The clinical study on the effect of dexmedetomidine and remifentanil combined anesthesia with laryngeal mask in pediatric department of ophthalmology surgery
WANG Hong1, WANG Yuexin2, ZHAO Jianhui1, SONG Tieying1, GU Kunfeng1
2016, 37(9):
1060-1063,1068.
doi:10.3969/j.issn.10073205.2016.09.017
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Abstract ] Objective Toanalyzethehemodynamiceffectsandclinicalresponseindexof
dexmedetomidineandremifentanilcombinedanesthesiainpediatricdepartmentofophthalmology
surgerywithlaryngealmaskduringperioperativeperiod.Methods The120casesofpatients
comingfromthepediatricophthalmicsurgery wererandomlydividedintothreegroupswith
envelopemethod , asforremifentanilanesthesiagroup , dexmedetomidineanesthesiagroup , the
combinedgroup ( dexmedetomidineandremifentanilcombinedanesthesia
), whichwerefortycases
ineachgroup.Respectivelybeforeinduction ( T 0 ), fiveminutesafterinduction ( T 1 ), laryngeal
maskinsertion ( T 2 ), intrasurgery ( T 3 ), pullouttube ( T 4 ), 5minafterpullouttube ( T 5 ), The
levelsofmeanarterialpressure ( MAP ), respiration ( RR ), heartrate ( HR ) wereseparately
monitored.Beforeinduction ( T 0 ), intrasurgery ( T 3 ) andfiveminutesafterextubation ( T 5 ), the
levelsofcortisolconcentration ( COR ) andnorepinephrine ( NE ) invenousbloodweredetected. Theindexesoflaryngealmaskinsertiontime , theone-timeinsertionoflaryngealcoversuccess
rate , coughchokereactionrate , spontaneousbreathingrecoverytime , removaloflaryngealmask
airwaytime , waketime , emergencedelirium occurrencerate , nausea , vomitingincidencewere
recordedandcomparedamongthreegroupsofpatients.Meanwhile , itwasdonetofurther
comparetheclinicaladversereactionswithinperioperative.Results ThelevelsofMAP , RR , HR ,
CORandNEamongthreegroupsofpatientswerenotstatisticallysignificantatdifferenttime
pointsandatdifferenttimepointsandtheinteractionbetweendifferentgroupsanddifferenttime
pointswasalsonotstatisticallysignificant ( P >0.05 ) .Thespontaneousbreathingrecoverytime
andtheremovaltimeofthelaryngealmaskinthedexmedetomidinegroupwerelessthanthe
remifentanilgroup.butthewaketimeinthedexmedetomidinegroupwaslongerthanthatof
remifentanilgroup ( P <0.05 ) .Thelaryngealmaskinsertiontime , recoverytimeofspontaneous
breathing , theremovaltimeofthelaryngealmaskinthecombinedgroupwereshorterthanthe
remifentanilgroupandthedisposablesuccessrateofthelaryngealmaskinsertionwashigherthan
theremifentanilgroup.theincidenceratesofnauseaandvomitingwerelessthantheremifentanil
group , thelaryngealmaskinsertiontime , theremovaltimeofthelaryngealmaskandwake-up
timewereshorterthanthedexmedetomidinegroup ( P <0.05 ) .Theincidencerateofcough
responseanddeliriumamongthreegroupsshowednosignificantdifference ( P >0.05 ) .Conclusion
Remifentanilanddexmedetomidinecombinedanesthesiacouldhelptostabletheperioperative
hemodynamicparameters , reducesurgicalstressresponseand decreasetherateofadverse
reactionsduringlaryngeal maskinsertionand pulltubetimeforthepatientsofpediatric
ophthalmology with laryngeal mask anesthesia.The clinicaleffectis betterthan that of
remifentanilordexmedetomidinefixedmedicationalone.