河北医科大学学报

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难治性结核性脑膜炎的影响因素分析

  

  1. 1.河北省胸科医院神经内科,河北 石家庄 050041;2.河北省胸科医院妇产科,河北 石家庄 050041;
    3.河北省胸科医院医务处,河北 石家庄 050041;4.河北省石家庄市第五医院检验科,河北 石家庄 050024;
    5.河北省胸科医院影像科,河北 石家庄 050041
  • 出版日期:2017-04-25 发布日期:2017-04-25
  • 作者简介:陈颜强(1976-),男,河北元氏人,河北省胸科医院副主任医师,医学硕士,从事神经内科疾病诊治研究。
  • 基金资助:
    河北省医学科学研究重点课题(20150139)

Analysis of influencing factors of refractory tuberculous meningitis

  1. 1.Department of Neurology, the Chest Hospital of Hebei Province, Shijiazhuang 050041, China;
    2.Department of Obstetrics and Gynecology, the Chest Hospital of Hebei Province, Shijiazhuang
    050041, China; 3.Department of Medical, the Chest Hospital of Hebei Province, Shijiazhuang
    050041, China; 4.Department of Clinical Laboratory, the Fifth Hospital of Shijiazhuang City,
    Hebei Province, Shijiazhuang 050024, China; 5.Department of Medical Imaging, the
    Chest Hospital of Hebei Province, Shijiazhuang 050041, China
  • Online:2017-04-25 Published:2017-04-25

摘要: [摘要]〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨难治性结核性脑膜炎的影响因素。
〖HTH〗方法〖HTSS〗〖KG*2〗将99例结核性脑膜炎患者分为普通结核性脑膜炎组和难治性结核性脑膜炎组,对2组患者的临床特点、脑脊液指标、影像学分型、抗结核药物方案、激素应用、椎管注药等方面进行分析。
〖HTH〗结果〖HTSS〗〖KG*2〗难治组病程>3个月、院外抗结核药物、弱方案、脑膜强化比例高于普通组,初治强四化比例低于普通组,脑脊液白细胞数高于普通组,脑脊液氯、腺苷脱氨酶水平低于普通组(P<005)。Logistic回归分析结果显示,院前抗结核治疗、氯化物<120 mmol/L、治疗方案是结核性脑膜炎的影响因素。
〖HTH〗结论〖HTSS〗〖KG*2〗脑脊液低氯是难治性结核性脑膜炎的预测因素,抗结核方案的强弱对结核性脑膜炎预后有很大影响。

关键词: 结核, 脑膜, 影响因素分析, 治疗结果

Abstract: [Abstract]  Objective〖HTSS〗〓To investigate the influencing factors of refractory tuberculous meningitis.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Ninetynine patients with tuberculous meningitis were divided into ordinary tuberculous meningitis group and refractory tuberculous meningitis group. The clinical features, cerebrospinal fluid index, image credits, antituberculosis drugs, hormone application and vertebral canal injection medicin were analyzed of 2 groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Univariate analysis showed that disease progression(>3 months), applied antituberculosis drugs outside the hospital, difference of antituberculosis program, cerebrospinal fluid indicators(number of cells, chlorine value, adenosine deamianse), meninges strengthening in the 2 groups of patients were significantly different(P<005). The results of Logistic regression analysis showed that prehospital antituberculosis treatment and chloride<120 mmol/L, antituberculosis program were the influencing factors of tuberculous meningitis.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Low chlorine of cerebrospinal fluid is an independent predictor of refractory tuberculous meningitis, the strength of the chemotherapy scheme has a great influence on tuberculous meningitis.

Key words: tuberculosis, meningeal, root cause analysis, treatment outcome