Loading...

Table of Content

    25 September 2018, Volume 39 Issue 9
    Previous Issue    Next Issue
    Effect of illness perception on discharge of patients with acute myocardial infarction
    SUN Zhifei, XU Zhong, XIN Li, WANG Bosong, SUN Weidong, LI Jinlong*
    2018, 38(9):  996-1001.  doi:10.3969/j.issn.10073205.2018.09.002
    Asbtract ( 592 )   PDF (424KB) ( 193 )  
    Related Articles | Metrics
    ［Abstract］〓Objective〖HTSS〗〓To enhance disease perception of acute myocardial infarction in patients with acute myocardial infarction through health education,and to explore the impact of disease perception on patient discharge.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 107 patients with the first acute myocardial infarction were randomly divided into control group(53 cases) and experimental group(54 cases). Patients in the experimental group were educated according to the slides drawn up by the special books of the cardiology department and related guidelines. However, the control group was educated based on the nurses usual health education contents. The Hospital Anxiety Depression Scale(HADS), the World Health Organization Quality of Life Questionnaire(WHOQOLBREF), and the Brief Illness Perceptions QuestionnaireRevised(BIPQR) were used to assess patients before education and in the first, third, and sixth months after discharge. Also, the number of reinfarctions, rehospitalizations, and deaths after discharge were counted.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The HADS anxiety and depression scores in the control group showed a gradually increasing trend. The HADS anxiety and depression scores in the experimental group showed a tendency to decrease gradually. The HADS anxiety and depression scores in the experimental group were lower than those in the control group. Two groups of WHOQOLBREF physiology, psychology, social relations, environmental field scores and BIPQR scores showed a trend of decreasing gradually. The WHOQOLBREF of the experimental group scored was higher in the physiological field, psychological field, social relations field, and environmental field than the control group, while the BIPQR score was lower than the control group. There was a statistically significant difference between groups, time points, time and time points(P＜005). The number of reinfarction cases at 1, 3 and 6 months after discharge from the two groups and the number of rehospitalization cases at 1, 3 and 6 months after discharge were not statistically significant(P＞005). The total number of rehospitalization in the experimental group was significantly lower than that in the control group(P＜005). No deaths were found during followup.
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The health education of patients with acute myocardial infarction by a cardiology specialist can improve the patient′s perception of disease, improve anxiety, depression, quality of life and reduce the readmission rate in patients with acute myocardial infarction, but has no significant effect on reinfarction rate and mortality.
    Comparison of effects of different doses of spironolactone in treating heart failure of ischemic cardiomyopathy#br#
    LU Zhike1， SUN Rong2*
    2018, 38(9):  1002-1006.  doi:10.3969/j.issn.10073205.2018.09.003
    Asbtract ( 823 )   PDF (386KB) ( 191 )  
    Related Articles | Metrics
    ［Abstract］〓Objective〖HTSS〗〓To observe the effects of different doses of spironolactone on cardiac structure and function in patients with heart failure of ischemic cardiomyopathy.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The  120 patients with ischemic heart disease and heart failure were selected as study subjects. According to the random number table method, they were divided into control group, lowdose spironolactone group, middledose spironolactone group, and largedose spironolactone group, with 30 cases in each group. The control group given conventional treatment, lowdose spironolactone group plus 10 mg spironolactone, mediumdose spironolactone group with 20 mg spironolactone, highdose spironolactone group plus 40 mg spironolactone. The left ventricular ejection fraction(LVEF), left ventricular endsystolic diamete(LVESD), left ventricular enddiastolic diameter(LVEDD), nocardial function classificationin New York Heart Association(NYHA), Nterminal proBtype natriuretic peptide(NTproBNP), cardiac troponin T(cTnT), high sensitivity Creactive protein(hsCRP), tumor necrosis factorα(TNFα), procollagen type Ⅲ nitrogen terminal peptide(PⅢNP)， 6 min walking distance and clinical efficacy were compared among different groups.