Abstract: ［Abstract］ Objective〖HTSS〗〓To analyze the relationship between the changes of intracranial pressure in patients with massive acute cerebral infarction and the changes of serum neuron specific enolase neuronspecific enolase（NSE） and S100B protein.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Thirty patients with large area cerebral infarction who met the criteria were selected, and noninvasive intracranial pressure monitor was used to monitor intracranial pressure. Dynamic monitoring of intracranial pressure was performed on patients who met the criteria within 24 h after admission, 3 days after onset, 5 days after onset, and 7 days after onset. The application of enzyme linked immunosorbent assay in monitoring the protein level of S100B protein and serum NSE, and compared with 30 healthy people(control group), the serum level of NSE and S100B protein subtype and the intracranial pressure were made for the content correlation analysis.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The intracranial pressure, specific enolase and serum S100B protein in the case group were significantly higher than those in the control group within 24 h after onset. The difference was statistically significant(P＜005). In the case group,after the onset of 3 d, 5 d, 7 d of the intracranial pressure, the specific enolase and serum S100B protein were higher than the admission of 24 h, and began to decline on the 7 days after admission, but still higher than admission for 24 h.The difference was statistically significant(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The changes of intracranial pressure in patients with massive cerebral infarction accompanied by changes in serum NSE and S100B protein levels can reflect the changes of intracranial pressure indirectly by measuring the changes of serum NSE and S100B protein levels，expecting to become a certain reference value for clinical evaluation of the severity and prognosis of the disease.

Key words: brain infarction, intracranial pressure, 2phosphoDglycerate hydrolase, S100B protein