›› 2014, Vol. 35 ›› Issue (6): 664-664.

• 论文 • 上一篇    下一篇

瞬时弹性成像技术及生化指标在非酒精性单纯性脂肪肝定量诊断中的应用

李岩;杨涛;田海燕   

  1. 河北省人民医院体检中心,河北 石家庄,050000%河北省人民医院泌尿外科,河北 石家庄,050000%河北省胸科医院超声科,河北 石家庄,050000
  • 发布日期:2014-06-25

ZHAO Zhiming;CUI Na;HAO Guimin;XU Suxin

LI Yan;YANG Tao;TIAN Haiyan   

  • Published:2014-06-25

摘要: 目的:探讨瞬时弹性成像( FibroScan)技术及生化指标对非酒精性单纯性脂肪肝( nonalcoholic simple fatty liver,NAFL)的评估价值。方法选取NAFL患者313例及正常健康人300例,均行腹部超声检查、生化检查及FibroScan检查。结果 NAFL组体质量指数( body mass index,BMI)、丙氨酸转氨酶( alanine aminotransferase,ALT)、天冬氨酸转氨酶( aspartate aminotransferase,AST)、空腹血糖( fasting blood glucose,FBG)、总胆固醇( total cholesterol, TC)、三酰甘油( triglyceride,TG)、低密度脂蛋白胆固醇( low density lipoprotein cholesterol,LDL-C)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、肝脏硬度值(liver stiffiness,E)和受控衰减系数(controlled attenuation parameter, CAPTM)高于正常组(P<0.01);高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)低于正常组(P<0.01)。FibroScan检查诊断NAFL的准确率高于彩色超声检查( P<0.01)。CAPTM值与BMI、FBG、TG、HDL-C、E呈正相关(P<0.05或P<0.01)。结论 FibroScan的CAPTM值测定可用于脂肪肝的无创诊断,是对肝脏无损伤的评估与监测脂肪肝的量化工具。

关键词: 脂肪肝, 弹性成像技术, 评价研究

Abstract: Objective The study is to explore the application of transient elastography ( FibroScan)and biological indexes on nonalcoholic fatty liver disease( NAFL)patients. Methods 313 NAFL patients and 300 normal healthy people underwent abdominal ultrasound examination,biochemical examination and FibroScan. Results The body mass index( BMI ),alanine aminotransferase( ALT ), aspartate aminotransferase( AST),fasting blood glucose( FBG),total cholesterol( TC),triglyceride( TG), low density lipoprotein cholesterol( LDL-C ),glycosylated hemoglobin( HbA1 c ),liver stiffiness( E )and controlled attenuation parameter( CAPTM )in NAFL group were higher than those of the normal group (P<0. 01),but high density lipoprotein cholesterol(HDL-C)was lower than that of normal group(P<0 . 01 ). FibroScan examination showed higher diagnostic accuracy for NAFL than ultrasonography( P <0. 01),CAPTM was positively correlated with TG,BMI,FBG,HDL-C,E( P <0. 05 or P <0. 01 ). Conclusion CAPTM in FibroScan is a non-invasive,painless quantitative tool in assessment and monitor of fatty liver.

Key words: fatty liver, elasticity imaging techniques, evaluation studies

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