银屑病患者血脂及空腹血糖的临床特征分析#br#

doi:10.3969/j.issn.10073205.2019.08.012

河北医科大学学报

银屑病患者血脂及空腹血糖的临床特征分析#br#

1.西安交通大学医学院第一附属医院检验科，陕西西安 710061；2.西安交通大学医学院第一附属医院皮肤科，
陕西西安 710061；3.西安交通大学医学院第一附属医院转化医学中心，陕西西安 710061

出版日期:2019-08-25 发布日期:2019-08-14
作者简介:汪靖园（1983-），女，陕西宝鸡人，西安交通大学医学院第一附属医院主管检验师，医学硕士，从事临床检验学研究。
基金资助:
国家自然科学基金青年科学基金项目（81703130）；陕西省社会发展科技攻关项目（2016SF238）；陕西省自然科学基础研究计划（2017JM8121）

Analysis of clinical features of serum lipid and fasting bloodglucose in the patients with psoriasis

1.Department of Clinical laboratory, the First Affiliated Hospital of Xi′an Jiaotong University, Xi′an
710061, China； 2.Department of Dermatology, the First Affiliated Hospital of Xi′an Jiaotong
University, Xi′an 710061, China； 3.Center for Translational Medicine, the First Affiliated
Hospital of Xi′an Jiaotong University, Xi′an 710061, China

Online:2019-08-25 Published:2019-08-14

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗分析银屑病患者血脂及血糖代谢的特点。
〖HTH〗方法〖HTSS〗〖KG*2〗回顾性分析268例银屑病患者及298例健康对照者的总胆固醇（total cholesterol,TC）、三酰甘油（triglyceride,TG）、高密度脂蛋白胆固醇（highdensity lipoprotein cholesterol,HDLC）、低密度脂蛋白胆固醇（lowdensity lipoprotein cholesterol,LDLC）和空腹血糖（fasting plasma glucose,FPG），并比较血脂、血糖在不同性别、年龄和银屑病类型的差异。
〖HTH〗结果〖HTSS〗〖KG*2〗银屑病组TC、 TG、 LDLC和FBG水平均高于正常对照组，HDLC水平低于正常对照组（P＜005）；男性银屑病患者HDLC水平低于女性（P＜005），而TC、TG、LDLC和FBG水平差异均无统计学意义（P＞005）。银屑病40～49岁组、50～59岁组TC水平高于＜30岁组，50～59岁组TC水平高于30～39岁组（P＜005）；≥70岁组TG水平低于其他各年龄组（P＜005）；40～49岁组、50～59岁组HDLC水平高于＜30岁组，50～59岁组HDLC水平高于30～39岁组，≥70岁组HDLC水平低于其他各年龄组（P＜005）；40～49岁组、50～59岁组LDLC水平高于≤30岁组，≥70岁组LDLC水平低于其他各年龄组（P＜005）；各年龄组间FBG水平差异均无统计学意义（P＞005）。红皮型银屑病患者TC和LDLC水平高于脓疱型、关节型和寻常型（P＜005）,TG、HDLC和FBG水平在各型间差异均无统计学意义（P＞005）。
〖HTH〗结论〖HTSS〗〖KG*2〗银屑病患者存在脂质及糖类代谢异常。高脂血症发病率很高，其中HDLC与性别有关，TC、HDLC和LDLC与年龄有关，红皮病型更易罹患高脂血症。

关键词: 银屑病, 血脂异常, 葡萄糖代谢障碍

Abstract: ［Abstract］ Objective〖HTSS〗〓To analyze the clinical feature of lipid metabolism and glucose metabolism in the patients with psoriasis.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The total cholesterol(TC), triglycerides(TG), highdensity lipoprotein cholesterol(HDLC), lowdensity lipoprotein cholesterol(LDLC) and fasting plasma glucose(FPG) of 268 psoriasis patients and 298 healthy controls were analyzed retrospectively and compared in different genders, ages and psoriasis types.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Compared with healthy controls,the serum levels of TC, TG, LDLC and FPG were significantly higher, while the levels of HDLC were significantly lower in patients with psoriasis(〖WTBX〗P〖WT〗＜005). HDLC levels in male patients with psoriasis were significantly lower than those in female patients(P＜005). But there were not significant differences of serum TC, TG, LDLC and FPG between males and females(P＞005). TC in the agebracket 40-49 and 50-59 were higher than those in group under 30 years old, and TC in agebracket 50-59 were higher than those in 30-39 years old. TG in group over 70 years old were lower than those in other age groups; HDLC in the agebracket 40-49 and 50-59 were higher than those in group under 30 years old; HDLC in the agebracket 50-59 were higher than those in 30-39; HDLC in the group over 70 years old was lower than those in other age groups(P＜005). LDLC in the agebracket 40-49 and 50-59 were higher than those in group under 30 years old, while LDLC in the group over 70 years oldwere lower than those in other age groups(P＜005). There were no statistically significant differences in FBG among all age groups(P＞005).TC and LDLC levels in erythrodermic psoriasis were significantly higher than those in other types of psoriatic patients(P＜005). However, there were no significance in TG, HDLC and FPG levels among different types(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Abnormal lipid and glucose metabolism can be observed in psoriasis patients. The incidence of hyperlipidemia is very high. Additionally, HDLC is related to gender, while TC, HDLC and LDLC are related to age. The patients with erythroderma psoriasis are more susceptible to hyperlipidemia.

Key words: psoriasis, dyslipidemias, glucose metabolism disorders

汪靖园1，韩〓丹2，许〓鑫1，王〓博3，王丽娟2，周〓艳2*. 银屑病患者血脂及空腹血糖的临床特征分析#br#[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2019.08.012.

WANG Jingyuan1, HAN Dan2, XU Xin1, WANG Bo3, WANG Lijuan2, ZHOU Yan2*. Analysis of clinical features of serum lipid and fasting bloodglucose in the patients with psoriasis[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2019.08.012.

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银屑病患者血脂及空腹血糖的临床特征分析#br#

Analysis of clinical features of serum lipid and fasting bloodglucose in the patients with psoriasis

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