定量冠状动脉CT血管成像参数与外周血血小板功能指标相关性及对冠状动脉狭窄的诊断价值

doi:10.3969/j.issn.1007-3205.2021.05.016

河北医科大学学报 ›› 2021, Vol. 42 ›› Issue (5): 575-581.doi: 10.3969/j.issn.1007-3205.2021.05.016

定量冠状动脉CT血管成像参数与外周血血小板功能指标相关性及对冠状动脉狭窄的诊断价值

1.安徽省太和县中医院CT室，安徽阜阳 236600;2.安徽省阜阳市第二人民医院CT室，安徽阜阳 236600

出版日期:2021-05-25 发布日期:2021-05-28
作者简介:田建（1983-），男，安徽临泉人，安徽省太和县中医院主治医师，医学学士，从事定量冠状动脉CT血管成像诊断研究。
基金资助:
安徽省科技攻关项目(1701042219)

Correlation between parameters of quantitative coronary CT angiography and platelet function indexes in peripheral blood and their diagnostic value for coronary artery stenosis

1.Department of CT Room, Taihe County Hospital of Traditional Chinese Medicine, Anhui Province,
Fuyang 236600, China; 2.Department of CT Room, the Second People′s Hospital of Fuyang City,
Anhui Province, Fuyang 236600, China

Online:2021-05-25 Published:2021-05-28

摘要/Abstract

摘要： 目的探究定量冠状动脉CT血管成像（computed tomography angiography，CTA）参数与外周血血小板功能指标相关性，并分析其对冠状动脉狭窄的诊断价值及病情程度的关系。
方法选取疑似冠状动脉狭窄患者183例作为研究对象，根据冠状动脉造影结果确诊为冠状动脉狭窄（125例）作为观察组，无冠状动脉狭窄（58例）作为对照组，比较两组及观察组不同病情患者定量冠状动脉CTA参数［最小管腔直径（minimal lumen diameter，MLD）、狭窄面积百分比（percentage of stenosis，%AS）、狭窄直径百分比（percentage of stenosis diameter，%DS）、最小管腔面积（minimal lumen area，MLA）］，并对比观察组不同病情患者外周血血小板功能指标［血小板平均体积（mean platelet volume，MPV）、血栓最大坚固度（thrombelastography maximum，TEG-MA）、血小板衍生生长因子BB（platelet derived growth factor-BB，PDGF-BB）］，分析定量冠状动脉CTA参数与外周血血小板功能指标相关性及对冠状动脉狭窄的诊断价值。
结果观察组MLA、MLD小于对照组，%AS、%DS大于对照组（P＜0.05）。MLA、MLD与狭窄程度呈负相关，与斑块性质呈正相关，%AS、%DS与狭窄程度呈正相关，与斑块性质呈负相关，MPV、TEG-MA、PDGF-BB与狭窄程度呈正相关，与斑块性质呈负相关（P＜0.05）。MLA、MLD与MPV、TEG-MA、PDGF-BB呈负相关，%AS、%DS与MPV、TEG-MA、PDGF-BB呈正相关（P＜0.05）。MLA联合MLD诊断冠状动脉狭窄曲线下面积为0.901，敏感度为76.80%，特异度为94.83%。
结论 CTA参数与外周血血小板功能存在一定相关性，采用定量冠状动脉CTA检查有助于提高冠状动脉狭窄诊断价值，评估冠状动脉粥样斑块性质，同时可作为评估病情严重程度的可靠无创手段。

关键词: 冠状动脉狭窄, 心血管造影术, 血小板

Abstract: Objective To explore the correlation between quantitative coronary computed tomography angiography(CTA) parameters and peripheral blood platelet function indexes, and to analyze its diagnostic value in coronary artery stenosis and its relationship with disease severity.
Methods A total of 183 patients with suspected CAS were selected as the research subjects. According to the results of coronary CTA, patients with confirmed CAS were enrolled as the observation group(n=125), and those without CAS were enrolled as the control group(n=58). The parameters of quantitative coronary CTA［minimum lumen diameter(MLD), percentage of area stenosis(%AS), percentage of diameter stenosis(%DS), minimum lumen area(MLA)］ between two groups and the observation group of patients with different conditions were compared. The platelet function indexes in peripheral blood of patients with different conditions in the observation group［mean platelet volume(MPV), thrombelastography maximum(TEG-MA), platelet-derived growth factor BB(PDGF-BB)］ were compared. The correlation between parameters of quantitative coronary CTA and platelet function indexes in peripheral blood and their diagnostic value for CAS were analyzed.
Results MLA and MLD in the observation group were smaller than those in the control group, and %AS and %DS were larger than those in the control group(P＜0.05). MLA and MLD were negatively correlated with the degree of stenosis and positively correlated with the plaque properties. %AS, %DS were positively correlated with the degree of stenosis and negatively correlated with the plaque properties. MPV, TEG-MA and PDGF-BB were positively correlated with the degree of stenosis and negatively correlated with the plaque properties(P＜0.05). MLA and MLD were negatively correlated with MPV, TEG-MA and PDGF-BB, and %AS and %DS were positively correlated with MPV, TEG-MA and PDGF-BB(P＜0.05). The area under the curve(AUC) of MLA and MLD in the diagnosis of CAS was 0.901, the sensitivity was 76.80%, and the specificity was 94.83%.
Conclusion There is a certain correlation between CTA parameters and peripheral blood platelet function. Quantitative coronary CTA examination can help improve the diagnostic value in coronary artery stenosis, and assess the properties of coronary atherosclerotic plaque, which can be used as a reliable non-invasive means to assess and judge the severity of the disease.

Key words: coronary stenosis, angiocardiography, platelets

田建, 刘军. 定量冠状动脉CT血管成像参数与外周血血小板功能指标相关性及对冠状动脉狭窄的诊断价值[J]. 河北医科大学学报, 2021, 42(5): 575-581.

TIAN Jian, LIU Jun. Correlation between parameters of quantitative coronary CT angiography and platelet function indexes in peripheral blood and their diagnostic value for coronary artery stenosis[J]. Journal of Hebei Medical University, 2021, 42(5): 575-581.

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定量冠状动脉CT血管成像参数与外周血血小板功能指标相关性及对冠状动脉狭窄的诊断价值

Correlation between parameters of quantitative coronary CT angiography and platelet function indexes in peripheral blood and their diagnostic value for coronary artery stenosis

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