Abstract: Objective  To investigate the risk factors related to contrast -induced nephropathy(CIN) in endovascular surgery.
Methods  The clinical data of 279 patients who underwent endovascular surgery were retrospectively analyzed. According to the changes of renal function before and after endovascular treatment, they were divided into CIN group and non-CIN group. The gender, age, weight, comorbidities(hypertension, diabetes, coronary heart disease), major diagnosis, type and dose of contrast, preoperative renal function, and excessive use of contrast compared, and the risk factors for CIN in endovascular treatment were analyzed.
Results  There were 37 cases(13.3%) of CIN in 279 patients during endovascular treatment, and 3 cases required temporary hemodialysis treatment. The univariate analysis showed significant difference between two groups with respect to gender, major diagnosis, type and dose of contrast, preoperative renal function, and excessive use of contrast(P＜0.05). Multivariate regression analysis showed that the excessive use of contrast was a risk factor for CIN after endovascular treatment(P＜0.05).
Conclusion  Excessive use of contrast is an independent risk factor for CIN in endovascular treatment, and the risk of disease onset is 3.8 times that of non-overdose users. The maximal acceptable contrast dose should be calculated individually before surgery to avoid over-use, and preventive measures should be taken more actively for patients with overdose.

Key words: vascular surgery, endovascular treatment, contrast-induced nephropathy, risk factor