Abstract: ［Abstract］〓Objective〖HTSS〗〓To investigate the effect of sevelamer combined with elcatonin on the efficacy of hyperphosphatemia in hemodialysis patients.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 103 patients with hemodialysis hyperphosphatemia  were divided into sevelamer group(34 cases), elcatonin group(34 cases) and combined group(35 cases) according to random number table. The patients in sevelamer group were po administered with sevelamer carbonate tablets, 800 mg/times, 3 times daily. The patients in elcatonin group received intramuscular injection of elcatonin injection, 1 mL/times, once a week. The patients in the combined group were treated with sevelamer carbonate and elcatonin, and the method of administration is the same as the two single drug groups. All three groups were treated for 12 weeks. Observe and compare the clinical efficacy of each group.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The clinical efficacy of the sevelamer group was superior to that of the elcatonin group. The combined clinical efficacy was better than the sevelamer group and the elcatonin group(P＜005). The total effective rate in the sevelamer group was significantly higher than that in the elcatonin group; the total effective rate in the combined group was higher than that of the sevelamer group and elcatonin group, the difference was statistically significant(P＜005). After treatment, serum phosphorus, calciumphosphorus product, intact parathyroid hormone(iPTH), highsensitivity Creactive protein(hsCRP), and fibroblast growth factor 23(FGF23) levels were significantly decreased in each group, the serum calcium levels in the combined group and the elcatonin group were significantly lower than before treatment(P＜00.05). Compared with the elcatonin group, the serum phosphorus, calciumphosphorus product, iPTH, hsCRP, and FGF23 levels decreased more significantly in the sevelamer group(P＜005). The changes of the above indicators in the combined group were significantly higher than those in the sevelamer group and the elcatonin group(P＜005). There was no significant difference in the incidence of adverse reactions between the three groups(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Both sevelamer and elcatonin are effective in lowering blood phosphorus, but sevelamer is more effective than elcatonin. Sevelamer and elcatonin have the best effect of controlling serum phosphorus, which can effectively improve the quality of life of patients and has certain clinical promotion value.

Key words: renal dialysis, hyperphosphatemia, sevelamer, elcatonin