变应性鼻炎患者nFeNO、OPN、sIgE表达及对合并哮喘的辅助诊断价值

doi:10.3969/j.issn.1007-3205.2023.06.015

河北医科大学学报 ›› 2023, Vol. 44 ›› Issue (6): 697-701.doi: 10.3969/j.issn.1007-3205.2023.06.015

变应性鼻炎患者nFeNO、OPN、sIgE表达及对合并哮喘的辅助诊断价值

1.海南省儋州市人民医院耳鼻喉科,海南儋州 571799;2.海南西部中心医院耳鼻咽喉头颈外科,海南儋州 571799

出版日期:2023-06-25 发布日期:2023-06-29
作者简介:李君（1989-），男，海南儋州人，海南省儋州市人民医院主治医师，医学学士，从事鼻科疾病诊治研究。
基金资助:
海南省卫生计生行业科研项目(2001320114A2005)

Expression of nFeNO, OPN and sIgE in AR patients and their value in auxiliary diagnosis of asthma

1.Department of Otolaryngology, Danzhou People′s Hospital, Hainan Province, Danzhou
571799, China; 2.Department of Otolaryngology Head and Neck Surgery,
Hainan West Central Hospital, Danzhou 571799, China

Online:2023-06-25 Published:2023-06-29

摘要/Abstract

摘要： 目的探讨变应性鼻炎（allergic rhinitis，AR）患者鼻呼出气一氧化氮（nasal fractional exhaled nitric oxide，nFeNO）、骨桥蛋白（osteopontin，OPN）、特异性IgE（specific immunoglobulin E，sIgE）表达情况及对合并哮喘的辅助诊断价值。
方法选取AR患者228例为观察组，其中单纯AR 187例，AR合并哮喘41例；同期选取45例健康体检者为对照组。比较两组nFeNO、OPN、sIgE水平，分析AR患者nFeNO、OPN、sIgE水平与鼻部症状总评分（Total Nasal Symptom Score，TNSS）评分相关性，Logistic回归分析AR合并哮喘的独立影响因素，受试者工作特征（receiver operating characteristic，ROC）曲线分析nFeNO、OPN、sIgE对AR合并哮喘的诊断价值。
结果观察组nFeNO、OPN、sIgE水平高于对照组（P＜0.05）；AR患者nFeNO、OPN、sIgE水平与TNSS评分呈正相关（P＜0.05）；Logistic回归分析显示，nFeNO、OPN、sIgE水平升高均为AR合并哮喘的独立危险因素（P＜0.05）；ROC曲线显示，nFeNO、OPN、sIgE联合诊断AR合并哮喘的AUC值为0.829，高于单独诊断。
结论 AR患者nFeNO、OPN、sIgE水平与TNSS评分呈正相关，且AR合并哮喘具有良好预测和辅助诊断作用。

关键词: 鼻炎, 变应性, 季节性, 一氧化氮, 哮喘

Abstract: Objective To investigate the expressions of nasal fractional exhaled nitric oxide (nFeNO), osteopontin (OPN) and specific immunoglobulin E (sIgE) in patients with allergic rhinitis (AR) and their value in auxiliary diagnosis of asthma.
Methods A total of 228 AR patients in our hospital were selected as the observation group, including 187 patients with pure AR and 41 patients with AR combined with asthma; 45 healthy people undergoing physical examination during the same period were selected as the control group. The levels of nFeNO, OPN, and sIgE between two groups were compared, and the correlation between the levels of nFeNO, OPN, and sIgE in AR patients and total nasal symptom score (TNSS) score was analyzed. Logistic regression analysis was used to analyze the independent influencing factors of AR with asthma, and receiver operating characteristic (ROC) curve analysis was used to analyze the diagnostic value of nFeNO, OPN and sIgE for AR complicated with asthma.
Results The levels of nFeNO, OPN and sIgE in the observation group were higher than those in the control group (P＜0.05). The levels of nFeNO, OPN and sIgE in AR patients were positively correlated with the TNSS score (P＜0.05). Logistic regression analysis showed that the increased levels of nFeNO, OPN and sIgE were independent risk factors for AR complicated with asthma (P＜0.05). The ROC curve showed that the AUC value of nFeNO, OPN and sIgE in combination to diagnose AR complicated with asthma was 0.829, which was higher than that of single indicator in diagnosis.
Conclusion The levels of nFeNO, OPN and sIgE in AR patients are positively correlated with the TNSS score, and are of great value in prediction and auxiliary diagnosis of AR complicated with asthma.

Key words: rhinitis, allergic, seasonal, nitric oxide, asthma

李君, 叶方, 韩富光, 李波. 变应性鼻炎患者nFeNO、OPN、sIgE表达及对合并哮喘的辅助诊断价值 [J]. 河北医科大学学报, 2023, 44(6): 697-701.

LI Jun, YE Fang, HAN Fu-guang, LI Bo. Expression of nFeNO, OPN and sIgE in AR patients and their value in auxiliary diagnosis of asthma[J]. Journal of Hebei Medical University, 2023, 44(6): 697-701.

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变应性鼻炎患者nFeNO、OPN、sIgE表达及对合并哮喘的辅助诊断价值

Expression of nFeNO, OPN and sIgE in AR patients and their value in auxiliary diagnosis of asthma

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