河北医科大学学报 ›› 2021, Vol. 42 ›› Issue (12): 1406-1410.doi: 10.3969/j.issn.1007-3205.2021.12.009

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糖尿病肾病高尿酸血症的危险因素研究

  

  1. 1.河北省保定市第一中心医院肾内科，河北 保定071000； 2.承德医学院附属保定市第一中心医院心内科，
    河北 保定 071000；3.河北省保定市第一中心医院中医科，河北 保定 071000；4.河北省保定市第一中心医院
    内分泌科，河北 保定 071000
  • 出版日期:2021-12-25 发布日期:2021-12-27
  • 作者简介:李晓东（1979-），男，河北唐县人，河北省保定市第一中心医院副主任医师，医学硕士，从事肾脏疾病诊治研究。
  • 基金资助:
    国家自然科学基金资助项目（81500644）；河北省医学适用技术跟踪项目（GZ2020067）

Research on risk factors of hyperuricemia in diabetic nephropathy

  1. 1.Department of Nephrology, the First Central Hospital of Baoding City, Hebei Province, Baoding  
    071000, China; 2.Department of Cardiology, the First Central Hospital of Baoding City Affiliated to 
    Chengde  Medical College, Hebei Province, Baoding 071000, China; 3.Department of 
    Traditional Chinese Medicine, the First Central Hospital of Baoding City, 
    Hebei Province, Baoding 071000, China; 4.Department of  
    Endocrinology, the First Central Hospital of Baoding City, 
    Hebei Province, Baoding 071000, China
  • Online:2021-12-25 Published:2021-12-27

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摘要： 目的 探讨糖尿病肾病（diabetic nephropathy，DN）糖尿病(diabetes mellitus，DM)高尿酸血症的危险因素。
方法 选取河北省保定市第一中心医院入院的2型DM患者350 例，分为高尿酸组（观察组）150例及血尿酸正常组（对照组）200例，比较两组一般特征和临床参数，对于有统计学差异的变量进行二元Logistic回归统计分析。
结果 观察组体重指数（body mass index，BMI）、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol，LDL-C)、糖化血红蛋白A1c(hemoglobin A1c，HbA1c)、24 h尿蛋白（24 hours urinary protein，24 hUpro）、C反应蛋白（C-reactive protein，CRP）、血清肌酐(serum creatinine，SCr)高于对照组（P＜0.05）。回归分析结果显示，BMI、CRP、LDL-C、24 hUpro是DN的高尿酸血症独立相关因素（P＜0.05）。
结论 DN高尿酸血症患者的独立危险因素包括BMI、CRP、LDL-C、24 hUpro，积极采取早期诊断和早期治疗相关措施，可有望延长DN患者的生存期。


关键词: 糖尿病肾病, 高尿酸血症, 危险因素

Abstract: Objective  To explore the risk factors of hyperuricemia(HU) in diabetic nephropathy(DN) patients. 
Methods  In total, 350 patients with type 2 DM admitted to the First Central Hospital of Baoding City, Hebei Province, were divided into the HU group(observation group, n=150) and the normal serum uric acid group(control group, n=200). The general characteristics and clinical parameters of the two groups were compared, and the variables with statistical differences were statistically analyzed by binary Logistic regression. 
Results  The body mass index(BMI), low density lipoprotein-cholesterol(LDL-C), glycosylated hemoglobin A1c(HbA1c), 24 hour urinary protein(24 hUpro), C-reactive protein(CRP) and serum creatinine(SCr) in the observation group were higher than those in the control group(P＜0.05). The results of regression analysis showed that BMI, CRP, LDL-C and 24hUpro were independent related factors of HU in DN(P＜0.05). 
Conclusion  The independent risk factors of  HU in DN patients are BMI,CRP, LDL-C, and 24hUpro in our study.Therefore, early diagnosis and treatment-related measures should be carried out to extend the survival of patients with DN.


Key words: diabetic nephropathy, hyperuricemia, risk factors

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