关键词: 冠心病, 阿托伐他汀, 炎症因子

Abstract: ［Abstract］ Objective〖HTSS〗〓To explore the effect of atorvastatin in a load capacity and high maintaining dose on the inflammatory cytokines and vascular endothelial function in acute coronary syndrome(ACS) patients underwent percutaneous coronary intervention(PCI).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred and fifty  patients with ACS who underwent PCI were randomly divided into observation group and control group with 75 cases each. Coronary angiography and PCI were performed in both groups, and conventional ACS drugs were given orally. The control group received oral atorvastatin 20 mg/time before going to bed every night. Observed group received oral atorvastatin 80 mg/time before bed every night before PCI, postoperatively reduced to 40 mg/time before going to bed every night, and changed to 20 mg every night before going to bed. Two groups of patients undergo comparative evaluation after 4 weeks, and maintain medication for a minimum of 2 years. Highsensitivity Creactive protein(hsCRP)， tumor necrosing factor alpha(TNFα)， interleukin6(IL6)， interleukin18(IL18)， nitric oxide(NO)， endothelin1(ET1)， von Willebrand factor(vWF)， PSelectin（CD62p）， GPⅡb/Ⅲa were measured before PCI, 1 day after surgery, and 4 weeks after operation in two groups of patients.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The hsCRP, TNFα, IL6 and IL18 levels in both groups were increased first and then decreased, but those in the observation group were decreased more significantly at 4 weeks postoperatively. The two groups had intergroup and time points. There was a statistically significant difference in the interaction between the two groups(P＜005). The NO in both groups were decreased first and then increased, but the increase was greater in the observation group. Both ET1 and vWF were increased first and then decreased, but those in the observation group were decreased more significantly. There was a statistically significant difference in the interactions among groups, time points, and between groups(P＜005). In both groups, CD62p and GPⅡb/Ⅲa were increased first and then decreased, but those in the observation group were decreased more significantly at 4 weeks postoperatively. The interactions among groups, time points, and between groups were similar between the two groups. The difference was statistically significant(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The loading and high maintenance atorvastatin can effectively inhibit the inflammatory response and platelet activation in patients with ACS and effectively improve the vascular endothelial function and cardiac function. It has high application value and is worthy of clinical promotion.

Key words: coronary disease, atorvastatin, inflammatory factors