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The clinical efficacy of the middledose spironolactone group was better than that of the control group, and the total treatment efficiency was higher than that of the control group(P＜005).After treatment, the levels of NTproBNP, cTnT, hsCRP, TNFα, and PⅢNP in the 4 groups were lower than before treatment.The levels of NTproBNP, hsCRP, TNFα, and PⅢNP in lowdose spironolactone group, middledose spironolactone group, and largedose spironolactone group were lower than those in the control group. The level of cTnT in the middledose spironolactone group was lower than that in the control group. The levels of NTproBNP, hsCRP, TNFα, and PⅢNP in the middledose spironolactone group were lower than those in the lowdose spironolactone group and the highdose spironolactone group(P＜005).The LVEF value and 6 min walking distance of the 4 groups were greater than before treatment. The LVESD value, LVEDD value and NYHA functional class were less than before treatment. The LVEF value and 6 min walking distance of smalldose spironolactone group, middledose spironolactone group, and largedose spironolactone group were greater than those of the control group. NYHA cardiac function was less than the control group. The LVEDD value of the middledose spironolactone group was lower than that of the control group, and the NYHA heart function of the middledose spironolactone group. The grading was smaller than that of the smalldose spironolactone group and the largedose spironolactone group, and 6 min walking distance was greater than that of the smalldose spironolactone group and the highdose spironolactone group(P＜005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Compared with the 10 mg and 40 mg dose groups, the 20 mg dose of spironolactone can effectively control the ventricular remodeling in patients with ischemic cardiomyopathy heart failure, which will benefit the improvement of cardiac function and is worthy of clinical application.
    Study on the correlation between H type hypertension and coronary heart disease#br#
    ZHANG Yu1, LYU Xinhu2*, LIN Wenjing1, CHEN Shen1, LI Qing1, ZHAO Tianran1
    2018, 38(9):  1007-1009,1016.  doi:10.3969/j.issn.10073205.2018.09.004
    Asbtract ( 498 )   PDF (381KB) ( 126 )  
    Related Articles | Metrics
    ［Abstract］ Objective〖HTSS〗〓To investigate the relationship between H type hypertension and coronary heart disease(CHD).
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 357 patients who were hospitalized in the department of cardiology and underwent coronary angiography examination were collected. According to the results of coronary angiography, they were divided into CHD group and non CHD group. plasma homocysteine(Hcy) values was determinated. Based on plasma Hcy value, basal blood pressure and coronary angiography results, we investigated the relationship between H type hypertension and CHD.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The Hcy level of the CHD group was significantly higher than the non CHD group(P＜005). The incidence of high Hcy, hypertension and H hypertension of the CHD group were higher than the non CHD group, the differences were statistically significant(P＜005). The homocysteine level and Gensini score of the AMI group were significantly higher than the SAP and UAP group. The differences were significant(P＜005). Hcy single factor correlation analysis showed that the Hcy level  was correlated with Gensini score, and the difference was statistically significant(r=0743, P=0000), through multiple regression analysis, the H type hypertension was selected as one of the CHD. Other independent risk factors were not independent risk factors for CHD.
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The level of Hcy in patients with CHD is higher than that of the non CHD. H type hypertension is an independent risk factor for coronary heart disease.
