Abstract: Objective To explore effective treatments for patients with obesity hypoventilation syndrome complicated by heart failure. Methods Retrospective analysis was performed on 120 patients with obesity hypoventilation syndrome complicated by heart failure. Noninvasive positive pressure ventilation( NPPV)group(60 cases)was treated with NPPV and medications,and the control group(60 cases)only with medications. The related indicators and curative effects before treatment,6 months after treatment were compared between two groups. Results Arterial blood gas analysis,brain natriuretic peptide( BNP ),echocardiography and polysomnography( PSG ) the control group after treatment all worsened(P﹤0. 05 or ﹤0. 01). Body mass index(BMI)decreased,arterial blood gas analysis,BNP, echocardiography and PSG of NPPV group after treatment all improved significantly( P ﹤ 0 . 01 ). Compared with control group after treatment,NPPV group improved significantly in BMI,arterial blood gas analysis,BNP,echocardiography and PSG( P ﹤0. 01 ). Conclusion NPPV is an effective method for patients with obesity hypoventilation syndrome complicated by heart failure.

Key words: obesity hypoventilation syndrome, heart failure, continuous positive airway pressure