卵巢上皮性肿瘤患者超声造影定量参数检测意义

doi:10.3969/j.issn.1007-3205.2024.03.007

摘要/Abstract

摘要： 目的探讨超声造影定量参数在卵巢上皮性肿瘤鉴别诊断中的应用及与恶性转化中新生血管形成的相关性。
方法选取卵巢上皮性肿瘤患者102例，分为恶性组51例，良性组51例。收集2组超声造影参数，采用受试者工作特征（receiver operating characteristiccurve，ROC）曲线分析超声造影参数对卵巢上皮性肿瘤的鉴别诊断价值，Logistic回归分析超声造影参数与卵巢上皮性肿瘤恶性发病关系，相关性分析恶性组超声造影参数、微血管密度（microvessel density，MVD）与国际妇产科联盟（Inter-national Federation of Gynecology and Obstetnics,FIGO)分期、分化程度、淋巴结转移的关系及恶性组超声造影参数与MVD关系。
结果恶性组始增时间、达峰时间低于良性组，峰值强度、增强速率、时间-强度曲线下面积高于良性组（P＜0.05）；各超声造影参数联合诊断的卵巢上皮性肿瘤的AUC大于单独诊断（P＜0.05）；Logistic回归结果显示，始增时间、达峰时间、峰值强度、增强速率及时间-强度曲线下面积均与卵巢上皮性癌发病有关（P＜0.05）；恶性组始增时间、达峰时间与FIGO分期、淋巴结转移呈负相关，与分化程度呈正相关，峰值强度、增强速率、时间-强度曲线下面积、MVD与FIGO分期、淋巴结转移呈正相关，与分化程度呈负相关（P＜0.05）；恶性组始增时间、达峰时间与MVD呈负相关，PI、增强速率、时间-强度曲线下面积与MVD呈正相关（P＜0.05）。
结论超声造影定量参数对卵巢上皮性肿瘤鉴别具有一定诊断价值，且恶性肿瘤患者与FIGO分期、淋巴结转移、分化程度、新血管形成密切相关，可为临床鉴别卵巢上皮性肿瘤提供参考。

关键词: 卵巢肿瘤, 超声造影, 定量参数

Abstract: Objective To investigate the application of contrast-enhanced ultrasound (CEUS) quantitative parameters in differential diagnosis of ovarian epithelial tumors and its correlation with neovascularization in malignant transformation.
Methods In total, 102 patients with ovarian epithelial tumors were selected and divided into malignant group (n=51) and benign group (n=51). CEUS parameters of the two groups were collected, and receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic value of CEUS parameters for the differential diagnosis of ovarian epithelial tumors. Logistic regression analysis was used to investigate the relationship between CEUS parameters and the incidence of ovarian epithelial cancer. Correlation analysis was used to investigate the relationship between CEUS parameters, microvascular density (MVD), International Federation of Gynecology and Obstetrics(FIGO) stage, differentiation degree, and lymph node metastasis in the malignant group, as well as the relationship between CEUS parameters and MVD in the malignant group.
Results The initial increase time and peak time in the malignant group were lower than those in the benign group, while the peak intensity, enhancement rate, and area under the time-intensity curve were higher than those in the benign group(P＜0.05). The area under the ROC curve (AUC) of various CEUS parameters in combination in diagnosing ovarian epithelial tumors was greater than that of each parameter alone (P＜0.05). Logistic regression results showed that the initial increase time, peak time, peak intensity, enhancement rate, and area under the time-intensity curve were all associated with the development of ovarian epithelial cancer (P＜0.05).The initial increase time, peak time in the malignant group were negatively correlated with FIGO stage and lymph node metastasis, and positively correlated with differentiation degree, while peak intensity, enhancement rate, area under the time-intensity curve, and MVD were positively correlated with FIGO stage and lymph node metastasis, and negatively correlated with differentiation degree (P＜0.05). The initial increase time, peak time in the malignant group were negatively correlated with MVD, while PI, enhancement rate, and area under the time-intensity curve were positively correlated with MVD (P＜0.05).
Conclusion CEUS quantitative parameters have certain diagnostic value in the identification of ovarian epithelial tumors, and malignant tumors in patients are closely related to FIGO stage, lymph node metastasis, degree of differentiation, and neovascularization, which can provide reference for clinical identification of ovarian epithelial tumors.

Key words: ovarian neoplasms, contrast-enhanced ultrasound, quantitative parameter

江雪清, 李晓庆, 李晓桐, 程蔚然. 卵巢上皮性肿瘤患者超声造影定量参数检测意义[J]. 河北医科大学学报, 2024, 45(3): 289-295.

JIANG Xue-qing, LI Xiao-qing, LI Xiao-tong, CHENG Wei-ran. Significance of detection of contrast-enhanced ultrasound quantitative parameter in patients with ovarian epithelial tumors [J]. Journal of Hebei Medical University, 2024, 45(3): 289-295.

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卵巢上皮性肿瘤患者超声造影定量参数检测意义

Significance of detection of contrast-enhanced ultrasound quantitative parameter in patients with ovarian epithelial tumors

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