经外周静脉移植脐带间充质干细胞治疗乙型肝炎肝硬化的效果观察

doi:10.3969/j.issn.10073205.2017.03.006

河北医科大学学报

经外周静脉移植脐带间充质干细胞治疗乙型肝炎肝硬化的效果观察

河北医科大学第一医院中西医结合肝病诊疗中心，河北石家庄 050031

出版日期:2017-03-25 发布日期:2017-03-29
作者简介:张岁（1982-），女，河北辛集人，河北医科大学第一医院主治医师，医学硕士，从事肝脏疾病诊治研究。
基金资助:
河北省医学科学研究重点课题（20150636）

Therapeutic effect of human umbilical cord mesenchymal stem cells transplantation via peripheral vein in the treatment of hepatitis B liver cirrhosis#br#

Department of Live Disease Diagnoses and Treatment Center of Chinese Western Medicine, the First Hospital of Hebei Medical University, Shijiazhuang 050031, China

Online:2017-03-25 Published:2017-03-29

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗评价经外周静脉移植脐带间充质干细胞治疗乙型肝炎肝硬化的临床效果。
〖HTH〗方法〖HTSS〗〖KG*2〗选择乙型肝炎肝硬化患者60例，分为治疗组和对照组各30例，治疗组在内科综合治疗的基础上给予脐带间充质干细胞移植治疗，对照组给予内科综合治疗。观察2组治疗后2、4、12、24周生化指标变化情况、临床症状改善情况及不良反应发生情况。
〖HTH〗结果〖HTSS〗〖KG*2〗治疗4周后，治疗组乏力、腹胀、食欲、腹腔积液改善率均高于对照组，差异有统计学意义（P＜005）。2组随治疗时间延长丙氨酸转氨酶、天冬氨酸转氨酶、总胆红素均呈下降趋势，时点间差异有统计学意义（P＜005），组间、组间·时点间交互作用差异无统计学意义（P＞005）；白蛋白、胆碱酯酶、凝血酶原活动度均呈升高趋势，时点间、组间·时点间交互作用差异有统计学意义（P＜005），组间差异无统计学意义（P＞005）。2组均未发生不良反应和并发症。
〖HTH〗结论〖HTSS〗〖KG*2〗经外周静脉移植脐带间充质干细胞治疗乙型肝炎肝硬化安全有效。

关键词: 肝硬化, 乙型肝炎, 间质干细胞移植

Abstract: ［Abstract］ Objective〖HTSS〗〓To evaluate the curative effect of peripheral vein transplant human umbilical cord mesenchymal stem cells on patients with hepatitis B liver cirrhosis.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Sixty patients with hepatitis B liver cirrhosis were equally divided into treatment group and control group. The treatment group was given umbilical cord mesenchymal stem cell transplantation on the basis of comprehensive medical treatment and the control group was adapted with the comprehensive medical treatment. The changes of biochemical indexes, clinical symptoms and the occurrence of adverse reactions at 2, 4, 12 and 24 weeks before and after treatment were observed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓After 4week treatment, the improvement rate of fatigue, abdominal distension, appetite and ascites in the treatment group were higher than that in the control group and the differences have statistical significance(P＜005). With time extension, alanine aminotransferase, aspartate aminotransferase and total bilirubin of the two groups were decreased, there was significant difference of time dissimilarity between two groups(P＜005), but there were no significant differences of interblock and interaction of interblock with time dissimilarity between two groups(P＞005). The albumin, cholinesterase and prothrombin activity showed an increasing trend and there were significant differences of time dissimilarity and interaction of interblock with time dissimilarity between two groups(P＜005), but there was no significant difference of interblock between two groups(P＞005). There were no suffered severe complications and adverse reactions in all groups.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Human umbilical cord mesenchymal stem cell transplantation via peripheral vein in the treatment of hepatitis B liver cirrhosis is safe and effective.

Key words: liver cirrhosis, hepatitis Ｂ, mesenchymal stem cell transplantation

张〓岁，贾〓蓓，郭翠敏，王海舫，周〓靖*. 经外周静脉移植脐带间充质干细胞治疗乙型肝炎肝硬化的效果观察[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2017.03.006.

ZHANG Sui， JIA Bei， GUO Cuimin, WANG Haifang, ZHOU Jing*. Therapeutic effect of human umbilical cord mesenchymal stem cells transplantation via peripheral vein in the treatment of hepatitis B liver cirrhosis#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2017.03.006.

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经外周静脉移植脐带间充质干细胞治疗乙型肝炎肝硬化的效果观察

Therapeutic effect of human umbilical cord mesenchymal stem cells transplantation via peripheral vein in the treatment of hepatitis B liver cirrhosis#br#

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