    Study on the protective effect of Xuebijing on lung injury in rats with acute paraquat poisoning#br#
    WANG Xin
    2018, 38(9):  1010-1016.  doi:10.3969/j.issn.10073205.2018.09.005
    Asbtract ( 521 )   PDF (1913KB) ( 145 )  
    Related Articles | Metrics
    ［Abstract］〓Objective〖HTSS〗〓To explore the mechanism of Xuebijing in the treatment of acute paraquat poisoning by studying the effects of Xuebijing on the activity of superoxide dismutase(SOD) and glutathione peroxidase(GSHPX), the content of malonaldehyde(MDA) and the expression of tumor necrosis factorα(TNFα)， interleukin10(IL10) in acute paraquat lung tissue.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓On the base of random number table,108 Wister rats were divided into control group(36 rats), poisoned group(36 rats), treatment group(36 rats). On 1 st, 3 rd, 7 th, 14 th, 21 st and 28 th day，six rats from each group were anaesthetized by intraperitoneal injection of chloral hydrate. Open chest under ether anesthesia and leave the right lower lung tissue specimens to measure the activity of SOD and GSHPX and the content of MDA. The expression levels of TNFα,  IL10 in lung tissue were detected by immunohistochemical staining.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The activity of SOD in the poisoned and treatment group increased gradually along the length of time(P＜005). The activity of SOD in each time point of the poisoned group was lower than that of the control group(P＜005). The activity of SOD in the treatment group was higher than that of the infected group, but it was still lower than that of the control group(P＜005). The activity of GSHPX increased gradually along with the time in the poisoned and the treatment group(P＜005).The GSHPX activity in the poisoned and the treatment group was lower than that in the control group at all time points, and the GSHPX activity at each time point in the treatment group was higher than that in the poisoned group(P＜005). The MDA activity in the poisoned and the treatment group gradually was decreased along with the time length(P＜005). The MDA activity in the posioned and the treatment group at each time point was higher than that in the control group, and the MDA activity at each time point in the treatment group was lower than that in the posioned group(P＜005). The expression of TNFα protein and the content of IL10 in the lung tissue of the poisoned and the treatment group increased first and then decreased. The expression level of TNFα, IL10 protein in lung tissue of the poisoned and the treatment group was higher than that of the control group(P＜005). The expression level of TNFα, IL10 in lung tissue at each time point in the treatment group were lower than those in the exposure group(P＜005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Oxygen free radicals and cytokine TNFα, IL10 play an important role in lung injury induced by paraquat in rats. Xuebijing can reduce the injury of lung tissue in paraquatpoisoning rats.
    Multifactorial investigations on the factors and countermeasures for death anxiety of ICU nurses in provincial tertiary hospital in Hebei province#br#
    XUE Nana1, LIU Yufang1, XIAO Hemei2, ZHAO Shuyun1, LIANG Huizhen1, YU Fengxue3*
    2018, 38(9):  1017-1020,1025.  doi:10.3969/j.issn.10073205.2018.09.006
    Asbtract ( 490 )   PDF (413KB) ( 238 )  
    Related Articles | Metrics
    ［Abstract］ Objective〖HTSS〗〓To explore the influencing factors for death anxiety among intensive care unit(ICU) nurses in provincial tertiary hospitals in Hebei province, and to provide strategies for reducing it.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓ICU nurses from the tertiary hospitals in Hebei province were selected as subjects to investigate the status of death anxiety. The application of SPSS 19.0 software for the corresponding statistical analysis.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The death anxiety score of nurses aged ≤25 years was significantly lower than that of nurses >25 years old. The death anxiety score of male nurses in ICU was significantly lower than that of female nurses. The initial education degree of nurses was higher than that of undergraduate students in secondary school and junior college. The teacher's death anxiety score was higher than that of the nurses, and the difference was statistically significant(P＜005). The age of ≤25 years old, the experience of participating in the dying of relatives and the systematic training of hospice care are the “protective factors” of death anxiety. The anxiety score after training was lower than that before training and training, and the difference was statistically significant(P＜005). 
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The training of death anxiety system conducted by ICU nurses is worth promoting.
