Abstract: ［Abstract］  Objective〖HTSS〗〓To discuss the effect of intensive atorvastatin before operation combined with full hydration therapy on contrast induced nephropathy(CIN) in patients after percutaneous coronary intervention(PCI) .
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Ninetytwo cases of patients with coronary heart disease undergoing elective PCI surgery treated in our hospital were randomly divided into intensive group and conventional group, with 46 cases in either group. The intensive group were given intensive atorvastatin before operation combined with full hydration therapy, while the conventional group were given conventional atorvastatin combined with full hydration therapy. The changes of levels of serum creatinine(SCr),blood urea nitrogen(BUN) and urinary β2microglobulin(β2MG) at different moments and the incidence rates of CIN were compared between the two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The levels of SCr, BUN and β2MG in the intensive group and the conventional group showed a trend of increasing first and then decreasing with the time extension. The change range of the intensive group was smaller, There were significant differences between the two groups、time point and effect each other(P＜005). There was no significant difference in the incidence of CIN between the two groups(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The intensive atorvastatin before operation combined with full hydration therapy protect the renal function of patients undergoing PCI surgery.

Key words: nephrosis, percutaneous coronary intervention, atorvastatin