河北医科大学学报

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2型糖尿病冠心病患者甲状腺功能减退时血清脂联素水平变化的意义

  

  1. 1.承德医学院附属医院内分泌科,河北 承德 067000;2.河北医科大学第二医院内分泌科,河北 石家庄 050000
  • 出版日期:2019-04-25 发布日期:2019-04-22
  • 作者简介:卢亚男(1987-),女,河北承德人,承德医学院附属医院主治医师,医学硕士,从事内分泌疾病诊治研究。
  • 基金资助:
    承德市科学技术研究与发展计划(201701A062)

Features and significance of serum APN level in type 2 diabetic coronary heart disease with Hypothyroidism

  1. 1.Department of Endocrinology, Affiliated Hospital of Chengde Medical College, Hebei Province,
    Chengde 067000, China; 2.Department of Endocrinology, the Second Hospital of
    Hebei Medical University, Shijiazhuang 050000, China
  • Online:2019-04-25 Published:2019-04-22

摘要: [摘要]〓
〖HTH〗目的〖HTSS〗〖KG*2〗观察2型糖尿病冠心病患者甲状腺功能减退时血清脂联素(adiponectin,ANP)水平的变化。
〖HTH〗方法〖HTSS〗〖KG*2〗选取正常对照组(G1组)30例,2型糖尿病患者88例,分为单纯2型糖尿病组(G2组)27例、2型糖尿病合并冠心病组(G3组)34例、2型糖尿病并发冠心病甲状腺功能减退组(G4组)27例。检测糖化血红蛋白(glycated hemoglobin,HbA1c)、总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDLC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDLC)、ANP、甲状腺功能等指标。
〖HTH〗结果〖HTSS〗〖KG*2〗G3组和G4组游离三碘甲状腺原氨酸(free triiodothyronine,FT3)低于G1组和G2组(P<0.05);G4组促甲状腺激素(thyroid stimulating hormone,TSH)高于G1组、G2组和G3组(P<0.05);G2组、G3组和G4组HbA1c高于G1组,G3组高于G2组和G4组(P<0.05);G2组、G3组和G4组ANP低于G1组,G3组和G4组低于G2组,G4组又低于G3组(P<005)。ANP水平与HDLC和FT3呈正相关(P<005),与年龄、TG、TSH、HbA1c呈负相关(P<005)。年龄、HbA1c是2型糖尿病冠心病发生的危险因素,FT3和APN是2型糖尿病冠心病发生的保护因素。
〖HTH〗结论〖HTSS〗〖KG*2〗FT3和APN水平的降低促进了2型糖尿病合并甲状腺功能减退患者冠心病的发生和进展。

关键词: 糖尿病, 2型, 冠心病, 甲状腺功能减退症, 脂联素

Abstract: [Abstract] Objective〖HTSS〗〓To detect the level of serum adiponectin(ANP) and explore the role of hypothyroidism in the development of coronary heart disease(CHD) in type 2 diabetes.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Thirty cases of normal control group(G1 group) were selected. And 88 patients with type 2 diabetes mellitus were divided into simple type 2 diabetes mellitus group(27 cases, G2 group), type 2 diabetes mellitus with CHD group(34 cases, G3 group), type 2 diabetes mellitus with CHD group and hypothyroidism group(27 cases, G4 group). Glycated hemoglobin(HbA1c), total cholesterol(TC), 〖JP2〗triglyceride(TG), high density lipoprotein cholesterol(HDLC),〖JP〗 low density lipoprotein cholesterol(LDLC), ANP levels, thyroid function and other indicators were detected.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The free triiodothyronine(FT3) in G3 group and G4 group was lower than G1 group and G2 group. G4 group thyroid stimulating hormone(TSH) was higher than G1, G2 group and G3 group,  HbA1c in G2, G3 and G4 groups was higher than G1 group, G3 group was higher than G2 group and G4 group. ANP in G2 group, G3 group and G4 group was lower than G1 group, G3 group and G4 group were lower than G2 group, G4 group was lower than G3 group, and the difference was statistically significant(P<005). ANP levels were positively correlated with HDLC and FT3(P<005), It was negatively correlated with age, TG, TSH and HbA1c(P<005). Age and HbA1c are risk factors for CHD in type 2 diabetes, while FT3 and APN are protective factors for CHD in type 2 diabetes.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The decrease of FT3 and APN levels promotes the occurrence and progression of CHD in patients with type 2 diabetes mellitus complicated with hypothyroidism.

Key words: diabetes mellitus, type 2, coronary disease; , hypothyroidism, adiponectin