家庄市汉族初诊Graves病儿童25羟维生素D状况分析

doi:10.3969/j.issn.10073205.2019.05.013

河北医科大学学报

家庄市汉族初诊Graves病儿童25羟维生素D状况分析

1.河北医科大学第二医院小儿内科，河北石家庄 050000；2.河北省临城县人民医院儿科，河北临城 054300；
3.河北医科大学第二医院核医学科，河北石家庄 050000

出版日期:2019-05-25 发布日期:2019-05-22
作者简介:皮亚雷(1982-)，女，河北行唐人，河北医科大学第二医主治医师，医学硕士，从事小儿内科疾病诊治研究。
基金资助:
河北省医学科学研究重点课题（20160550）

Analysis of 25 hydroxyvitamin D status in newly diagnosed Han children with Graves disease in Shijiazhuang city#br#

1.Department of Pediatrics, the Second Hospital of Hebei Medical University, Shijiazhuang
050000, China; 2.Departmentof Pediatrics,People′s Hospital of Lincheng County, Hebei
Province， Lincheng 054300, China; 3.Department of Nuclear Medicine, the Second
Hospital of Hebei Medical University, Shijiazhuang 050000, China

Online:2019-05-25 Published:2019-05-22

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨Graves病患儿的维生素D状况及维生素D在Graves病发病机制中的作用。
〖HTH〗方法〖HTSS〗〖KG*2〗选择石家庄市汉族Graves病患儿37例。按初诊时间分为夏秋季组（初诊时间6—11月）及冬春季组（初诊时间12月—次年5月）；按年龄分为＜10岁组及≥10岁组。所有患儿采集空腹静脉血4 mL，测定促甲状腺激素、总甲状腺素、游离甲状腺素、总三碘甲腺原氨酸、游离三碘甲腺原氨酸、促甲状腺激素受体抗体、甲状腺球蛋白、甲状腺球蛋白抗体及25羟维生素D水平；超声测定甲状腺左叶和右叶长、宽、厚度，计算甲状腺体积；口服131碘法测定3，6，24 h吸碘率；电化学法测定中段尿尿碘。
〖HTH〗结果〖HTSS〗〖KG*2〗37例Graves病患儿25羟维生素D水平为（49.95±22.82） nmol/L，缺乏者11例（29.73%），不足者4例（10.81%），充足者22例（59.46%）。夏秋季组25羟维生素D水平高于冬春季组（P＜005）。年龄＜10岁组与≥10岁组25羟维生素D水平差异无统计学意义（P＞005）。血清25羟维生素D水平与甲状腺体积、总甲状腺素、游离甲状腺素、总三碘甲腺原氨酸、游离三碘甲腺原氨酸、尿碘、3 h131碘吸碘率、6 h131碘吸碘率、24 h 131碘吸碘率均无相关性（P＞005）。
〖HTH〗结论〖HTSS〗〖KG*2〗Graves病患儿血清25羟维生素D水平未见明显降低，季节性变化仍然存在；血清25羟维生素D水平并不影响Graves病患儿实验室及临床参数。

关键词: 格雷夫斯病, 25羟维生素D, 儿童

Abstract: ［Abstract］〓Objective〖HTSS〗〓To investigate the 25 hydroxyvitamin D status in children with Graves disease and the role of vitamin D in the pathogenesis of Graves disease.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Thirtyseven children with Graves disease in Shijiazhuang Han nationality were selected. The patients were divided into summerautumn group(JuneNovember) and winterspring group(December to May of the following year) according to the time of their first visit, and < 10 years old group and ≥10 years old group according to the age. Four milliliters of fasting venous blood were collected to test thyrotropin, total thyroxin, free thyroxine,total triiodothyronine, free triiodothyronine, thyrotropin receptor antibody and thyroglobulin, thyroglobulin antibody, 25 hydroxyvitamin D level; The lengths, widths and thicknesses of the right and left lobes of the thyroid were measured by ultrasound and the volume of thyroid was calculated. The iodine uptake rate of 3, 6 and 24hour were measured by oral 131I method, and the iodine in the midstream urine was measured by electrochemical method.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The level of 25 hydroxyvitamin D in 37 children with Graves disease was（49.95±22.82） nmol/L, 11 cases(29.73%)were deficient, 4 cases(10.81%) were insufficient and 22 cases(59.46%) were sufficient. The levels of 25 hydroxyvitamin D in the summerautumn group was higher than the winterspring group(P＜005).The 25 hydroxyvitamin D level was no significant difference between <10 years old group and ≥10 years old(P＞005). There were no correlations between serum 25 hydroxyvitamin D level and thyroid volume,total thyroxin, free thyroxine, total triiodothyronine, free triiodothyronine, urine iodine, 131I iodine absorption rate at 3, 6 and 24hour(P＞0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The serum level of 25 hydroxyvitamin D in children with Graves disease was not significantly decreased, and the seasonal changes were still present. The level of serum 25 hydroxyvitamin D does not affect the laboratory and clinical parameters of children with Graves disease.

