关键词: 冠状动脉疾病, 载脂蛋白A类, 血管成形术

Abstract: ［Abstract］ Objective〖HTSS〗To observe the relationship between lipoprotein a［Lp(a)］ and the progression of non-culprit coronary lessions after successful stent implantation in culprit lessions.
〖WTHZ〗Methods〖HTSS〗In total, 296 patients who underwent coronary angiograms angain with a time interval from 6 to 12 months after successful stent implantation at culprit lessions were enrolled in our center. The patients were divided into progression group（n=46, 15.5%） and non-progression group（n=250, 84.5%). First, single factor analysis was used to select factors with significant differences between two groups of patients, and then Logistic regression was used to analyze whether the above factors were independent risk factors for non-criminal disease progression after coronary stent implantation.
〖WTHZ〗Results〖HTSS〗Single factor analysis showed the prevalence of diabetes, cardiac ejection fraction, multi-vessel disease, Lp(a), and low-density lipoprotein cholesterol  between two group were statistically  significant(P＜0.05). In univariate analysis, patients of progression group showed higher levels of Lp（a）, higher incidence of multivessel diseases, higher incidence of diabetes, Less reduce of LDL, lower ejection fraction(EF). On multivariate logistic regression analysis, independent predictors of the progression of nonculprit coronary lesions included Lp (a) increase (≥300 mg/L) ，multivessel diseases, diabetes, less reduce of LDL（＜0616 mmol/L), lower EF（＜50%) .
〖WTHZ〗Conclusion〖HTSS〗Lp(a) increase(≥300 mg/L) is an independent risk factor for the progression of non-culprit coronary lessions after successful stent implantation in culprit lessions.

Key words: coronary artery disease, apolipoproteins A, angioplasty