河北医科大学学报 ›› 2021, Vol. 42 ›› Issue (2): 181-185.doi: 10.3969/j.issn.1007-3205.2021.02.013

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影响中心性浆液性脉络膜视网膜病变患者复发的相关因素

  

  1. 辽宁省辽阳市中心医院眼科，辽宁 辽阳 111000
  • 出版日期:2021-02-25 发布日期:2021-03-09
  • 作者简介:宋清雪（1980-），女，辽宁丹东人，辽宁省辽阳市中心医院副主任医师，医学硕士，从事眼底病诊治研究。
  • 基金资助:
    辽宁省自然科学基金项目(201802031)

Related factors influencing recurrence in patients with central serous chorizoretinopathy

  1. Department of Ophthalmology， Central Hospital of Liaoyang， Liaoning Province， Liaoyang 111000, China
  • Online:2021-02-25 Published:2021-03-09

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摘要： 目的  探究影响中心性浆液性脉络膜视网膜病变（central serous chorizoretinopathy，CSC）患者复发的相关因素。
方法  选取我院收治诊断为CSC患者90例。入院对所有患者进行眼底荧光血管造影检查（fundus fluorescence angiography，FFA）和视力检查，治疗后随访6个月，对患者的视力功能进行复查及眼底造影复查，根据复发情况，将其分为复发组（n=30）、非复发组（n=60）。通过单因素分析、多因素Logistic 回归分析影响CSC患者复发的独立危险因素，通过Spearman 相关分析法分析危险因素与CSC复发的相关性。运用受试者工作特征（receiver operating characteristics，ROC）曲线下面积（area under curve，AUC）分析危险因素对CSC患者复发的评估价值。
结果  单因素分析结果显示，2组病程、渗漏类型、渗漏面积、渗漏点距离比较差异有统计学意义（P＜0.05）。多因素Logistic 回归分析结果显示，病程、渗漏类型、渗漏面积、渗漏点距离是影响CSC患者复发的独立危险因素（P＜0.05）。Spearman 相关分析结果显示，病程、渗漏类型、渗漏面积、渗漏点距离与CSC复发存在线性正相关关系（P＜0.05）。病程、渗漏类型、渗漏面积、渗漏点距离联合指标评估CSC患者复发的特异度（89.87%）、敏感度（87.91%）、AUC（0.895）均显著高于单一指标（P＜0.05）。
结论  影响CSC患者复发的相关因素较多，病程、渗漏类型、渗漏面积、渗漏点距离是影响CSC患者复发的独立危险因素。


关键词: 中心性浆液性脉络膜视网膜病变, 复发, 相关因素

Abstract: Objective  To explore the related factors affecting recurrence in patients with central serous chorizoretinopathy(CSC).
Methods  A total of 90 patients with CSC admitted to our hospital were selected. All patients were hospitalized for fundus fluorescence angiography(FFA) and visual acuity examination. Patients were followed up for 6 months after treatment for visual function review and fundus angiography review. Patients were divided into a recurrent group(n=30) and a non-recurrent group(n=60) according to their recurrence.Univariate analysis and multivariate Logistic regression analysis were used to analyze the independent risk factors affecting CSC patients recurrence, and Spearman correlation analysis was used to analyze the correlation between risk factors and CSC recurrence. The area under the receiver operating characteristics(ROC) curve(AUC) was used to analyze the evaluation value of risk factors for CSC patients recurrence. 
Results  Univariate analysis showed that there were significant differences between two groups in course of disease, type of leakage, leakage area and distance of leakage points(P＜0.05). The results of multivariate Logistic regression analysis showed that course of disease, type of leakage, leakage area and distance of leakage points were independent risk factors for recurrence in CSC patients(P＜0.05). Spearman correlation analysis showed that the course of disease, type of leakage, leakage area and distance of leakage points were in a linearpositive correlation with CSC recurrence(P＜0.05). The specificity(89.87%), sensitivity(87.91%) and AUC(0.895) of the combined indicators of the course of disease, type of leakage, leakage area and distance of leakage points in CSC patients were significantly higher than those of the single indicator(P＜0.05). 
Conclusion  There are many related factors affecting CSC patients′ recurrence. The course of disease, type of leakage, leakage area and distance of leakage points are independent risk factors affecting CSC patients recurrence.

Key words: central serous chorizoretinopathy, recurrence, relative factors

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