关键词: 卵巢肿瘤, CRIP1, 表达

Abstract: Objective  To analyze the expression level and clinical significance of cysteine-rich intestinal protein 1(CRIP1) gene in ovarian cancer via bioinformatics methods. 
Methods  Oncomine database was used to analyze the expression level of CRIP1 gene in different types of tumors and pathological types of ovarian cancers.Kaplan-Meier Plotter tool was employed to analyze the relationship between high and low expression of CRIP1 gene and prognosis of ovarian cancer patients. STRING database and GEPIA database were retrieved to analyze CRIP1- interacting proteins in ovarian cancer. 
Results  CRIP1 gene was found to be differentially expressed in various types of tumors(P＜0.05), but highly expressed in ovarian cancer tissue. Combined with clinical characteristics, overall survival(OS) and progression-free survival of ovarian cancer patients with the high expression of CRIP1 gene were significantly reduced, and the patients with CRIP1 high expression had a poor OS after chemotherapy with Paclitaxel, Docetaxel or Topotecan. The interaction network diagram of CRIP1 was constructed, and CRIP1 was negatively correlated with STK4 and YAP1, while positively correlated with LGALS3 and ATOX1 in ovarian cancer. Moreover, go clustering analysis showed that CRIP1 was involved in various biological pathways. 
Conclusion  CRIP1 gene could be a significant target for the diagnosis and treatment, as well as a key indicator for the prognosis in ovarian cancer patients. 

Key words: ovarian neoplasms, CRIP1, expression