Abstract: Objective To analyze the impact of clinical condition, examination and laboratory results,especially cardiac valve calcification, on mortality of patients undergoing maintenance hemodialysis in our center in the past three years. 
Methods A total of 443 patients undergoing hemodialysis in our hospital were analyzed. The first recorded data and clinical findings of dead and alive patients were compared. 
Results Among all patients, 298 patients survived and 145 died. Dead patients had an older mean age, 60% of dead patients had coronary heart disease, and 53.8% had cardiac valve calcification. The duration of hemodialysis was shorter in dead patients. Alkaline phosphatase,albumin,urea clearance index(Kt/V)were lower, while C-reactive protein,full-length parathyroid hormone and the potassium level before hemodialysis were higher in dead patients.Logistic regression analysis showed that age, coronary artery disease(CAD)and multiple cardiac valve calcification(≥2) were independent risk factors for mortality. Potassium level before hemodialysis, full-length parathyroid hormone and higher Kt/V were conductive to survival. 
Conclusion Age, CAD and multiple cardiac valve calcification are risk factors for mortality of patients undergoing maintenance hemodialysis.

Key words: renal dialysis, heart valve diseases, mortality