    Relationship between serum levels of IL18 and MMP9 and brain injury of hypertensive cerebral hemorrhage#br#
    ZHANG Jianhui， CAI Xinru， LI Peng， SUN Xiaoli， YAO Zhigang， JIA Weixian
    2018, 38(9):  1021-1025.  doi:10.3969/j.issn.10073205.2018.09.007
    Asbtract ( 482 )   PDF (403KB) ( 251 )  
    Related Articles | Metrics
    ［Abstract］〓Objective〖HTSS〗〓To analyze the relationship between serum levels of interleukin 18(IL18) and matrix metalloproteinase 9(MMP9) and brain injury of hypertensive cerebral hemorrhage.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The study group was 140 patients with hypertensive cerebral hemorrhage and the health group was 100 healthy volunteers. Serum levels of IL18 and MMP9 in two groups were detected. The 140 patients were divided according to Glasgow Coma Scale(GCS) scores, cerebral hematoma volume, and whether they were broken into ventricles to compare the levels of IL18 and MMP9 in different groups. According to the levels of IL18 and MMP9 at admission, the patients were divided into different groups to compare the prognosis of the high and low level groups after 3 months of treatment. The relationships between serum levels of IL18 and MMP9 at admission and GCS scores at admission, cerebral hematoma volume at admission, the National Institutes of Health Stroke Scale(NIHSS) score at 3 months after treatment, Glasgow Outcome Scale(GOS) score at 3 months after treatment and activity of daily living(ADL) score at 3 months after treatment were analyzed.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓Serum levels of IL18 and MMP9 in study group were higher than that of healthy group（P＜005）. Serum levels of IL18 and MMP9 in GCS 9-12 group were higher than that of GCS≥13 group and serum levels of IL18 and MMP9 in GCS≤8 group were higher than that of GCS≥13 group and GCS 9-12 group（P＜005）. Serum levels of IL18 and MMP9 in bleeding volume 30~50 mL group were higher than that of bleeding volume ＜30 mL group and serum levels of IL18, and MMP9 in bleeding volume ＞50 mL group were higher than that of bleeding volume ＜30 mL group and bleeding volume 30-50 mL group（P＜005）. The levels of IL18 and MMP9 in the ventricle hematocele group were higher than those in the non ventricle hematocele group（P＜005）. The GOS score and ADL score in the high IL18 group at 3 months after treatment were significantly lower than that in the low IL18 group, and NIHSS score was significantly higher than that in the low IL18 group（P＜005）. The GOS score and ADL score in the high MMP9 group at 3 months after treatment were significantly lower than that in the low MMP9 group, and NIHSS score was significantly higher than that in the low MMP9 group（P＜005）. The correlation analysis showed that the levels of IL18 and MMP9 were negatively correlated with the GCS score at admission, GOS score and ADL score at 3 months after the treatment（P＜005）  and positively correlated with hematoma volume at admission and NIHSS score at 3 months after treatment（P＜005）. 
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The serum levels of IL18 and MMP9 was increased rapidly in patients with hypertensive cerebral hemorrhage. And as the degree of brain injury increases, it increases, which affect the prognosis of the patients.
    Comparison of different kinds of internal fixation for sacroiliac joint dislocation:a finite element analysis#br#
    WU Tao, CHENG Xiaodong, CUI Yunwei, ZHENG Zhanle, LYU Hongzhi, ZHANG Yingze*
    2018, 38(9):  1026-1030.  doi:10.3969/j.issn.10073205.2018.09.008
    Asbtract ( 529 )   PDF (1738KB) ( 165 )  
    Related Articles | Metrics
    ［Abstract］ Objective〖HTSS〗〓To compare the biomechanical stability of three kinds of internal fixation for sacroiliac joint dislocation by threedimensional finite element analysis.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A healthy adult male was randomly seclected and the CT images of pelvis(1.0 mm thickness) were collected. Intact pelvis model and sacroiliac dislocation model were made using software of Mimics 10.01, Geomagic Studio 12, SolidWorks, Abaqus 6.111. Two iliosacral (IS) screws, the minimally invasive adjustable plate(MIAP) and the tension band plate(TBP) were used to fix the posterior pelvic ring respectively, and a loading of 500 N was put on the sacrum. Total displacement, strain value, stress distribution and the shift of dislocation gap of the whole model and internal fixator were compared.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The stress of upper body passed through sacral wing, bilateral sacroiliac joint, the large sciatic notch, arcuate line of the iliac bone to the bilateral acetabulum. Under 500 N load, displacements of the fixed models were two IS screws model(1.377 mm), the MIAP model(2.517 mm), and the TBP model(5.132 mm). The shifts of dislocation gap were two IS screws model(0.887 mm), MIAP model(2.502 mm) and TBP model(5.117 mm).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The stability of sacroiliac dislocation fixed with the MIAP was less than that fixed with the two IS screws, and better than that fixed with the TBP.
