关键词: 糖尿病, 妊娠, 低血糖症, 果糖胺, 晚期糖基化终末产物

Abstract: Objective To explore the correlation between the levels of fructosamine (FTM), advanced glycation end products (AGE) and neonatal hypoglycemia in pregnant women with gestational diabetes mellitus (GDM). 
Methods A total of 94 pregnant women with GDM were selected. According to presence of hypoglycemia in the newborns, they were divided into hypoglycemia group (n=53) and normal blood glucose group (n=41). Clinical data, FTM and AGE levels of the two groups were compared. Pearson correlation analysis was conducted to analyze the relationship between FTM and AGE levels with fasting blood glucose (FBG) level and 2 h postprandial blood glucose (2 hPG) level. Risk factors of neonatal hypoglycemia were analyzed, and ROC curve was drawn to analyze the predictive value of FTM and AGE level for neonatal hypoglycemia. 
Results The birth weight of newborns in the hypoglycemia group was lower than that in the normal blood glucose group, and the proportion of premature infants, maternal body mass index, FBG, 2hPG, FTM and AGE levels were higher than those in the normal blood glucose group, with statistical significance (P＜0.05). Pearson correlation analysis showed that FTM and AGE levels were positively correlated with FBG and 2 hPG levels (P＜0.05). Logistic regression analysis showed that high FTM and AGE level were risk factors for neonatal hypoglycemia (P＜0.05). The area under the curve (AUC) value of FTM and AGE levels in combination in predicting neonatal hypoglycemia was higher than that by single factor detection (P＜0.05). 
Conclusion The overexpression of FTM and AGE in cord blood of pregnant women with GDM is a risk factor for neonatal hypoglycemia, which can effectively predict the risk of neonatal hypoglycemia and provide theoretical reference for clinical prevention and treatment. 

Key words: diabetes, gestational, hypoglycemia, fructosamine, advanced glycation end products