Abstract: ［Abstract］ Objective To observe the efficacy of laparoscopic uterine artery occlusion plus uterine adenomyectomy combined with Mirena on uterine adenomyoma and its effect on ovarian function.
Methods One hundred and thirty patients with adenomyoma were randomly divided into observation group and control group, 65 cases in each group. The control group was given Mifepristone, and the observation group was treated with Mirena. The clinical efficacy and total effective rate were observed in two groups. The uterus volume, uterine cavity size and carbohydrate antigen 125（CA125） were compared between two groups. The menstrual and ovarian function was compared before and after treatment, and the incidence of adverse reactions was compared between two groups.
Results The clinical efficacy and total effective rate in observation group were higher than those in control group(P＜0.05). The uterus volume, uterine cavity size and CA125 level in two groups were significantly smaller and lower than those before treatment(P＜0.05), and the reduction and reduction in the observation group was more obvious. After treatment, the uterus volume, uterine cavity size and CA125 level in observation group were lower than those in control group(P＜0.05). After treatment, the menstrual period was significantly shortened, the pain score was significantly lower, and the menstrual cycle was significantly longer than that before treatment(P＜0.05). After treatment the pain score in observation group was lower than that of the control group(P＜0.05), the levels of luteinizing hormone（LH） and follicle-stimulating hormone（FSH） in two groups were significantly lower than those before treatment, and the estradiol（E2） level was significantly higher than that before treatment(P＜0.05). The levels of LH, FSH and E2 in the observation group were lower than those in control group(P＜0.05). There was no significant difference in the incidence of adverse reactions between two groups(P＞0.05).
Conclusion Laparoscopic uterine artery occlusion plus resection of adenomyoma combined with Mirena is effective in treating adenomyoma of the uterus, which can significantly relieve symptoms and improve the body′s sex hormone disorder.

Key words: adenomyoma of uterus, laparoscopy, ovarian function, dysmenorrhea