Abstract: Objective To explore the clinical features and treatment methods of isolated coronary artery ectasia ( CAE ) at high altitude by coronary arteriography. Methods Coronary arteriographic images and clinical data of 912 cases from high altitude( 2 260 - 4 500 m ) were retrospectively analyzed. Results Thirty-two isolated CAE cases were found in 912 coronary arteriographic populations with the incidence of 3. 5%. Right coronary artery(26 cases,41. 3%),left main coronary artery(17 cases,27%),anterior descending branch(13 cases,20. 6%)and circumflex(7 cases,11. 1% ) were the predilection sites in turn. Hyperlipidemia,drinking,hypertension, hyperglycemia,altitude and hemoglobinre were the independent risk factors of isolated CAE. Eight cases had still had angina in the half year of follow-up. Conclusion Except the risk factors with coronary heart disease,altitude hypoxia is another factor of isolated CAE. Antiplatelet drugs,calcium antagonists,statins and trimetazidine need long time use for the patients. CAE drug or intervention in high-risk patients who can not control the need for surgical ligation or resection of hemangioma,at the same time the need for bypass operation of coronary artery.

Key words: coronary artery disease, altitude, risk factors