河北医科大学学报

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白细胞介素28B基因多态性与慢性HCV感染及抗HCV疗效的关系

  

  1. 河北医科大学第三医院中西医结合肝病科，河北 石家庄 050051
  • 出版日期:2017-07-25 发布日期:2017-07-05
  • 作者简介:孔令波（1981-），女，河北临漳人，河北医科大学第三医院主治医师，医学博士，从事慢性肝病诊治研究。
  • 基金资助:
    河北省医学科学研究重点课题（20130227）；河北省科学技术研究与发展计划（10276102D）

Association between interleukin 28B gene polymorphisms and chronic hepatitis C virus infection and response to antiHCV treatment#br#

  1. Department of Traditional and Western Medical Hepatology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
  • Online:2017-07-25 Published:2017-07-05

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摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨白细胞介素28B（interleukin 28B，IL28B）基因单核苷酸多态性（single nucleotide polymorphisms，SNPs）与丙型肝炎病毒（hepatitis C virus，HCV）慢性感染及抗病毒疗效的关系。
〖HTH〗方法〖HTSS〗〖KG*2〗选择河北省慢性丙型肝炎及代偿期丙型肝炎肝硬化患者253例，健康体检者83例作为对照组。TaqMan探针法检测IL28B rs8099917位点SNPs，分析HCV感染患者与对照组IL28B rs8099917位点等位基因及基因型分布差异，并探讨患者IL28B rs8099917位点SNPs与抗HCV疗效的关系。
〖HTH〗结果〖HTSS〗〖KG*2〗患者IL28B rs8099917位点G、T等位基因分布以及GG/GT、TT基因型分布与对照组比较，差异无统计学意义（P＞005）。IL28B rs8099917位点SNPs与患者基线HCV RNA水平及HCV 基因型均不相关（P＞005）。获得完全早期病毒学应答（complete early virological response，cEVR）及持续病毒学应答（sustained virological response，SVR）的患者IL28B rs8099917位点T等位基因、TT基因型携带率均显著高于未获得cEVR及SVR患者。
〖HTH〗结论〖HTSS〗〖KG*2〗河北省人群IL28B rs8099917位点SNPs与HCV慢性感染易感性不相关，且与患者基线HCV RNA水平及感染HCV基因型不相关。携带TT基因型患者更易获得cEVR及SVR。

关键词: 丙型肝炎, 慢性, 白细胞介素28B, 多态性, 单核苷酸

Abstract: ［Abstract］ Objective〖HTSS〗〓To explore the association of interleukin 28B(IL28B) single nucleotide polymorphisms(SNPs) with chronic hepatitis C virus(HCV) infection and response to antiHCV treatment.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Two hundred and fiftythree patients with chronic hepatitis C and compensated cirrhosis, and 83 healthy controls were genotyped for the IL28B rs8099917 polymorphisms by TaqMan system. The relation of IL28B rs8099917 SNPs and chronic HCV infection, and the association of IL28B rs8099917 SNPs and virological responses were analyzed. Chisquare test was performed for comparison of categorical data.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The patients with chronic HCV infection and the healthy controls showed similar frequencies of G, T allele and GG/GT, TT genotypes(P＞005). IL28B rs8099917 SNPs were neither significantly associated with baseline HCV RNA level nor with HCV genotype(P＞005). The presences of IL28B rs8099917 T allele and TT genotype were significantly higher in patients achieved early virological response  and sustained virological response than nonresponse patients.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓In Hebei province, polymorphisms in IL28B rs8099917 were not associated with susceptibility to chronic HCV infection. IL28B rs8099917 T allele and TT genotype were predictors for better virological responses.

Key words: hepatitis C virus, chronic, interleukin28B, polymorphism, single nucleotide

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