河北医科大学学报

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双侧标准外伤大骨瓣减压术配合亚低温冬眠疗法救治急性外伤性脑肿胀

  

  1. 海南省三亚市人民医院神经外科,海南 三亚 572000
  • 出版日期:2016-04-25 发布日期:2016-05-18
  • 作者简介:陈鸿尤( 1971- ),男,海南三亚人,海南省三亚市人 民医院副主任医师,医学学士,从事神经外科疾病诊治研究。
  • 基金资助:
    三亚市医疗卫生科技创新项目( 2014YW10 )

Bilateral standard large trauma craniotomy combined with mild hypothermia hibernation therapy for acute traumatic brain swelling

  1. Department of Neurosurgery, Sanya People′s hospital, Sanya, 572000, China
  • Online:2016-04-25 Published:2016-05-18

摘要: [摘要] 目的 探讨双侧标准外伤大骨瓣减压术配合亚低温冬眠疗法在急性外伤性脑肿胀治疗中的效果。方
法 选取急性外伤性脑肿胀患者 112 例,试验组 68 例应取双侧标准外伤大骨瓣减压术配合亚低温冬眠疗法,对照
组 44 例应用常规去骨瓣减压术及常规治疗,观察并记录 2 组临床疗效。结果 试验组临床疗效明显优于对照组,
差异有统计学意义(
Uc =3.839 , P =0.001 )。试验组治疗有效率( 67.6% )明显高于对照组效率( 27.3% ),差异有统
计学意义( P <0.01 )。结论 双侧标准外伤大骨瓣减压术配合亚低温冬眠疗法治疗急性外伤性脑肿胀效果显著,预
后较常规治疗好。

关键词: 脑损伤, 脑水肿, 减压颅骨切除术, 冬眠

Abstract: [
Abstract ] Objective Toinvestigatetheeffectofbilateralstandardlargetraumacraniotomy
combinedwithmildhypothermiahibernationtherapyinthetreatmentofacutetraumaticbrain
swelling.Methods Onehundred-twelvecasesofpatientswithacutetraumaticbrainswelling
werechosentobeobservedandrecordedtheprognosis.Amongthem , 68casesasexperimental
groupweretookbilateralstandardlargetraumacraniectomycoupled with mildhypothermia
therapy , 44casesascontrolgroupweretreatedwithconventionaldecompressivecraniectomyand
routinetreatment.Results Theclinicalefficacyoftheexperimentalgroup wassignificantly
betterthanthatofthecontrolgroup , thedifferencewasstatisticallysignificant ( Uc =3.839 , P =
0.001 ) .Theeffectiverateoftheexperimentalgroupwas ( 67.6% ), significantlyhigherthanthat
ofthecontrolgroup ( 27.3% ), thedifferencewasstatisticallysignificant
(
P <0.01 ) .Conclusion
Theeffectsofbilateralstandardtraumalargeboneflapdecompressioncombined with mild
hypothermiahibernationtherapyforacutetraumaticbrainswellingwassignificant , theprognosis
isbetterthanconventionaltreatment

Key words: brain injuries; brain edema; decompressive craniectomy, hibernation