    The value of Xpert MTB/RIF in the early diagnosis of suspected spinal tuberculosis and the detection of rifampicin resistance#br#
    JIA Chenguang1, GAO Jianguo1, YAO Xiaowei1, WANG Lianbo1, YAO Liming1， LI Wen2*
    2018, 38(9):  1031-1033,1048.  doi:10.3969/j.issn.10073205.2018.09.009
    Asbtract ( 668 )   PDF (383KB) ( 266 )  
    Related Articles | Metrics
    ［Abstract］〓Objective〖HTSS〗〓To assess the value of Xpert MTB/RIF in the early diagnosis and drug resistance of suspected spinal tuberculosis.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Appling the Xpert MTB/RIF system to detect pus specimens from 168 suspected spinal tuberculosis surgery. Taking clinical diagnosis as the gold standard，the sensitivity and specificity of Xpert MTB/RIF for detection of Mycobacterium tuberculosis were calculated, and the differences in sensitivity and specificity between acidfast staining and rapid culture of Mycobacterium tuberculosis were compared.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓In the pus specimens of 168 patients with spinal tuberculosis, 134 cases of Xpert MTB/RIF were positive for Mycobacterium tuberculosis, of which 25 cases were resistant to rifampicin.Clinical diagnosis as the gold standard，the sensitivity of Xpert MTB/RIF for detecting Mycobacterium tuberculosis was 79.76%(134/168) and the specificity was 96.87%(47/50).There were 25 rifampicinresistant mutant genes in 134 cases of spinal tuberculous pus, and the drugresistant mutation rate was 18.66%. In the pus specimens of 168 patients with spinal tuberculosis, 51 cases were positive for acidfast staining  and 70 cases were positive for rapid culture of Mycobacterium tuberculosis.
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Xpert MTB/RIF is a molecular detection technique that can simultaneously detect mycobacterium tuberculosis and rifampicin resistance in spinal tuberculosis.It has high diagnostic value in the rapid diagnosis of spinal tuberculosis.
    Expression and clinical significance of VEGF, miR18a and MCM7 in uterus myoma tissues
    ZHANG Donghong， LIU Enling
    2018, 38(9):  1034-1037.  doi:10.3969/j.issn.10073205.2018.09.010
    Asbtract ( 658 )   PDF (371KB) ( 135 )  
    Related Articles | Metrics
    ［Abstract］ Objective〖HTSS〗〓To analyze the expression and clinical significance of vascular endothelial growth factor（VEGF）, microRNA18a（miR18a） and minichromosome maintenance 7（MCM7） in uterus myoma tissues.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The expression of VEGF, progesterone receptor （PR）, estrogen receptor （ER） and MCM7 of 43 uterus myoma tissues and perimyoma normal tissues were detected by immunohistochemistry,the expression of miR18a were detected by in situ hybridization method.The expression results were compared and analyzed.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The positive rates of  VEGF, PR, ER and MCM7 in uterus myoma tissues were significantly higher than those in perimyoma normal tissues,the positive rates of miR18a was significantly lower than those in perimyoma normal tissues(P＜0.05). The results of Spearman correlation analysis showed,the expression of PR,ER were positively correlated with the expression of VEGF, and MCM7(P＜0.05) were positively correlated with the expression of miR18a(P＜0.05).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓There are high expression of VEGF, MCM7 in uterus myoma,the expression of miR18a is low,It is closely related with the occurrence and development of myoma of uterus.
    Clinical effect of inhaled nitric oxide combined with high frequency shock ventilation on neonatal severe pneumonia#br#
    YANG Li， CHEN Yanhua， XU Fengling*
    2018, 38(9):  1038-1042.  doi:10.3969/j.issn.10073205.2018.09.011
    Asbtract ( 669 )   PDF (376KB) ( 103 )  
    Related Articles | Metrics
    ［Abstract］ Objective〖HTSS〗〓To investigate the clinical efficacy of inhaled nitric oxide(NO) combined with high frequency shock ventilation (HFOV) in the treatment of neonatal severe pneumonia. 
