关键词: 癌, 非小细胞肺, 肿瘤相关巨噬细胞, 细胞增殖因子

Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the expression levels of tumor associated macrophages(TAMs), tumor proliferation factor(Ki67) in nonsmall cell lung cancer(NSCLC) and their relationships with the clinical pathological features, and to study its relationship with prognosis.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Immunohistochemical SP method was used to analyze the expressions of CD68(TAMs surface marker) Ki67 and in 68 cases of NSCLC tissues and 17 cases of normal lung tissues. According to the results of followup, KaplanMeier survival analysis and Cox regression analysis of CD68, Ki67 was used to study its relationship with lung cancer prognosis.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The positive rates of CD68 and Ki67 in 68 cases of lung cancer were 66.2%(45/68) and 61.8%(42/68). The positive expression rates of CD68 and Ki67 in normal lung tissues were 17.6%(3/17) , 5.9%(1/17), the difference was statistically significant(P＜005). The expression of CD68 and Ki67 in NSCLC tissues with high TNM stage, lymph node metastasis and invasion were significantly increased(P＜005).In addition, the expression of Ki67 in poorly differentiated patients increased. There was a positive correlation between CD68 and Ki67 expression in NSCLC(r=0.461, P=0000). Sixtyeight patients with NSCLC 1, 3, 5year survival rate 〖JP2〗were 86.76%, 64.71%, 16.18%. Cox multivariate analysis showed that the low degree of differentiation〖JP〗 and lymph node metastasis are risky factors for adverse prognosis(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓CD68, Ki67positive lung cancer patients with poor prognosis. CD68 and Ki67 play a role in the development, invasion and metastasis of NSCLC, and combined detection of them provide a potential target for clinical diagnosis, adjuvant therapy of NSCLC.

Key words: carcinoma, nonsmallcell lung, tumor associated macrophages, Ki67