Abstract: Objective To observe the change of serum and urine biochemical indexes in kidney damage rats with severe acute pancreatitis (SAP).Methods A total of 240 healthy male Sprague-Dawley rats were selected as the research obj ects,and the rats were randomly divided into eight groups (each group,n=30)by random number table,named as SAP different time group (SAP 1h,3h,6h,9h,12h,18h,24h group)and the control group.The serum amylase (AMY),serum creatinine (SCr),blood urea nitrogen (BUN)and blood uric acid (UA),the urine creatinine (UCr),renal injury molecules (KIM)-1 andβ-N-acetyl amino glycosidase enzymes (NAG)of different groups were compared.Results The levels of SCr,BUN and UA of SAP 1h, 3h,6h,9h,12h,18h,24h group were higher than those of the control group,the differences were statistically significant (P<0.05).The UCr levels of SAP 1h,3h,6h,9h,12h group were lower than those of the control group,the levels of KIM-1 and NAG were higher than those of the control group,the differences were statistically significant (P<0.05).Conclusion In SAP kidney damage,the renal tubular inj ury is earlier than the capillary damage.The KIM-1 and NAG are the renal tubular damage j udge indexes,the sensitivity and specificity were better than Cr,BUN and UA for early diagnosis of SAP kidney damage.

Key words: pancreatitis, acute necrotizing, acute kidney inj ury, biological markers