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓From January 2012 to December 2016, 54 children with severe neonatal severe pneumonia were enrolled in this study. They were randomly divided into observation group(inhaled NO combined with HFOV treatment) and control group(HFOV treatment), each group of 27 cases. The respiratory function index and blood gas index, and the lung function index after treatment and the time of disappearance of severe pneumoniarelated clinical signs were recorded before and 1 h, 6 h and 24 h after treatment.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The mean airway pressure(MAP), inspired oxygen volume fraction(FiO2), oxygenation index(OI), and a/A interaction between time points and between groups and time points in the two groups were statistically significant(P＜005). There was no significant difference between the groups(P＞005). The differences in arterial oxygen partial pressure(PaO2), carbon dioxide partial pressure(PaCO2), and pH between the two groups were statistically significant(P＜005). There was no significant difference between the groups(P＞005). The forced vital capacity(FVC), forced expiratory volume in one second(FEV1), and peak expiratory flow(PEF)after treatment in the observation group were significantly lower than those in the control group(P＜005). The time of disappearance of clinical signs such as threeindented sign, pulmonary rales, fever, cyanosis, and alar fan was significantly shorter in the observation group than in the control group. The difference was statistically significant(P＜005). 
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Inhaled nitric oxide combined with high frequency shock ventilation in the treatment of neonatal severe pneumonia can significantly improve the children′s respiratory function and blood gas index, and significantly improve the lung function and severe pneumoniarelated clinical signs, has a certain clinical application and research value.
    Questionnaire survey of visual quality of offflap LASEK surgery for correcting high myopia#br#
    ZHANG Hua1， WANG Chaoying2*， GAO Shaofang1， ZHAO Xin1， MI Jinyuan1， GAO Tiansi1
    2018, 38(9):  1043-1048.  doi:10.3969/j.issn.10073205.2018.09.012
    Asbtract ( 492 )   PDF (448KB) ( 165 )  
    Related Articles | Metrics
    ［Abstract］〓Objective〖HTSS〗〓To study the effect of the removal of the corneal flap on the visual quality of high myopia with laserassisted subepithelial keratomileusis(LASEK) in the treatment of high myopia.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 60 eyes of 30 cases of high myopia given LASEK operation were divided into two groups. In all of these cases, one eye had offflap LASEK operation randomly，and the other eye was applied onflap LASEK operation as onflap group. All cases were followed up for 1, 3, 5, 7 days and 1, 3, 6 months. To compare visual acuity, spherical equivalent, postoperation pains, corneal epithelium healing, questionnaire survey of visual quality were observed.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓At 3 months postoperatively, the number of eyes of increments 1 line of best corrected visual acuity were significantly higher in the offflap group than those in the onflap group（P＜005）. At 3 and 6 months postoperatively, the spherical equivalent in bost groups showed a decreasing trend of positive sphere with the change of time, and the difference between the two groups was statistically significant(P＜005). The scores of postoperative pain stimulation symptoms in bost groups showed a decreasing trend with the change of time, and were lower in offflap group than those in onflap group, and there were significant differences between the two groups(P＜005). Compared to the onflap group, outcomes for the offflap group showed a higher percentage of corneal epithelial healing at 3 and 5 days after surgery(P＜0.05). At 1, 3 and 6 months postoperatively, the changes of visual acuity fluctuation, halo and ghost symptoms in both groups showed a decreasing trend with the change of time(P＜005). The difference between the two groups was statistically significant in ghost and overall satisfaction scores(P＜005). At all the three time points, the ghost scores were lower in offflap group than those in onflap group, and the overall satisfaction scores were higher in offflap group than those in onflap group.
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Results of offflap LASEK for correcting high myopia showed the slighter stimulus pain and the shorter corneal epithelial healing time. The subjective visual quality was better and the overall satisfaction was higher in the early stage of offflap LASEK.
    Clinical analysis of acetylcysteine effervescent tablets for radiation pneumonitis prevention in nonsmall cell lung cancer#br#
    LU Xiurong, SONG Xiao, ZOU Niandong, ZHANG Xianyu,YUAN Na, ZHANG Zhilin
    2018, 38(9):  1049-1052.  doi:10.3969/j.issn.10073205.2018.09.013
    Asbtract ( 694 )   PDF (378KB) ( 199 )  
    Related Articles | Metrics
    ［Abstract］ Objective〖HTSS〗〓To explore the clinical values of acetylcysteine effervescent tablets in prevention of radiation pneumonitis for patients with nonsmall cell lung cancer(NSCLC).
