河北医科大学学报

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冠心病介入诊治大剂量碘负荷对甲状腺功能及形态的近期影响

  

  1. 河北医科大学第二医院东院区心内一科,河北 石家庄 050035
  • 出版日期:2016-04-25 发布日期:2016-05-18
  • 作者简介:王亚玲( 1981- ),女,河北卢龙人,河北医科大学第 二医院主治医师,医学硕士,从事心血管疾病诊治研究。
  • 基金资助:
    河北省医学科学研究重点课题( ZL20140139 )

Short-termeffectoflargedosageiodinecontrastonthyroidfunctionand morphologyindiagnosisandtreatmentofcoronaryheartdisease

  1. (Department of Cardiology Ⅰ, the East Branch of Second Hospital of Hebei Medical University, Shijiazhuang 050035, China
  • Online:2016-04-25 Published:2016-05-18

摘要: [摘要] 目的 观察冠心病介入诊治过程中大剂量碘对比剂对甲状腺功能及形态的近期影响。方法 将甲状
腺功能正常的冠心病患者分为 2 组,冠状动脉造影 50 例为小剂量造影组,经皮冠状动脉介入治疗(
percutaneous
coronaryintervention , PCI ) 50 例为大剂量 PCI 组,分别于术前、术后 2 周测定游离三碘甲状腺原氨酸( freetri-
iodothyronine , FT 3 )、游离甲状腺素( freethyroxine , FT 4 )、三碘甲状腺原氨酸总量( totaltri-iodothyronine , TT 3 )、甲
状腺素总量(
totalthyroxine , TT 4 )、促甲状腺激素( thyroid-stimulatinghormone , TSH )、甲状腺过氧化物酶( thyroid
peroxidase , TPO )抗体、甲状腺球蛋白抗体(
thyroglobulinantibody , TGAB )、甲状腺刺激抗体( thyroidstimulating
antibody , TSAB )及甲状腺超声。结果 术后 2 周 2 组
TSH 及 FT 3 浓度较术前有所变化,差异均有统计学意义
( P <0.05 ),但 2 组间差异无统计学意义( P >0.05 )。术后 2 周 2 组 FT 4 、 TT 3 、 TT 4 、 TPO 、 TSAB 、 TGAB 与术前差
异均无统计学意义( P >0.05 ),
2 组间差异亦无统计学意义( P >0.05 )。 2 组术前及术后 2 周甲状腺形态均无明显
改变。结论 冠心病介入诊治过程中大剂量碘对比剂对甲状腺功能近期存在亚临床甲状腺功能亢进的风险,近期
对甲状腺形态无明显影响。

关键词: 冠心病, 冠状血管造影术, 造影剂, 甲状腺

Abstract: [
Abstract ] Objective Toobserveshort-termeffectoflargedosageiodinecontrastonthyroid
functionandmorphologyindiagnosisandtreatmentofcoronaryheartdisease.Methods Fifty
patientswith normalthyroidfunction underwentcoronaryangiography.Fifty patients with
normalthyroidfunction underwentpercutaneouscoronaryintervention .Thebloodfreetri-
iodothyronine ( FT 3 ), freethyroxine ( FT 4 ), totaltri-iodothyronine ( TT 3 ), totalthyroxine ( TT 4 ),
thyroid-stimulating hormone ( TSH ), thyroid peroxidase ( TPO ), thyro globulin antibody
( TGAB ), thyroidstimulatingantibody ( TSAB ) weremeasuredandthyroid morphologywere
measuredbyultrasonographybeforeangiographyandtwoweeksafterthetherapy.Results
ThereweresignificantchangesofTSHandFT 3 comparedwithbeforetherapyaftertwoweeks
(
P <0.05 ) .Buttherewasnosignificantchangebetweentwoguoups.Therewerenosignificant
changesofFT 4 , TT 3 , TT 4 , TPO , TSAB , TGABafterthe2 weekscompared withbefore
therapy ( P >0.05 ) .Andtherewasnochangebetweentwogroups.Therewasnoobviouschange onthyroidmorphologymeasuredbyultrasonographyafter2weeks.Conclusion Therehasrisk
ofsubclinicalthyroidfunctionhyperfunctionwithlargedosageiodinecontrastindiagnosisand
treatmentofcoronary heartdiseaseinthenearfuture.Therehasnoinfluenceonthyroid
morphologywithlargedosageiodinecontrastindiagnosisandtreatmentofcoronaryheartdisease
inthenearfuture.

Key words: coronary heart disease, coronary angiography, contrast media, thyroid gland