Diagnostic value of pulmonary infection score, calcitonin and C reactive protein in patients with idiopathic pulmonary fibrosis complicated with infection

doi:10.3969/j.issn.10073205.2016.07.010

Abstract

Abstract: [ Abstract ] Objective To explorethe diagnosticsignificance , correlation and clinical
diagnosisvalueofthesimplifiedclinicalpulmonaryinfectionscore ( CPIS ), procalcitonin ( PCT )
andC-reactiveprotein ( CRP ) inidiopathicpulmonaryfibrosis ( IPF ) complicatedwithpulmonary
bacterialinfection.Methods Atotalof98adultpatients , whowereclinicallydiagnosedasIPF
complicatedwithpulmonarybacterialinfection , wereenrolledinthisprospectivediagnostictest ,
monitoringvariousinflammatoryindicatorssuchasCRP , PCT , calculatingthesimplifiedCPIS
onthefirstdayoftheadmission.Thesensitivity , specificity , accuracyofPCT , CRPandCPIS
forthediagnosisofIPFcombinedwithpulmonarybacterialinfectionswerecalculatedafterthe
experiment.Results Thesensitivity , specificityandaccuracyofPCTandCPISinthediagnosis
ofIPFwithpulmonaryinfectionwashigherthanthatofCRP.Thespecificityandaccuracyof
PCTcombinedwithsimplifiedCPISindiagnosisofIPFwithpulmonaryinfectionwashigherthan
thatofCPISandPCT , butthesensitivitywasnotimproved.ThePCTandCPISwerepositively
correlatedwiththeconventionalinflammatorymarkers ( r =0.450 , P =0. 000 ) .Conclusion The
simplified CPIScombined with PCT detection washelpfultoimprovetheearly diagnostic
specificityofIPFcomplicated withpulmonarybacterialinfection , andthesensitivitywasnot
improved.

Key words: pulmonary fibrosis, bacterial infections, Creactive protein, procalcitonin

WANG Jun, REN Ruihua, GAO Yong*， HOU Hongwei, WANG Liang, SUN Jinhao. Diagnostic value of pulmonary infection score, calcitonin and C reactive protein in patients with idiopathic pulmonary fibrosis complicated with infection[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2016.07.010.

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Diagnostic value of pulmonary infection score, calcitonin and C reactive protein in patients with idiopathic pulmonary fibrosis complicated with infection

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