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 68 consecutives as NSCLC were enrolled and divided randomly into control and observation groups, each with 34 cases, Control group was received intensitymodulated radiation, observation group was adopted oral acetylcysteine effervescent tablets. The differences of lung function forced expiratory volume in first second (FEV1), forced vital capacity(FVC), serum interleukin6(IL6), tumor necrosis factorα(TNFα) levels and the rates of radiation pneumonia and bone marrow suppression were compared.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The values of FEV1 and FVC in control group after treatment were lower than before treatment(P＜005),while there were no statistical difference in observation group(P＞005). The values of FEV1 and FVC in observation 〖JP2〗group were significantly higher than in control group after treatmen(P＜005). The levels of IL6〖JP〗 and TNFα in the two groups were higher than that before treatment(P＜005), but observation group were still significantly lower than control group after treatmen(P＜005).The incidences of 3~5 level radioactive pneumonia and bone marrow suppression in observation group were both significantly less than that in control group(14.7% vs 35.3%, 50.0% vs 79.4%, P＜005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓It can greatly alleviate inflammation,improve pulmonary ventilation function,reduce the radioactive pneumonia and bone marrow suppression rates in patients with NSCLC by acetylcysteine effervescent tablets.
    Effect of ultrasoundguided quadratus lumborum block on postoperative analgesia in parturient woman undergoing caesarean delivery
    ZHANG Longsheng, LIN Xulin, ZHANG Huankai, YANG Duo, LIN Gengbin, HUANG Zhiliang
    2018, 38(9):  1053-1057.  doi:10.3969/j.issn.10073205.2018.09.014
    Asbtract ( 540 )   PDF (392KB) ( 223 )  
    Related Articles | Metrics
    ［Abstract］ Objective〖HTSS〗〓To investigate the effect of ultrasoundguided quadratus lumborum block(QLB) on the efficacy postoperative analgesia in parturient woman undergoing caesarean delivery.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓There were 60 parturient in this study who were underwent full term cesarean section. Parturient woman were randomly divided into two groups:QLB group(Q group, n=30) and control group(C group, n=30).Two groups were treated by combined spinal epidural anesthesia, and all parturient woman were treated with PCIA after operation.After cesarean delivery,bilateral of ultrasoundguided QLB were performed,30 ml of 0.25% ropivacaine was injected in each side in Q group, while QLB was not done in C group. The time of operation, the amount of fluid infusion, the amount of bleeding and the volume of urine were recorded. The scores of resting and exercise VAS were recorded at 2, 4, 8, 12, 24, 36 and 48 h after operation.The time of the first press analgesia pump, the number of successfully doses(D1) and the number of attempts(D2) within 48 h, the amount of sufentanil within 48 h were recorded. D1/D2 was calculated. Postoperative recovery was recorded. The satisfaction of the parturient woman on the analgesic effect and the adverse reaction during the analgesia period were recorded at 48 hr postoperatively.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The VAS scores of the two groups at each time point were gradually rising and then decreasing, and the Q group was lower than the C group. The differences between intergroup, time point and interaction of intergroup and time point of two groups had the statistically significant. The first exhaust time,the time to eat ordinary food and the time to get out of bed after the operation were significantly lower,while the time of the first press analgesia pump, the value of D1/D2, the degree of satisfaction with analgesia were significantly higher in the Q group than those in C group(P＜005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓After cesarean section, the effect of ultrasoundguided QLB analgesia is accurate, which can significantly alleviate the postoperative pain, reduce the use of opioids, promote rapid recovery of maternal and improve satisfaction.
    The clinical value of pellet agglutination assay for MP antibody titer and colloidal gold method for simultaneously detection of MPIgM and MPIgG in children with mycoplasma pneumonia#br#
    ZHANG Wenchao1, ZHAO Mengchuan2, FENG Zhishan1, LI Mei1, GUO Yinghui1, LI Guixia1*
    2018, 38(9):  1058-1061,1066.  doi:10.3969/j.issn.10073205.2018.09.015
    Asbtract ( 660 )   PDF (401KB) ( 279 )  
    Related Articles | Metrics
    ［Abstract］〓Objective〖HTSS〗〓To explore the clinical diagnosis value of colloidal gold method for simultaneously detection of MPIgM and MPIgG in children with mycoplasma pneumoniae(MP) infection. 
