河北医科大学学报 ›› 2022, Vol. 43 ›› Issue (5): 574-577.doi: 10.3969/j.issn.1007-3205.2022.05.015

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西替利嗪辅助沙丁胺醇对支气管哮喘急性发作患儿气道重塑、PDCD5、S1P水平的影响

  

  1. 1.山东省青岛市市立医院儿科，山东 青岛 266000;2.山东省青岛西海岸新区人民医院儿科，山东 青岛 266000
  • 出版日期:2022-05-25 发布日期:2022-05-30
  • 作者简介:田文朋（1984-），男，山东宁阳人，山东省青岛市市立医院主治医师，医学硕士，从事儿科疾病诊治研究。
  • 基金资助:

    山东省卫生厅指导性科研计划(SG2020423)

Effects of cetirizine combined with salbutamol on airway remodeling, PDCD5 and S1P levels in children with acute attack of bronchial asthma

  1. 1.Department of Pediatrics, Qingdao Municipal Hospital, Shandong Province, Qingdao 266000, China;

    2.Department of Pediatrics, the People′s Hospital of Qingdao West Coast New Area, Shandong Province, Qingdao 266000, China

  • Online:2022-05-25 Published:2022-05-30

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摘要：

目的  观察西替利嗪辅助沙丁胺醇对支气管哮喘急性发作患儿气道重塑、程序化死亡分子5（programmed death molecule 5，PDCD5）、1-磷酸鞘氨醇（sphingosine 1-phosphate，S1P）水平的影响。

方法  选择支气管哮喘急性发作患儿200例，按照随机数字表法分为对照组和研究组，每组100例。对照组患儿接受沙丁胺醇治疗，研究组患儿接受西替利嗪辅助沙丁胺醇治疗，均治疗7 d。比较2组患儿疗效和气道重塑［骨桥蛋白（osteopontin，OPN)、血管内皮生长因子（vascular endothelial growth factor，VEGF）、基质金属蛋白9（matrix metalloproteinase-9，MMP-9）、基质金属蛋白水解酶组织抑制因子1（tissue inhibitor of metalloproteinase-1，TIMP-1）］、PDCD5、S1P水平变化情况。观察2组治疗期间不良反应发生率。

结果  治疗7 d后，研究组患儿临床总有效率高于对照组（P＜0.05）。治疗7 d后，2组患儿OPN、VEGF、MMP-9、TIMP-1、PDCD5、S1P水平低于治疗前，研究组OPN、VEGF、MMP-9、TIMP-1、PDCD5、S1P水平低于对照组（P＜0.05）。2组不良反应发生率差异无统计学意义（P＞0.05）。

结论  西替利嗪辅助沙丁胺醇治疗支气管哮喘急性发作患儿，可有效抑制患儿气道重塑，降低PDCD5、S1P水平，是一种安全可靠的治疗方案。

关键词:

哮喘, 西替利嗪；沙丁胺醇

Abstract:

Objective  To observe the effects of cetirizine combined with salbutamol on airway remodeling, programmed death molecule 5(PDCD5) and sphingosine 1-phosphate(S1P) levels in children with acute attack of bronchial asthma.

Methods  In total,200 children with acute attack of bronchial asthma were selected and randomly divided into control group(n=100) and research group(n=100). The children in the control group were treated with salbutamol, and the children in the research group were treated with cetirizine-assisted salbutamol. Both groups were treated for 7 d. The curative effect and the changes in airway remodeling［osteopontin(OPN), vascular endothelial growth factor(VEGF), matrix metalloproteinase-9(MMP-9), tissue inhibitor of metalloproteinase-1(TIMP-1)］, PDCD5 and S1P levels were compared between two groups. The incidence of adverse reactions during treatment was observed in both groups.

Results  At 7 d after treatment, the total effective rate of the research group was higher than that of the control group(P＜0.05). At 7 d after treatment, the levels of OPN, VEGF, MMP-9, TIMP-1, PDCD5 and S1P in the two groups were lower than those before treatment, while the levels of OPN, VEGF, MMP-9, TIMP-1, PDCD5 and S1P in the research group were lower than those in the control group(P＜0.05). There was no significant difference in the incidence of adverse reactions between two groups(P＞0.05).

Conclusion  Cetirizine combined with salbutamol in the treatment of children with acute attack of bronchial asthma can effectively inhibit airway remodeling and reduce the levels of PDCD5 and S1P. It is a safe and reliable treatment scheme.

Key words: asthma; cetirizine, salbutamol

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