派瑞松联合丹参酮治疗面部脂溢性皮炎的临床效果研究

doi:10.3969/j.issn.10073205.2018.03.017

河北医科大学学报

派瑞松联合丹参酮治疗面部脂溢性皮炎的临床效果研究

广东省中山市坦背医院皮肤科，广东中山 528414

出版日期:2018-03-25 发布日期:2018-03-27
作者简介:刘全（1976-），男，广西贺州人，广东省中山市坦背医院主治医师，医学学士，从事皮肤性病诊治研究。
基金资助:
中山市卫生和计划生育局医学科研项目（2016J225）

Study on clinical effect of pevisone combined with Tanshinone in treatment of facial seborrheic dermatitis

Department of Dermatology, Tanbei Hospital of Zhongshan, Guangdong Province， Zhongshan 528414， China

Online:2018-03-25 Published:2018-03-27

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗观察派瑞松联合丹参酮治疗面部脂溢性皮炎的临床效果，为临床治疗提供优质方案。
〖HTH〗方法〖HTSS〗〖KG*2〗选择符合研究标准的面部脂溢性皮炎患者120例，按随机数字表法分为观察组与对照组，每组60例。对照组单纯给予派瑞松治疗，观察组在派瑞松治疗的基础上联合丹参酮治疗，比较用药后第2周末及第4周末2组患者症状改善及疗效，4周治疗结束后随访，比较随访复发率及不良反应。
〖HTH〗结果〖HTSS〗〖KG*2〗2组红斑、瘙痒、脱屑以及皮损面积评分均呈降低的趋势，且观察组红斑、瘙痒、脱屑及皮损面积评分均低于对照组，其组间、时点间、组间·时点间交互作用差异有统计学意义（P＜005）。观察组用药平均起效时间明显短于对照组，治疗效果优于对照组，复发率明显低于对照组（P＜005）。2组不良反应发生率差异无统计学意义（P＜005）。
〖HTH〗结论〖HTSS〗〖KG*2〗派瑞松联合丹参酮治疗面部脂溢性皮炎，疗效佳，症状改善明显，不良反应少，复发率低，可在临床推广并作为首选方案给予应用。

关键词: 皮炎, 脂溢性, 派瑞松, 丹参酮

Abstract: ［Abstract］〓Objective〖HTSS〗〓To investigate the clinical effects of pevisone combined with Tanshinone in the treatment of facial seborrheic dermatitis, so as to offer the excellent scheme for clinic treatment.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred twenty patients suffered from facial seborrheic dermatitis who were coincident with research standard were selected and were divided into observation group and control group in accordance with random number table, 60 patients for each group. For patients in control group, pevisone was offered only while for those in observation group, Tanshinone was provided in addition to pevisone treatment. The symptom improvement and effects of patients in two groups on the 2 nd and 4 th weekends after pharmacy were compared. The followup visit was carried out after the treatment for 4 weeks, during which the recurrence rate and adverse reactions were also compared.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The scores of erythema, pruritus, desquamation and psoriasis area of patients in two groups showed a decreasing trend, and the scores of erythema, pruritus, desquamation and psoriasis area of patients in observation group were lower than those of control group, the interactions regarding groups, time points and groups and time points had statistical significance(P＜005). The average drug onset time of observation group was obviously shorter than that of control group, the treatment effect was better than that of control group yet the recurrence rate was obviously lower than that of control group(P＜005). The difference of adverse reaction incidence rates of two groups had no statistical significance(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Pevisone combined with Tanshinone has favorable effects in the treatment of facial seborrheic dermatitis with such contributions as improved clinical symptoms, less adverse reactions and reduced recurrence rate, which should be widely promoted in clinical practice and applied as the preferred option.

Key words: dermatitis, seborrheic, pevisone, Tanshinone

刘〓全，岑小玲，朱世明. 派瑞松联合丹参酮治疗面部脂溢性皮炎的临床效果研究[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2018.03.017.

LIU Quan, CEN Xiaoling, ZHU Shiming. Study on clinical effect of pevisone combined with Tanshinone in treatment of facial seborrheic dermatitis[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2018.03.017.

[1]	凌琬茗, 刘岩, 谷红霞, 赵瑞雪, 韩志敏. CYP1A1、TSLPR、CCR3在小儿特应性皮炎中的表达及与临床特征相关性研究 [J]. 河北医科大学学报, 2022, 43(9): 1052-1056,1061.
[2]	聂子元1，周〓静2，杨高山3，秦〓岩4*. 丹参酮ⅡA通过下调PKM2表达促进慢性髓细胞白血病细胞凋亡[J]. 河北医科大学学报, 2018, 38(12): 1389-1393.
[3]	韩兰芹,张锤,张佳钰. 超脉冲CO2激光联合调Q开关532 nm激光治疗脂溢性角化病的疗效观察[J]. 河北医科大学学报, 2016, 37(4): 400-403.
[4]	褚艳丽;赵荣娟. 干扰素软膏治疗小儿丘疹性肢端皮炎样皮疹效果观察[J]. , 2014, 35(9): 1081-1081.
[5]	温雅;祝春华;王力娜;季辉;刘莹. 丹参酮ⅡA 保护脑梗死大鼠血脑屏障的机制研究[J]. , 2014, 35(8): 869-869.
[6]	苑兰惠;史鸿云;李志刚;杨会彬;盖晓惠;张戈妹. 丹参酮对大鼠放射性肝损伤保护作用的研究[J]. , 2012, 33(3): 339-339.
[7]	张颖. 丹参酮联合2%氯柳酊治疗寻常痤疮260例疗效观察[J]. , 2009, 30(5): 514-514.
[8]	王曙霞;曹海育;高顺强;林元珠. 石家庄地区100例皮肤斑贴试验结果分析[J]. , 2004, 25(1): 41-41.

派瑞松联合丹参酮治疗面部脂溢性皮炎的临床效果研究

Study on clinical effect of pevisone combined with Tanshinone in treatment of facial seborrheic dermatitis

HTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 8

编辑推荐

Metrics

本文评价