Abstract: Objective To study the effect of niergoline combined with indobuprofen in the treatment of acute cerebral infarction (ACI). 
Methods A total of 122 patients with ACI admitted to the First Affiliated Hospital of Huaian were selected and divided into research group (n=61) and control group (n=61) by random number table method. Both groups received basic treatment, the control group was additionally given indobuprofen, and the research group was additionally given niergoline. Both groups were treated for 14 d. National Institute of Health Stroke Scale (NIHSS) score, Modified Rankin Scale (mRS) score, clinical efficacy, serum levels of heart-type fatty acid-binding protein (H-FABP), β-actin (β-actin), insulin-like growth factor-1 (IGF-1), plasma specific viscosity, whole blood high shear viscosity, plasma fibrinogen, whole blood low shear viscosity and safety of the two groups were compared. 
Results After treatment, both groups showed a decrease in NIHSS scores and mRS scores, with the research group being lower than the control group (P＜0.05). The total effective rate of the research group (91.80%) was higher than that of the control group (77.05%) (P＜0.05). After treatment, the levels of serum H-FABP and β-actin in both groups decreased, with the research group being lower than the control group (P＜0.05). After treatment, the serum IGF-1 levels in both groups increased, with the research group being higher than the control group (P＜0.05). After treatment, both groups showed a decrease in plasma specific viscosity, whole blood high shear viscosity, plasma fibrinogen, and whole blood low shear viscosity, with the research group being lower than the control group (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). 
Conclusion Niergoline combined with indobuprofen is effective in the treatment of ACI, and can improve the neurological function, serum biochemical indexes and hemorheology, and has few adverse reactions. 

Key words: brain infarction, nicergoline, indobuprofen