Key words: Graves disease, 25hydroxyvitamin D, child

皮亚雷1，张亚男1，韩〓笑1，杨秀献2，高丽萍3，阎〓雪1*. 家庄市汉族初诊Graves病儿童25羟维生素D状况分析[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2019.05.013.

PI Yalei1, ZHANG Yanan1, HAN Xiao1, YANG Xiuxian2, GAO Liping3, YAN Xue1*. Analysis of 25 hydroxyvitamin D status in newly diagnosed Han children with Graves disease in Shijiazhuang city#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2019.05.013.

[1]	磨焕鹏, 胡东辉, 邓妙芳, 张亚忠, 何晖. 经皮交叉克氏针内固定治疗儿童Gartland Ⅲ型肱骨髁上骨折的疗效 [J]. 河北医科大学学报, 2023, 44(2): 184-188,235.
[2]	张文超, 赵梦川, 何宝花, 贾肇一, 李梅, 郭映辉. 血流感染患儿流感嗜血杆菌流行特征及耐药性 [J]. 河北医科大学学报, 2023, 44(12): 1467-1471.
[3]	田苡任, 任强, 周湘, 甄磊, 郑美娜, 张放. 3~6岁儿童寰枢椎椎弓根在3D打印技术下的测量研究[J]. 河北医科大学学报, 2022, 43(3): 311-315，325.
[4]	张晓双, 黄珊珊, 闫红, 徐茜茹, 杜鸿飞, 张佳佳. 石家庄地区16 490例过敏患儿过敏原分布特征分析[J]. 河北医科大学学报, 2022, 43(3): 345-349.
[5]	吴会芳, 张景丽, 刘晓娟, 吴晓杰, 段晨初, 张中平. HMGB1、GM-CSF、LDH在慢性肺炎患儿中的表达及相关性研究 [J]. 河北医科大学学报, 2022, 43(10): 1158-1162.
[6]	温婵, 张丽霞, 孙玲. 2011-2019年河北某儿童医院耐甲氧西林金黄色葡萄球菌分布特点及耐药性变迁[J]. 河北医科大学学报, 2022, 43(1): 84-87.
[7]	赵宁, 贺新建, 李易明. 超声心动图改善儿童PICC尖端右心异位的评估研究[J]. 河北医科大学学报, 2021, 42(5): 592-596.
[8]	周辉, 仲智勇. 一种儿童完全植入式静脉输液港尖端定位中的新型方法及应用[J]. 河北医科大学学报, 2021, 42(5): 603-606.
[9]	白磊鹏, 吕家兴, 王瑜, 孔庆柱, 金宇, 赵景新. 经皮穿针联合外固定架微创治疗大龄儿童肱骨近端骨折的效果分析[J]. 河北医科大学学报, 2021, 42(4): 420-424.
[10]	谷海飞, 李超, 张明, 杜文康. 肺保护性通气策略联合不同剂量顺式阿曲库铵对小儿日间腹腔镜手术的影响[J]. 河北医科大学学报, 2021, 42(2): 231-234.
[11]	郑芳, 卞相丽, 李妙晨, 吴志敏. 沙美特罗替卡松气雾剂联合粉尘螨滴剂舌下免疫治疗尘螨过敏性哮喘的临床效果[J]. 河北医科大学学报, 2021, 42(10): 1180-1184.
[12]	赵汝莲，王阳，皮练鸿*. 儿童轻度过敏性结膜炎中干眼的研究及治疗[J]. 河北医科大学学报, 2020, 41(9): 1065-1069.
[13]	弭莉1，杜潘艳2. 儿童支原体肺炎急性期2种检测方法的比较及意义#br#[J]. 河北医科大学学报, 2020, 41(7): 834-837.
[14]	齐文辉，王忠义，徐志杰，苗国瑞. 麻醉诱导前视听干预对学龄前患儿术后行为异常的影响[J]. 河北医科大学学报, 2020, 41(2): 235-238.
[15]	阎雪1，皮亚雷1，张亚男1，崇禾萌1，张会丰1*，吴志焕2. Wililams-Beuren综合征病例分析#br#[J]. 河北医科大学学报, 2020, 41(2): 241-245.

家庄市汉族初诊Graves病儿童25羟维生素D状况分析

Analysis of 25 hydroxyvitamin D status in newly diagnosed Han children with Graves disease in Shijiazhuang city#br#

HTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价