河北医科大学学报 ›› 2021, Vol. 42 ›› Issue (9): 1027-1031.doi: 10.3969/j.issn.1007-3205.2021.09.007

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IRF1、IRF8水平与2型糖尿病肾病患者颈动脉粥样硬化的关系

  

  1. 安徽省芜湖市第二人民医院肾内科，安徽 芜湖 241000
  • 出版日期:2021-09-25 发布日期:2021-09-28
  • 作者简介:姜姣姣（1983-），女，安徽毫州人，安徽省芜湖市第二人民医院主治医师，医学硕士研究生，从事肾内科疾病诊治研究。
  • 基金资助:
    安徽省教育厅高校自然科学研究重点项目（KJ2020A0219）

Correlation between IRF1, IRF8 levels and carotid atherosclerosis in patients with type 2 diabetic nephropathy

  1. Department of Nephrology, the Second People′s Hospital of Wuhu City, Anhui Province, Wuhu 241000, China
  • Online:2021-09-25 Published:2021-09-28

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摘要： 目的 观察干扰素调节因子1（interferon regulatory facto 1，IRF1）、IRF8水平与2型糖尿病肾病（type 2 diabetic nephropathy，T2DN）患者颈动脉粥样硬化的相关性。
方法 选取149例符合条件的T2DN患者作为研究对象，均于患者入院时收集基线资料，检测血清标志物［C反应蛋白（C-reactive protein，CRP）、纤维蛋白原（fibrinogen，FIB）］、IRF1、IRF8水平，全部患者均接受6个月的治疗，均于治疗6个月时行彩色超声检查，评估患者有无颈动脉粥样硬化。根据颈动脉粥样硬化评估结果将患者分为颈动脉粥样硬化组与无颈动脉粥样硬化组。采用多因素回归分析T2DN患者颈动脉粥样硬化的危险因素，绘制受试者工作曲线（receiver operating curve，ROC）分析血清标志物、IRF1、IRF8水平对T2DN患者颈动脉粥样硬化的预测效能。
结果 治疗6个月时，行彩色超声检查显示，149例T2DN患者中，有68例发生颈动脉粥样硬化，发生率为45.64%；初步比较发生与未发生颈动脉粥样硬化患者的基线资料后，经回归分析检验结果显示，入院时CRP、FIB、IRF1、IRF8表达上调与T2DN患者颈动脉粥样硬化的发生有关，可能是T2DN患者颈动脉粥样硬化发生的风险因子（OR＞1，P＜0.05）；ROC发现，T2DN患者入院时CRP、FIB、IRF1、IRF8水平预测颈动脉粥样硬化的的曲线下面积（area under curve，AUC）均＞0.80，均有一定预测价值。
结论 T2DN患者颈动脉粥样硬化发生风险高，CRP、FIB、IRF1、IRF8水平是T2DN患者颈动脉粥样硬化发生的危险因素，各指标水平表达上调可能提示患者颈动脉粥样硬化发生风险高，其中IRF1、IRF8水平可作为预测T2DN患者颈动脉粥样硬化发生的重要辅助手段。


关键词: 糖尿病肾病, 干扰素调节因子1, C反应蛋白质

Abstract: Objective To observe the correlation between the levels of interferon regulatory factor 1(IRF1), interferon regulatory factor 8(IRF8) and carotid atherosclerosis(CAS) in patients with type 2 diabetic nephropathy(T2DN). 
Methods A total of 149 eligible patients with T2DN treated were selected as the research subjects, and the baseline data of patients at admission were collected. The levels of serum markers ［C-reactive protein(CRP), fibrinogen(FIB)］, IRF1 and IRF8 were detected, and all patients received 6 months of treatment. All patients underwent color Doppler ultrasound examination at 6 months after treatment, and the patients were evaluated for CAS. According to the evaluation results of CAS, the patients were divided into the CAS group and the non-CAS group. Multivariate regression analysis was used to examine the risk factors of CAS in T2DN patients, and the receiver operating curve(ROC) was drawn to analyze the predictive efficacy of serum markers, IRF1 and IRF8 levels on CAS in patients with T2DN. 
Results At 6 months after treatment, color Doppler ultrasound examination showed that among 149 cases of patients with T2DN, 68 cases had CAS, and the incidence was 45.64%. After preliminary comparison of baseline data of patients with and without CAS, regression analysis results showed that the up-regulation of CRP, FIB, IRF1 and IRF8 expression at admission was related to the occurrence of CAS in T2DN patients, which might be a risk factor of CAS in T2DN patients(OR＞1, P＜0.05).  Area under curve(AUC) of CRP, FIB, IRF1 and IRF8 levels in predicting CAS in T2DN patients at admission was all >0.80, which had certain predictive value. 
Conclusion The risk of CAS in patients with T2DN is high. The levels of CRP, FIB, IRF1 and IRF8 are risk factors of CAS in T2DN. The up-regulated expression of each index may indicate a high risk of CAS of patients, of which IRF1 and IRF8 levels can be used as an important auxiliary means to predict CAS in patients with T2DN.


Key words: diabetic nephropathie, interferon regulatory factor 1, C-reactive protein

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