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 344 suspected patients with MP infection were studied. MP antibody titer was detected by pellet agglutination assay, and MPIgM and MPIgG were simultaneously detected by colloidal gold method. Consistency of the results tested by the two methods was compared.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓When the antibody titers of 1〖DK〗∶160 were considered as positive by pellet agglutination assay, 233(67.7%) cases were negative for MP and 111(32.3%) cases were positive for MP. The results tested by diagnostic kit for IgM antibody to MP and diagnostic kit for IgG antibody to MP were roughly consistent with diagnostic kit for IgM and IgG antibody to MP. Using the results of clinical diagnosis as the gold standard, the sensitivity and negative predictive value of pellet agglutination assay were 100.0% when the critical value at the antibody titers of 1〖DK〗∶40, which was accordant with those of pellet agglutination assay when the critical value at the antibody titers of 1〖DK〗∶160. However, the specific, positive predictive value and accuracy of pellet agglutination assay when the critical value at the antibody titers of 1〖DK〗∶40 were significantly lower than those of pellet agglutination assay when the critical value at the antibody titers of 1〖DK〗∶160. The sensitivity, specific, positive predictive value, negative predictive value and accuracy difference between MPIgM, MPIgG and pellet agglutination assay when the critical value at the antibody titers of 1〖DK〗∶160 were basically identical.
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Colloidal gold method can simultaneously detect MPIgM and MPIgG of clinical suspected with MP infection, thus improving disease diagnosis rate, shortening the course of the disease, avoiding crossing infection and reducing the financial burden on patients and society.
    Application of quality control circles in redaucing the leakage rate of finished product in pharmacy intravenous admixture service#br#
    LIU Jian, WANG Mengyuan, JIN Yiran, YANG Xiuling*
    2018, 38(9):  1062-1066.  doi:10.3969/j.issn.10073205.2018.09.016
    Asbtract ( 803 )   PDF (575KB) ( 568 )  
    Related Articles | Metrics
    ［Abstract］ Objective〖HTSS〗〓To reduce the leakage rate of finished product in pharmacy intravenous admixture service, the risk caused by the leakage quality defects.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Using the quality control circle(QCC), the causes and types of the leakage were calculated and analyzed, formulate improvement was measured and put them into effect. Then the amount of leakage were calculated which occurred before and after the improvement in the proportion of the total amount to confirm effect.Reasonable measures should be brought into the standardized management, and at the same time we also review and improve the defective activity.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The leakage reason is mainly due to product process, cut bag and fold wear. After the improvement of any methods such as infusion placing, admixing and sorting, the leakage rate is reduced from 2.05×10-4 to 1.01×10-4. At the same time,we also get other aspects including the unnecessary waste of drugs, cost and working hours.
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Using the QCC management tools can save time and economic cost and improve the safety of medication.
    Analysis of adverse drug reaction reports of 479 cases in our hospital#br#
    HAN Yazhu1, LU Yi2, WANG Lu1, WU Lixin1, GENG Zhihui1*
    2018, 38(9):  1067-1070.  doi:10.3969/j.issn.10073205.2018.09.017
    Asbtract ( 437 )   PDF (387KB) ( 145 )  
    Related Articles | Metrics
    ［Abstract］ Objective〖HTSS〗〓To analyze and discuss the adverse drug reactions（ADR） in Baoding No.1 central hospital and refer to the clinical medication safety.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 479 cases of ADR reports were selected retrospectively. The patient′s gender, prognoses, route of administration, drug categories, ADR involving the organs or systems, and clinical manifestations were analyzed descriptively.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓In the 479 cases of ADR, the number of ADR caused by intravenous infusion was up to 307 cases, accounting for 64.1%. The most common cause of skin damage was 158 cases. The ADR caused by antiinfective drugs with 110 cases were the most, of which quinolones with 39 cases topped the list.
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓We should strengthen and attach importance to the adverse drug reaction in order to guarantee the public to use drug safely and reasonably.