butthe
    increasedextentwasdifferent.Theinsulin , C-peptideinthethreegroupswereallincreasedand
    thendecreased.ThepeakincreasedinISandGSgroupwasatT 2 , butintheNSgroupwasatT 1 ;
    BEvaluesinISgroupandGSgroupweredecreasedgraduallyfromT 0 -T 3 andwereincreasedat
    T 4 .In NSgroupBE values weredecreasedfrom T 0 -T 3 andincreasedatT 4 .There were
    statisticallydifferencesinthebloodglucose , insulin , C-peptideandBE valuesinthethree
    groups , thetimepoint , andtheinteractionofgroupsandtimepoints (
    all P <0.01 ) .The
    trendencyoffreefattyacidsinthethreegroupswerewithrisingandfallingtrendoffluctuations.
    Buttherewerenostatisticallydifferencesinthethreegroups , thetimepoint , theinteractionof
    groupsandtimepoints ( P >0.05 ) .Conclusion Infusionof5% multipleelectrolyticandinvert
    sugarinjectionwillcausetheincreasmentinbloodglucose , insulin , C-peptidelevels , butitisin
    clinicalallowedrange , whichwillbegoodtoprovideenergyforpatientwithelectivecraniotomy.