术前强化阿托伐他汀联合充分水化疗法对PCI术后并发造影剂肾病的影响

doi:10.3969/j.issn.10073205.2017.03.004

河北医科大学学报

术前强化阿托伐他汀联合充分水化疗法对PCI术后并发造影剂肾病的影响

1.河北省保定市第二中心医院心内1科，河北保定 072750；2.河北省保定市第三中心医院肾内科，河北保定 071000

出版日期:2017-03-25 发布日期:2017-03-29
作者简介:李然（1976），女，河北涿州人，河北省保定市第二中心医院副主任医师，医学硕士，从事心血管内科疾病诊治研究。

Effect of intensive atorvastatin before operation combined with full hydration therapy on contrast induced nephropathy in patients after PCI

1.First Department of Cardiology， the Center Hospitol of Baoding City， Hebei Province， Baoding 072750， China；
2.Department of Nephrology, the Third Center Hospital of Baoding City, Hebei Province, Baoding 071000, China

Online:2017-03-25 Published:2017-03-29

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨术前强化阿托伐他汀联合充分水化疗法对经皮冠状动脉介入（percutaneous coronary intervention,PCI）术后并发造影剂肾病（contrast induced nephrapathy,CIN）的影响。
〖HTH〗方法〖HTSS〗〖KG*2〗将92例择期行PCI手术的冠心病患者随机分为强化组和常规组，每组46例。强化组给予术前强化阿托伐他汀联合充分水化疗法，常规组给予常规剂量阿托伐他汀联合充分水化疗法。比较不同时点血清肌酐（serum creatine,SCr）、尿素氮（blood urea nitrogen,BUN）和尿β2微球蛋白（β2microglobulin，β2MG）水平变化和CIN发生率。
〖HTH〗结果〖HTSS〗〖KG*2〗强化组和常规组SCr、BUN和尿β2MG水平随时间延长而呈现出先升高后降低的趋势，强化组变化幅度较小，组间、时点间、组间·时点间交互作用差异均有统计学意义（P＜005）。2组CIN发生率比较差异无统计学意义(P＞005)。
〖HTH〗结论〖HTSS〗〖KG*2〗术前强化阿托伐他汀联合充分水化疗法可保护PCI手术患者肾功能。

关键词: 肾病, 经皮冠脉介入治疗, 阿托伐他汀

Abstract: ［Abstract］ Objective〖HTSS〗〓To discuss the effect of intensive atorvastatin before operation combined with full hydration therapy on contrast induced nephropathy(CIN) in patients after percutaneous coronary intervention(PCI) .
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Ninetytwo cases of patients with coronary heart disease undergoing elective PCI surgery treated in our hospital were randomly divided into intensive group and conventional group, with 46 cases in either group. The intensive group were given intensive atorvastatin before operation combined with full hydration therapy, while the conventional group were given conventional atorvastatin combined with full hydration therapy. The changes of levels of serum creatinine(SCr),blood urea nitrogen(BUN) and urinary β2microglobulin(β2MG) at different moments and the incidence rates of CIN were compared between the two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The levels of SCr, BUN and β2MG in the intensive group and the conventional group showed a trend of increasing first and then decreasing with the time extension. The change range of the intensive group was smaller, There were significant differences between the two groups、time point and effect each other(P＜005). There was no significant difference in the incidence of CIN between the two groups(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The intensive atorvastatin before operation combined with full hydration therapy protect the renal function of patients undergoing PCI surgery.

Key words: nephrosis, percutaneous coronary intervention, atorvastatin

李〓然1，王德良1，王文素2. 术前强化阿托伐他汀联合充分水化疗法对PCI术后并发造影剂肾病的影响[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2017.03.004.

LI Ran1， WANG Deliang1， WANG Wensu2. Effect of intensive atorvastatin before operation combined with full hydration therapy on contrast induced nephropathy in patients after PCI[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2017.03.004.

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术前强化阿托伐他汀联合充分水化疗法对PCI术后并发造影剂肾病的影响

Effect of intensive atorvastatin before operation combined with full hydration therapy on contrast induced nephropathy in patients after PCI

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