河北医科大学学报 ›› 2022, Vol. 43 ›› Issue (12): 1445-1448.doi: 10.3969/j.issn.1007-3205.2022.12.015

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VEGF基因多态性在多囊卵巢综合征中的表达及意义

  

  1. 1.河北医科大学第四医院肿瘤研究所分子生物学研究室，河北 石家庄 050011；
    2.河北医科大学第四医院生殖医学科，河北 石家庄 050011

  • 出版日期:2022-12-25 发布日期:2023-01-11
  • 作者简介:黄茜（1984-），女，河北石家庄人，河北医科大学第四医院肿瘤研究所助理研究员，理学博士，从事多囊卵巢综合征发病机制研究。
  • 基金资助:
    河北省医学科学研究重点课题计划（20180559）

Expression and significance of vascular endothelial growth factor gene polymorphism in polycystic ovary syndrome

  1. 1.Department of Molecular Biology, Cancer Institute of the Fourth Hospital of Hebei Medical University, 
    Shijiazhuang 050011, China; 2.Department of Reproductive Medicine, the Fourth 
    Hospital of Hebei Medical University, Shijiazhuang 050011, China
  • Online:2022-12-25 Published:2023-01-11

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摘要： 目的 探讨血管内皮生长因子基因（vascular endothelial growth factor gene,VEGF）rs699947和rs1570360的单核苷酸多态性（single nucleotide polymorphism,SNP）与多囊卵巢综合征（polycystic ovary syndrome,PCOS）发病风险之间的关系。
方法 运用了聚合酶链反应-连接酶检测反应（polymerase chain reaction-ligase detection reaction,PCR-LDR）的方法共分析PCOS患者152例和健康对照者160例VEGF基因rs699947和rs1570360 的单核苷酸多态性和PCOS发病风险之间的关联。
结果 与AA基因型相比，携带CC基因型可能增加了PCOS的发病风险，控制了年龄和肥胖家族史等因素后的OR值为2.896（95%CI=1.388~6.043）。
结论 VEGF基因rs699947增加了北方妇女对PCOS的遗传易感性，携带CC基因型增加了PCOS的发病风险。


关键词: 多囊卵巢综合征, VEGF基因, 单核苷酸多态性

Abstract: Objective To explore the association of single nucleotide polymorphism (SNP)of vascular endothelial growth factor (VEGF) gene rs699947 and rs1570360 SNP with risk of polycystic ovary syndrome (PCOS). 
Methods The association of SNP of VEGF gene rs699947 SNP and rs1570360 SNP with risk of PCOS in 152 PCOS patients and 160 healthy controls was analyzed by polymerase chain reaction-ligase detection reaction (PCR-LDR) method . 
Results The women carrying CC genotype had a higher risk of PCOS compared with the women with the AA genotype. After adjustment of factors, such as age and family history of obesity, OR was 2.896 (95%CI=1.388-6.043). 
Conclusion VEGF gene rs699947 SNP increases the genetic susceptibility of women to PCOS in north China, and the women carrying the CC genotype have a higher risk of PCOS. 


Key words: polycystic ovary syndrome, vascular endothelial growth factor gene, single nucleotide polymorphism

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