孟鲁司特钠联合糠酸莫米松对轻中度腺样体肥大患儿TGFβ1、IL17及Th17/Treg的影响

doi:10.3969/j.issn.10073205.2018.04.015

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗观察孟鲁司特钠联合糠酸莫米松治疗轻中度腺样体肥大患儿的效果以及对血清TGFβ1、IL17和Th17/Treg的影响。
〖HTH〗方法〖HTSS〗〖KG*2〗将98例轻中度腺样体肥大患儿根据病因（慢性炎症为1组，过敏性鼻炎为2组）和治疗方法分为4组：对照1组（22例）、对照2组（27例）、观察1组（24例）、观察2组（25例）。对照组应用糠酸莫米松治疗，观察组在对照组基础上加用孟鲁司特钠，治疗时间为2个月。采用OSA18量表对4组进行症状评分，比较4组治疗前后腺样体与鼻咽腔比值（adenoids to nasopharynx，A/N）及临床疗效，并检测4组治疗前后血清转化生长因子β1（transforming growth factorβ1,TGFβ1）、白细胞介素17(interleukin 17,IL17)及辅助性T细胞17（T helper 17 cells,Th17）/调节性T细胞（regulatory T cells,Treg）的变化，观察4组的不良反应。
〖HTH〗结果〖HTSS〗〖KG*2〗治疗后，4组临床症状评分和A/N值均显著低于治疗前，且观察1组和观察2组均显著低于对照1组和对照2组，差异有统计学意义（P＜005）。4组临床疗效和总有效率差异均有统计学意义（P＜005）。治疗后，4组血清TGFβ1和IL17均显著低于治疗前，且观察1组和观察2组均显著低于对照1组和对照2组，差异有统计学意义（P＜005）。治疗后，4组Th17和Th17/Treg均显著低于治疗前，Treg显著高于治疗前，且观察1组和观察2组Th17和Th17/Treg均显著低于对照1组和对照2组，Treg显著高于对照1组和对照2组，差异有统计学意义（P＜005）。
〖HTH〗结论〖HTSS〗〖KG*2〗孟鲁司特钠联合糠酸莫米松能有效治疗轻中度腺样体肥大，降低外周血血清TGFβ1和IL17水平，减轻炎症反应，同时下调Th17/Treg比例，调节患儿免疫平衡；对炎症和过敏性鼻炎引起的轻中度腺样体肥大安全有效。

关键词: 增殖腺, 孟鲁司特钠, 糠酸莫米松, 儿童

Abstract: ［Abstract］〓Objective〖HTSS〗〓To analyze the clinical effect of montelukast sodium tablet combined with mometasone furoate in the treatment of mild to moderate adenoidal hypertrophy and influence on serum TGFβ1, IL17 and Th17/Treg.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Ninetyeight cases of mild to moderate adenoidal hypertrophy child patients were divided into 4 groups according to the pathogeny and treating method： control group 1(22 cases), control group 2(27 cases), observation group 1(24 cases), observation group 2(25 cases). The control group was treated with mometasone furoate nasal spray, while observation group was treated with mometasone furoate combined with montelukast tablet. All patients were treated for 2 months. OSA18 scale score was used to evaluate the clinical effect, the ratio of adenoids to nasopharynx(A/N) of 4 groups before and after treatment were compared. The clinical effect, serum transforming growth factorβ(TGFβ1), interleukin 17(IL17) level and T helper 17 cells/regulatory T cells(Th17/Treg) of 4 groups were compared. The adverse effect was observed, too.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓After treatment, The OSA18 score and A/N of all groups were decreased significantly（P＜005）, and that of observation group 1 and observation group 2 were significantly lower than control group 1 and control group 2,which showed significant difference（P＜005）. The clinical total effect of four groups showed significant difference（P＜005）. The serum TGFβ1, IL17 level of all group were decreased significantly, and that of observation group 1 and observation group 2 were significantly lower than control group 1 and control group 2, which showed significant difference（P＜005）. After treatment, the Th17 and Th17/Treg ratio of all groups were decreased significantly, the Treg of all groups were increased significantly. The Th17 and Th17/Treg of observation group 1 and observation group 2 were significantly lowerr than control groups, the Treg of observation group 1 and observation group 2 were significantly higher than control groups（P＜005）, which showed significant difference.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Montelukast sodium tablet combined with mometasone furoate can effectively cure mild to moderate adenoidal hypertrophy, decrease the serum TGFβ1 and IL17 level, relief the inflammatory reaction, and downregulate the ratio of Th17/Treg, adjust the immune balance, which is safe and effective for mild to moderate adenoidal hypertrophy caused by chronic inflammation and rhinallergosis, and is worthy of promotion.

