药物球囊治疗冠状动脉小血管病变的效果和不良反应观察

doi:10.3969/j.issn.1007-3205.2022.05.004

河北医科大学学报 ›› 2022, Vol. 43 ›› Issue (5): 517-520.doi: 10.3969/j.issn.1007-3205.2022.05.004

药物球囊治疗冠状动脉小血管病变的效果和不良反应观察

河北医科大学第二医院东院区心内一科，河北石家庄 050031

出版日期:2022-05-25 发布日期:2022-05-30
作者简介:王亚玲(1981-)，女，河北卢龙人，河北医科大学第二医院东院区副主任医师，医学博士，从事心血管疾病诊治研究。
基金资助:
河北省医学科学研究课题计划(20220988)

Observation of the effect and adverse reactions of drug-coated balloon in the treatment of small coronary artery lesions in patients

The First Department of Cardiovascular Medicine, East Branch of the Second Hospital of Hebei Medical University, Shijiazhuang 050031, China

Online:2022-05-25 Published:2022-05-30

摘要/Abstract

摘要：

目的探究紫杉醇药物球囊治疗冠状动脉小血管病变的效果和安全性。

方法选取本院收治的冠状动脉小血管病变患者84例为研究对象，遵循数字随机法将其分为对照组（n=42）、研究组（n=42），对照组开展药物洗脱支架治疗，研究组开展紫杉醇药物球囊治疗。对比两组冠状动脉小血管病变患者不同时间靶血管造影情况及不良心血管事件发生情况。

结果两组患者血管内超声术前预扩后靶病变长度、最小管腔直径、基准管腔直径、管腔狭窄程度等差异无统计学意义（P＞0.05）；手术前后冠状动脉造影对比结果显示,术后最小管腔直径及管腔狭窄程度对照组和研究组均较术前明显改善（P＜0.001），术后6个月管腔狭窄程度研究组较对照组明显减轻（P＜0.05）；从术前到术后6个月最小管腔直径对照组和研究组分别由（0.536±0.132） mm扩大到（2.155±0.272） mm和（0.517±0.127） mm扩大到（2.212±0.264） mm，两组差异有统计学意义（P＜0.05）；从术前到术后6个月管腔狭窄程度对照组和研究组分别由（78.50±4.87）%降至（13.50±10.56）%和（78.62±5.48）%降至（8.93±8.43）%，两组差异有统计学意义（P＜0.05）；术后12个月，研究组患者不良心血管事件发生率低于对照组，差异有统计学意义（P＜0.05）。

结论采取紫杉醇药物球囊治疗冠状动脉小血管病变，对降低晚期靶血管重建、残余狭窄程度有显著效果，且能有效减少不良心血管事件，提升临床安全性。

关键词: 冠状动脉疾病, 药物洗脱支架, 紫杉醇, 药物球囊

Abstract:

Objective To explore the efficacy and safety of paclitaxel drug-eluting balloon in the treatment of small coronary artery lesions.

Methods A total of 84 patients with small coronary artery lesions admitted to this hospital were selected as the subjects of this study. They were divided into the control group(n=42) and the research group(n=42) according to the numerical randomization method. The control group was given drug-eluting stent therapy, while the research group was given paclitaxel drug-eluting balloon therapy. The target angiography and adverse cardiovascular events at different time points were compared between two groups of patients with small coronary artery lesions.

Results There were no significant differences in target lesion length, minimum lumen diameter, reference lumen diameter, and lumen stenosis before surgery and after pre-dilation of intravascular ultrasound between two groups(P＞0.05). Comparison of coronary angiography before and after surgery showed that the minimum lumen diameter and the degree of residual stenosis of two groups were improved after operation(P＜0.001). The degree of lumen stenosis in the research group at 6 months after operation was significantly lower than that in the control group(P＜0.05). The minimum lumen diameter increased from (0.536±0.132) mm to (2.155±0.272) mm in the control group and from (0.517±0.127) mm to (2.212±0.264) mm in the research group(P＜0.05) at 6 months after operation, as compared with those before operation, and the difference was statistically significant. In addition, the degree of residual stenosis reduced from (78.50±4.87) % to (13.50±10.56) % in the control group and from (78.62±5.48) % to (8.93±8.43) % in the research group, and the difference was statistically significant(P＜0.05). At 12 months after operation, the incidence of adverse cardiovascular events in the research group was lower than that in the control group, and the difference was statistically significant(P＜0.05).

Conclusion The use of paclitaxel drug-eluting balloon to treat small coronary artery lesions has significant effects on reducing late target vessel reconstruction and residual stenosis, which can effectively reduce adverse cardiovascular events and improve clinical safety.

Key words: coronary artery disease, drug-eluting stents, taxol, drug-eluting balloon

王亚玲, 饶明月, 郭安君, 张杨, 孟建康. 药物球囊治疗冠状动脉小血管病变的效果和不良反应观察[J]. 河北医科大学学报, 2022, 43(5): 517-520.

WANG Ya-ling, RAO Ming-yue, GUO An-jun, ZHANG Yang, MENG Jian-kang. Observation of the effect and adverse reactions of drug-coated balloon in the treatment of small coronary artery lesions in patients[J]. Journal of Hebei Medical University, 2022, 43(5): 517-520.

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药物球囊治疗冠状动脉小血管病变的效果和不良反应观察

Observation of the effect and adverse reactions of drug-coated balloon in the treatment of small coronary artery lesions in patients

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