关键词: 结核, 多态性, 单核苷酸, Toll样受体2

Abstract: ［Abstract］ Objective〖HTSS〗〓To explore the association of single nucleotide polymorphisms(SNP) in Tolllike receptor 2(TLR2) gene with the susceptibility to tuberculosis(TB).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Two hundred and five cases of normal people and two hundred and fourteen cases of tuberculosis patients were analyzed by the method of microsequencing technology(SNaPshot) in Hebei area via the genotypic and allelic frequencies of TLR2(rs5743708 and rs3804099). The relationship between TLR genotypes and the susceptibility to tuberculosis was analyzed by logistic regression models.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓There was no significant difference between the age and gender of 214 patients with tuberculosis and 205 cases of normal people(P＞005), and the effects of age and gender factor on the results of the study were not statistically significant(P＞005). The distribution of gene frequency in rs5743708 and rs3804099 conformed to the HardyWeinberg equilibrium law by χ2 test. Compared with control group, there were not significant difference on the rs5743708 genotype(χ2=0.925, P=0.925) and allelic frequencies(χ2=0.921, P=0.921), the genotype of rs3804099 loci(χ2=3.388, P=3.388) and allele(χ2=2.843, P=2.843) of TB group(P＞005). The risk of CT genotype at the rs5743708 site was increased compared with the CC genotype, but there was no statistical significance(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The polymorphism of TLR2(rs5743708 and rs3804099) has no significant correlation with the incidence of tuberculosis in the han nationality of hebei province.

Key words: tuberculosis, polymorphism, single nucleotide, Tolllike receptor 2