关键词: 心脏缺损, 先天性, 体外循环, 右美托咪定, 麻醉

Abstract: ［Abstract］ Objective〖HTSS〗〓To observe the effect of dexmedetomidine on fasttrack anesthesia in children opening cardiac operation by cardiopulmonary bypass(CPB).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 60 children patients undergoing opening cardiac operation by CPB,ASAⅡorⅢ, were randomized two groups. The 30 cases in group D were given dexmedetomidine fasttrack anesthesia. The 30 cases in groups C were conventional fasttrack anesthesia. Patients in group D were received an initial bolus dose of dexmedetomidine(1.0 μg/kg) over 15 min, immediately followed by a comtinuous infusion of 0.4 μg·kg-1·h-1 until the end of the operation. The same volume of normal saline was given in the group C. Heart rate, systolic blood pressure, diastolic blood pressue were measured before injection(T1), 10 min after administration(T2), after incision(T3), 5 min after sternum saw(T4), after CPB(T5), after ectubation(T6). The changes of cardiac troponin I(cTnI) and creatine kinaseMB(CKMB) were measured in T1, T5, T6. Dosage of sufentanil and rocuronium during operation 、mechanical ventilation time and hospital stay length were recorded.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Heart rate, systolic blood pressure, diastolic blood pressue were decreased at T2-T6 in group D than in group C（P＜005）. CKMB and cTnI levels were decreased in group D compared to that in group C at T5, T6（P＜005）. The dosage of sufentanil and rocuronium in group D was lower than that in group C（P＜005）. Compared with group C, mechanical ventilation time and hospitalization time were significantly reduced in group D（P＜005）. 
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Dexmedetomidine can stabilize hemodynamics and protect cardiac function on fasttrack anesthesia in children opening cardiac operation by CPB, which is conducive to the recovery of children and reduces mechanical ventilation time and hospitalization time.

Key words: heart defects, congenital, cardiopulmonary bypass; , dexmetomidine, anesthesia