河北医科大学学报

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给药方式对替罗非班治疗急性心肌梗死患者PCI预后效果的影响

  

  1. 河北省石家庄市第一医院心内科,河北 石家庄 050011
  • 出版日期:2016-10-25 发布日期:2016-11-04
  • 作者简介:龚肖丽( 1981- ),女,河北晋州人,河北省石家庄市 第一医院主治医师,医学学士,从事心血管内科疾病诊治研究。

Effect of administration mode on the prognosis of PCI in patients with acute myocardial infarction

  1. Department of Cardology, the First Hospital of Shijiazhuang City, Hebei Province, Shijizhuang 050011, China
  • Online:2016-10-25 Published:2016-11-04

摘要: [摘要] 目的 探讨给药方式 对替 罗非 班 治疗 急性 心肌 梗 死患 者经 皮冠 状 动脉 介入 治 疗( percutaneous
coronaryintervention , PCI )预后效果的影响。方法 选取急性心肌梗死患者 200 例,随机分为 3 组,经静脉组 70 例、
经冠状动脉组 70 例和对照组 60 例。经静脉组经静脉注射 10 μ g /
kg
负荷量替罗非班,经冠状动脉组给予 10 μ g /
kg
负荷量替罗非班,对照组给予常规治疗。结果 经静脉组、经冠状动脉组 PCI 术后心肌梗死溶栓治疗血流分级更偏
向于分级高的 2 级和 3 级,与对照组差异有统计学意义( P <0.05 ); 3 组病死率差异无统计学意义( P >0.05 );经静
脉组和经冠状动脉组顽固性缺血、恶性心律失常、再次心肌梗死等主要不良心脏事件发生率均显著低于对照组
( P <0.05 ),左心室射血分数、舒张早期心室充盈速度最大值/舒张晚期心室充盈速度最大值比值 >1 的比例、出血
发生率均显著高于对照组( P <0.05 ),血小板计数均显著少于对照组(
P <0.05 )。结论 经静脉及经冠状动脉给予
负荷量替罗非班均能够有效改善急性心肌梗死患者 PCI 预后

关键词: 心肌梗死, 替罗非班, 给药方式, 预后

Abstract: [
Abstract ] Objective Toinvestigatetheeffectofcoronaryinterventionontheprognosisof
patientswithacutemyocardialinfarctiontreatedbypercutaneouscoronaryintervention ( PCI ) .
Methods Two hundredcasesofpatients with acute myocardialinfarction wererandomly
selected , whoweredividedintothreegroups , namelyintravenousgroup ( n =70 ), intracoronary
group ( n =70 ) andcontrolgroup ( n =60 ) .Theintravenousgroupweregivenintravenousbolus10
μ g
/ kgloadingdosetirofiban , theintracoronarygroupweregivencoronary10 μ g / kgloadingdose
tirofiban , thecontrolgroupweregivenconventionaltreatment.Results Thethrombolysisin
myocardialinfartionflow0 , 1 , 2ratiosafterPCIoftheintravenousgroup , coronarygroupwere
significantlylower ( P <0.05 ), the3ratiowassignificantlyhigher ( P <0.05 ) .Therewasno
significantdifferenceinmortalitybetweenthe3groups ( P >0.05 ) .Theincidencesofthedeath ,
refractoryischemia , malignantarrhythmia , againprimaryendpointofmyocardialinfarctionin
intravenousgroupandcoronaryarterygroupweresignificantlylowerthanthatinthecontrol
group ( P <0.05 ) .TheLeftventricularejectionfraction , E / A>1ratio , incidenceofbleeding
weresignificantlyhigher ( P <0.05 ), theplateletcountwassignificantlylessthanthatinthe
controlgroup ( P <0.05 ) .Conclusion Intravenousandintracoronaryloadingdoseoftirofibanare
abletoimprovethePCIprognosisofpatientswithacutemyocardialinfarction.

Key words: myocardialinfarction , tirofiban , administration , prognosis