河北医科大学学报 ›› 2021, Vol. 42 ›› Issue (7): 807-812.doi: 10.3969/j.issn.1007-3205.2021.07.013

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葡萄胎组织中ING4蛋白表达及与微血管密度的关系

  

  1. 1.河北生殖妇产医院妇科，河北 石家庄 050090；2.河北医科大学第三医院妇科，河北 石家庄 050051
  • 出版日期:2021-07-25 发布日期:2021-08-02
  • 作者简介:徐小燕（1973-），女，江苏沐阳人，河北生殖妇产医院主治医师，医学硕士，从事妇科肿瘤诊治研究。
  • 基金资助:
    河北省医学科学研究课题计划（20211622）

Expression of ING4 protein in hydatidiform mole and its relationship with microvessel density

  1. 1.Department of Gynaecology, Hebei Maternity Hospital, Shijiazhuang 050090, China; 
    2.Department of Gynaecology， the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
  • Online:2021-07-25 Published:2021-08-02

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摘要： 目的 探讨葡萄胎组织中生长抑制因子4（inhibitor of growth family member 4，ING4）蛋白表达与微血管密度（microvessel density，MVD）的关系与临床意义。
方法 采用免疫组织化学PV法检测葡萄胎组织及正常早孕绒毛组织中ING4蛋白表达及MVD。分葡萄胎组30例和正常早孕绒毛组20例。
结果 葡萄胎组ING4蛋白表达低于正常早孕绒毛组，完全性葡萄胎（complete hydatidiform mole，CHM）组和部分性葡萄胎（partial hydatidiform mole,PHM）组中ING4蛋白表达均低于正常早孕绒毛组（P＜0.05）。CHM组和PHM组的ING4蛋白表达差异无统计学意义(P＞0.05)。无高危因素组与有高危因素组ING4蛋白表达均低于正常早孕绒毛组（P＜0.05）。无高危因素与有高危因素组ING4蛋白表达差异无统计学意义(P＞0.05)。单因素分析结果表明，葡萄胎组织中ING4蛋白表达与临床高危因素无关（P＞0.05)。正常早孕绒毛组MVD值高于葡萄胎组MVD值，PHM组和CHM组MVD值均低于正常绒毛组，PHM组高于CHM组(P＜0.05)。无高危因素组和有高危因素组MVD值均小于正常绒毛组，有高危因素组高于无高危因素组(P＜0.05)。单因素分析结果表明，葡萄胎组织中MVD值与临床高危因素无关（P＞0.05)。葡萄胎组织中ING4蛋白表达与MVD无明显相关关系（r=0.137，P=0.470)。
结论 ING4蛋白的异位表达及降低促进葡萄胎的发生，ING4蛋白表达与临床高危因素无关，葡萄胎组织中血管缺失参与葡萄胎的发生，与临床高危因素无关，葡萄胎组织中ING4蛋白表达与MVD无明显相关性。


关键词: ING4蛋白, 微血管密度, 葡萄胎

Abstract: Objective To explore the relationship between expression of inhibitor of growth family member 4（ING4） protein and microvessel density in hydatidiform mole(HM) and the clinical significance. 
Methods Immunohistochemistry(PV method) was performed to detect the expression of the ING4 protein and microvessel density in HM tissue and the tissues of chorionic villi of normal early pregnancy. They were divided into hydatidiform mole group(n=30) and chorionic villi of normal early pregnancy group(n=20). 
Results The expression of ING4 protein was lower in HM group than in chorionic villi of normal early pregnancy group, and significantly lower in complete hydatidiform mole(CHM) group and partial hydatidiform mole(PHM) group than in chorionic villi of normal early pregnancy group(P＜0.05). There was no significant difference in ING4 protein expression between CHM group and PHM group(P＞0.05). The expression of ING4 protein in the groups with and without high-risk factors was lower than that in the chorionic villi of normal early pregnancy group(P＜0.05). There was no significant difference in ING4 protein expression between the groups without high-risk factors and those with high-risk factors(P＞0.05). The results of univariate analysis showed that the expression of ING4 protein in HM tissue was not related to clinical high-risk factors(P＞0.05). The MVD value of the chorionic villi of normal early pregnancy group was higher than that of the HM group, and lower in the PHM group and the CHM group than in chorionic villi of normal early pregnancy group, and the value in the PHM group was higher than that of the CHM group(P＜0.05). The MVD values of the groups with or without high-risk factors were lower than those in chorionic villi of normal early pregnancy group, and the value in the group with high-risk factors was higher than that of the group without high-risk factors(P＜0.05). The results of univariate analysis showed that the MVD value in HM tissue was not associated with clinical high-risk factors(P＞0.05). The expression of ING4 protein in HM tissue was not correlated with MVD(r=0.137, P=0.470). 
Conclusion The ectopic and downregulated expression of ING4 protein promotes the occurrence of HM. ING4 protein expression is not associated with clinical risk factors. The absence of blood vessels in HM tissue is involved in the development of HM, and is not related to clinical high-risk factors. ING4 protein expression in HM tissue has no significant correlation with MVD.


Key words: ING4 protein, microvessel density, hydatidiform mole

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