Key words: adenoids, montelukast sodium, mometasone furoate, child

黎润球，何锦添，叶贝华. 孟鲁司特钠联合糠酸莫米松对轻中度腺样体肥大患儿TGFβ1、IL17及Th17/Treg的影响[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2018.04.015.

LI Runqiu, HE Jintian, YE Beihua. Effect of montelukast sodium combined with mometasone furoate on TGFβ1, IL17 and Th17/Treg in patients with mild to moderate adenoid hypertrophy#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2018.04.015.

[1]	磨焕鹏, 胡东辉, 邓妙芳, 张亚忠, 何晖. 经皮交叉克氏针内固定治疗儿童Gartland Ⅲ型肱骨髁上骨折的疗效 [J]. 河北医科大学学报, 2023, 44(2): 184-188,235.
[2]	张文超, 赵梦川, 何宝花, 贾肇一, 李梅, 郭映辉. 血流感染患儿流感嗜血杆菌流行特征及耐药性 [J]. 河北医科大学学报, 2023, 44(12): 1467-1471.
[3]	田苡任, 任强, 周湘, 甄磊, 郑美娜, 张放. 3~6岁儿童寰枢椎椎弓根在3D打印技术下的测量研究[J]. 河北医科大学学报, 2022, 43(3): 311-315，325.
[4]	张晓双, 黄珊珊, 闫红, 徐茜茹, 杜鸿飞, 张佳佳. 石家庄地区16 490例过敏患儿过敏原分布特征分析[J]. 河北医科大学学报, 2022, 43(3): 345-349.
[5]	吴会芳, 张景丽, 刘晓娟, 吴晓杰, 段晨初, 张中平. HMGB1、GM-CSF、LDH在慢性肺炎患儿中的表达及相关性研究 [J]. 河北医科大学学报, 2022, 43(10): 1158-1162.
[6]	温婵, 张丽霞, 孙玲. 2011-2019年河北某儿童医院耐甲氧西林金黄色葡萄球菌分布特点及耐药性变迁[J]. 河北医科大学学报, 2022, 43(1): 84-87.
[7]	赵宁, 贺新建, 李易明. 超声心动图改善儿童PICC尖端右心异位的评估研究[J]. 河北医科大学学报, 2021, 42(5): 592-596.
[8]	周辉, 仲智勇. 一种儿童完全植入式静脉输液港尖端定位中的新型方法及应用[J]. 河北医科大学学报, 2021, 42(5): 603-606.
[9]	白磊鹏, 吕家兴, 王瑜, 孔庆柱, 金宇, 赵景新. 经皮穿针联合外固定架微创治疗大龄儿童肱骨近端骨折的效果分析[J]. 河北医科大学学报, 2021, 42(4): 420-424.
[10]	谷海飞, 李超, 张明, 杜文康. 肺保护性通气策略联合不同剂量顺式阿曲库铵对小儿日间腹腔镜手术的影响[J]. 河北医科大学学报, 2021, 42(2): 231-234.
[11]	郑芳, 卞相丽, 李妙晨, 吴志敏. 沙美特罗替卡松气雾剂联合粉尘螨滴剂舌下免疫治疗尘螨过敏性哮喘的临床效果[J]. 河北医科大学学报, 2021, 42(10): 1180-1184.
[12]	赵汝莲，王阳，皮练鸿*. 儿童轻度过敏性结膜炎中干眼的研究及治疗[J]. 河北医科大学学报, 2020, 41(9): 1065-1069.
[13]	弭莉1，杜潘艳2. 儿童支原体肺炎急性期2种检测方法的比较及意义#br#[J]. 河北医科大学学报, 2020, 41(7): 834-837.
[14]	齐文辉，王忠义，徐志杰，苗国瑞. 麻醉诱导前视听干预对学龄前患儿术后行为异常的影响[J]. 河北医科大学学报, 2020, 41(2): 235-238.
[15]	阎雪1，皮亚雷1，张亚男1，崇禾萌1，张会丰1*，吴志焕2. Wililams-Beuren综合征病例分析#br#[J]. 河北医科大学学报, 2020, 41(2): 241-245.

孟鲁司特钠联合糠酸莫米松对轻中度腺样体肥大患儿TGFβ1、IL17及Th17/Treg的影响

Effect of montelukast sodium combined with mometasone furoate on TGFβ1, IL17 and Th17/Treg in patients with mild to moderate adenoid hypertrophy#br#

HTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价