Abstract: Objective  To evaluate the nutritional risk of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) and its predictive value on prognosis. 
Methods  A total of 86 AECOPD patients were selected as AECOPD group, and 60 patients with stable COPD and 60 healthy people were selected as stable COPD group and control group respectively. Nutrition Risk Screening 2002(NRS 2002) was used for nutritional risk assessment, and the patients were divided into non-nutritional risk patients with 0-2 points and nutritional risk patients with 3-7 points.The prognosis was assessed according to the 28-day survival of AECOPD patients. Kaplan Meier curve was used to analyze the difference of prognosis, ROC curve was used to analyze the predictive value of NRS 2002 score on prognosis, and Logistic regression model was used to analyze the influencing factors of prognosis. 
Results  The NRS 2002 score and the proportion of nutritional risk in AECOPD group were higher than those in stable COPD group and control group(P＜0.05). Kaplan Meier curve analysis showed that the 28-day cumulative survival rate of patients with nutritional risk in AECOPD group was lower than that in patients without nutritional risk(P＜0.05). ROC curve analysis showed that NRS2002 score had predictive value for 28-day survival of AECOPD patients(P＜0.05). Logistic regression analysis showed that age, ALB, multi-drug resistance, APACHE Ⅱ score and nutritional risk were the influencing factors of prognosis of AECOPD patients(P＜0.05). 
Conclusion  Nutritional risk is related to the severity and 28-day prognosis of AECOPD patients. Targeted reduction of nutritional risk may help improve the prognosis of AECOPD.

Key words: pulmonary disease, chronic obstructive, nutritional risk, prognosis