复方氟米松软膏治疗慢性泛发性湿疹的效果及其对血清炎症因子水平的影响

doi:10.3969/j.issn.1007-3205.2022.03.014

河北医科大学学报 ›› 2022, Vol. 43 ›› Issue (3): 316-319.doi: 10.3969/j.issn.1007-3205.2022.03.014

复方氟米松软膏治疗慢性泛发性湿疹的效果及其对血清炎症因子水平的影响

1.苏州大学附属常熟市第一人民医院皮肤科，江苏苏州 215500；2.江苏省无锡市锡山人民医院皮肤科，江苏无锡 214000

出版日期:2022-03-25 发布日期:2022-04-14
作者简介:薛峤（1987-），女，江苏常熟人，苏州大学附属常熟市第一人民医院主治医师,医学硕士，从事皮肤科疾病诊治研究。
基金资助:
江苏省无锡市卫生计生委科研项目（Q201716）

Efficacy of compound flumethasone ointment in the treatment of chronic generalized eczema and its effect on the level of serum inflammatory factors

1.Department of Dermatology, the First People′s Hospital of Changshu City Affiliated to Suzhou
University, Jiangsu Province, Suzhou 215500, China; 2.Department of Dermatology, Xishan People′s Hospital of Wuxi, Jiangsu Province, Wuxi 214000, China

Online:2022-03-25 Published:2022-04-14

摘要/Abstract

摘要：

目的探讨复方氟米松软膏治疗慢性泛发性湿疹的效果及对血清炎症因子水平的影响。

方法选取苏州大学附属常熟市第一人民医院收治的慢性泛发性湿疹患者（104例）为研究对象，以随机数字表法分成对照组（52例）和研究组（52例）。对照组采用丁酸氢化可的松软膏治疗，研究组采用复方氟米松软膏治疗。对比两组临床疗效、治疗前后血清炎症因子水平，统计两组药物安全性及停药后1个月的复发情况。

结果研究组总有效率高于对照组（P＜0.05）。两组治疗前血清白细胞介素4（interleukin-4，IL-4）、白细胞介素10（interleukin-10，IL-10）水平对比差异均无统计学意义（P＞0.05），两组治疗后的IL-4、IL-10水平较治疗前均降低（P＜0.05），治疗后研究组的IL-4、IL-10水平均低于对照组（P＜0.05）。两组药物总不良反应发生率差异无统计学意义（P＞0.05）。研究组复发率（13.46%）低于对照组（30.77%）（P＜0.05）。

结论采用复方氟米松软膏治疗慢性泛发性湿疹的效果确切，并可有效降低慢性泛发性湿疹患者血清炎症因子水平，减小复发风险，且安全性良好。

关键词:

湿疹, 氟米松, 治疗结果

Abstract:

Objective To explore the efficacy of compound flumethasone ointment in the treatment of chronic generalized eczema and its effect on the level of serum inflammatory factors.

Methods A total of 104 patients with chronic generalized eczema admitted to the First People′s Hospital of Changshu City Affiliated to Suzhou University were selected as the research subjects. They were divided into control group(n=52) and research group(n=52) by random number table method. The control group was treated with hydrocortisone butyrate ointment, and the research group was treated with compound flumethasone ointment. The clinical efficacy, and the level of serum inflammatory factors before and after treatment were compared between two groups. The safety of drugs in the two groups and the recurrence at 1 month after drug withdrawal were calculated.

Results The total effective rate was higher in research group than in control group(P＜0.05). There was no significant difference in the levels of serum interleukin-4(IL-4) and interleukin-10(IL-10) between two groups before treatment(P＞0.05). The levels of IL-4 and IL-10 after treatment in two groups were lower than those before treatment(P＜0.05), while the levels of IL-4 and IL-10 in the research group after treatment were lower than those in the control group(P＜0.05). There was no significant difference in the total incidence of adverse drug reactions between two groups(P＞0.05). The recurrence rate of the research group(13.46%) was lower than that(30.77%) of control group(P＜0.05).

Conclusion The compound flumethasone ointment has a definite effect in the treatment of chronic generalized eczema, which can effectively reduce the serum inflammatory factor level in patients with chronic generalized eczema, reduce the risk of recurrence, and has good safety.

Key words: eczema, flumethasone, treatment outcome

薛峤, 范文葛, 陈诚. 复方氟米松软膏治疗慢性泛发性湿疹的效果及其对血清炎症因子水平的影响[J]. 河北医科大学学报, 2022, 43(3): 316-319.

XUE Qiao, FAN Wen-ge, CHEN Cheng. Efficacy of compound flumethasone ointment in the treatment of chronic generalized eczema and its effect on the level of serum inflammatory factors[J]. Journal of Hebei Medical University, 2022, 43(3): 316-319.

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复方氟米松软膏治疗慢性泛发性湿疹的效果及其对血清炎症因子水平的影响

Efficacy of compound flumethasone ointment in the treatment of chronic generalized eczema and its effect on the level of serum inflammatory factors

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