Abstract: Abstract］ ObjectiveTo evaluate the effect of platelet glycoprotein Ⅱb/Ⅲa receptor blockade on platelet function and myocardial perfusion in patients with acute nonST segment elevation myocardial infarction(NSTEMI) complicated with type 2 diabetes mellitus(T2DM) treated by percutaneous coronary intervention(PCI).  MethodsA total of 115 patients with STEMI and T2DM were randomized assigned to receive either tirofiban and PCI(n=59) or PCI alone(n=56). The maximum platelet aggregation rate(MPAR) were measured in all patients. Trombolysis in myocardial infarction grade and the myocardial perfusion grade(MPG) were studied immediately after PCI. ResultsAt different time points in the application of tirofiban, MPAR in tirofiban group were much lower than those of control group（P＜001）. The proportion of MPG in tirofiban group was significantly higher than that in the control group(P＜001). There was no significant difference in bleeding complications between 2 groups.  ConclusionTirofiban can effectively inhibit platelet aggregation in patients with NSTEMI complicated with T2DM, improve postoperative myocardial perfusion with clinical safety and feasibility.

Key words: myocardial infarction, diabetes mellitus, type 2, treatment outcome